View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Oct. 10 (HealthDay News) -- Cannabis extract (CE) is effective at treating muscle stiffness in patients with multiple sclerosis (MS), according to a study published online July 12 in the Journal of Neurology, Neurosurgery & Psychiatry.
John Peter Zajicek, Ph.D., from the University of Plymouth in the United Kingdom, and colleagues randomized patients with stable MS to receive oral CE (144 patients) or placebo (135 patients). This phase III trial consisted of a screening period; a two-week dose titration phase, from 5 mg daily to a maximum of 25 mg of tetrahydrocannabinol; and a 10-week maintenance phase.
The researchers found that, after 12 weeks, the rate of relief from muscle stiffness was almost twice as high with CE than with placebo (29.4 versus 15.7 percent; odds ratio, 2.26). After four and eight weeks, the results were similar for muscle stiffness and also for all further category rating scales of body pain, spasms, and sleep quality.
"Our findings suggest that standardized CE can be clinically useful in treating the highly complex phenomenon of spasticity in MS," the authors write. "Effective pain relief is also achieved by CE, especially in patients with a high baseline pain score."
The study was partially funded by Weleda. Two authors disclosed financial ties to the pharmaceutical industry; one author is a named inventor on two patents regarding cannabinoid use in MS.
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top