Shelf Life of Blood Appears Shorter Than Thought

Decreased membrane deformability not readily reversible after transfusion, small study finds

FRIDAY, March 8 (HealthDay News) -- Red blood cells stored longer than three weeks begin to lose their flexibility, according to a small study published online Feb. 28 in Anesthesia & Analgesia.

Steven M. Frank, M.D., from Johns Hopkins University in Baltimore, and colleagues examined erythrocyte deformability in 16 posterior spinal fusion surgery patients, comparing those who required moderate transfusion (greater than or equal to five units erythrocytes) and those who received minimal transfusion (zero to four units erythrocytes). Samples were drawn directly from the blood storage bags before transfusion and from patients before and after transfusion (over three postoperative days). The elongation index measured using ektacytometry quantitatively assessed deformity.

The researchers found that erythrocyte deformability was significantly decreased compared to preoperative baseline in patients receiving moderate transfusion, but not after minimal transfusion. Over three postoperative days, these changes remained consistent. In erythrocytes stored for 21 days or less, deformability was significantly less than in those stored for more than 21 days or those drawn from patients preoperatively. Intermediate deformability was seen in cell-salvaged erythrocytes, which was greater than that of erythrocytes stored 21 days or more but less than that of erythrocytes stored less than 21 days.

"The findings demonstrate that increased duration of erythrocyte storage is associated with decreased cell membrane deformability and that these changes are not readily reversible after transfusion," the authors write.

One author disclosed financial ties to Terumo BCT and Fenwal Labs, both involved with blood storage.

Abstract
Full Text (subscription or payment may be required)

Health News Copyright © 2013 HealthDay. All rights reserved.

Powered by

jQuery UI Accordion - Default functionality

For life-long learning and continuing professional development, come to Lippincott's NursingCenter.

Nursing Jobs Plus
Featured Jobs
Recommended CE Articles

Debunking Three Rape Myths
Journal of Forensic Nursing, October/December 2014
Expires: 12/31/2016 CE:2.5 $24.95


Drug updates and approvals: 2014 in review
The Nurse Practitioner, 13December 2014
Expires: 12/31/2016 CE:3 $27.95


Can Food Processing Enhance Cancer Protection?
Nutrition Today, September/October 2014
Expires: 10/31/2016 CE:2 $21.95


More CE Articles

Subscribe to Recommended CE

Recommended Nursing Articles Evidence Based Practice Skin Care Network NursingCenter Quick Links What’s Trending Events