View Entire Collection
By Clinical Topic
By State Requirement
Diabetes – Summer 2012
Future of Nursing Initiative
Heart Failure - Fall 2011
Influenza - Winter 2011
Nursing Ethics - Fall 2011
Trauma - Fall 2010
Traumatic Brain Injury - Fall 2010
Fluids & Electrolytes
WEDNESDAY, Oct. 16 (HealthDay News) -- Arterial stiffness correlates with β-amyloid (Aβ) deposition in the brain of dementia-free older adults, according to a study published online Oct. 16 in Neurology.
Timothy M. Hughes, Ph.D., from the University of Pittsburgh, and colleagues studied a cohort of 91 dementia-free participants aged 83 to 96 years, who completed brain magnetic resonance imaging and positron emission tomography (PET) imaging using Pittsburg compound B in 2009. Resting blood pressure (BP), mean arterial pressure (MAP), and arterial stiffness by pulse wave velocity (PWV) were measured in the central, peripheral, and mixed (brachial ankle PWV [baPWV]) vascular beds in 2011.
The researchers found that 44 participants were Aβ-positive on PET scan. There was an association between Aβ deposition and mixed PWV, systolic BP, and MAP. An increase in baPWV (one standard deviation) resulted in a two-fold increase in the likelihood of being Aβ-positive (P = 0.007). High white matter hyperintensity (WMH) burden correlated with elevated central PWV, systolic BP, and MAP. Each standard deviation increase in PWV correlated with a two- to four-fold increase in the odds of being Aβ-positive and having high WMH, compared to Aβ-negative individuals with low WMH burden.
"Arterial stiffness was highest in individuals with both high Aβdeposition and WMH, which has been suggested to be a 'double hit' contributing to the development of symptomatic dementia," the authors write.
Two authors are coinventors of the Pittsburg compound B technology used in this study. Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.
Full Text (subscription or payment may be required)
Sign up for our free enewsletters to stay up-to-date in your area of practice - or take a look at an archive of prior issues
Join our CESaver program to earn up to 100 contact hours for only $34.95
Explore a world of online resources
Back to Top