Aspirin Post Hip Replacement OK for Extended Prophylaxis
Aspirin for 28 days non-inferior and as safe as dalteparin for preventing venous thromboembolism
Wednesday, June 05, 2013

Few Physicians Meeting Meaningful Use in Early 2012
Managing patient populations with electronic systems not easy for many physicians
Wednesday, June 05, 2013

Twitter Analysis Can Inform Vaccination Campaigns
Most medical information shared on Twitter is from substantiated, professional sources
Wednesday, June 05, 2013

CDC: Small Drop in Those With Difficulty Paying Medical Bills
Decrease in adults (<65 years) and children in families with difficulty paying medical bills
Tuesday, June 04, 2013

Increasing Drug Rx Linked to Exposure, Poisoning in Children
Strongest link seen for opioids; greatest risk across all medications seen for 0- to 5-year-olds
Monday, June 03, 2013

Religious Vaccine Exemptions Increasing in New York State
Second study supports immunization at sick visits rather than waiting for well-baby visits
Monday, June 03, 2013

Health of Nation Reviewed With Focus on Emergency Care
Twenty percent of people reported visiting emergency department at least once in last year
Monday, June 03, 2013

New Meds, Medical Devices Up Heart Failure Outcomes
Findings in patients with advanced heart failure referred to a tertiary university medical center
Friday, May 31, 2013

Standard VTE Prevention Supported for Bariatric Surgery
Review looks at both intravascular filters and augmented pharmacologic dosing strategies
Friday, May 31, 2013

With Legalization, Marijuana Poisoning Up in Youth
Findings based on children who sought care before, after Colorado legalized medical marijuana
Friday, May 31, 2013

New Statement Released by Anticoagulation Forum
Consensus statement to help organizations develop better systems to cut medication errors
Friday, May 31, 2013

No Effect of Attention Deficit Drugs on Substance Abuse
Childhood treatment with psychostimulants does not increase or decrease risk
Friday, May 31, 2013

Exserohilum rostratum Can Relapse After Antifungal Tx
80-year-old man relapses after antifungal therapy, resolution of symptoms and CSF white-cell count
Friday, May 31, 2013

Double-Dose Oseltamivir Not Beneficial in Severe Influenza
No virological or clinical advantage compared with standard-dose treatment for children, adults
Friday, May 31, 2013

Meta-Analysis Compares Vascular Risks for NSAIDs
Diclofenac and possibly ibuprofen linked to increased vascular risk; less risk for naproxen
Thursday, May 30, 2013

One-Third of Medical Students Have Implicit Anti-Fat Bias
Most are unaware of their significant implicit bias, although it could affect quality of care
Thursday, May 30, 2013

For Women, Calcium Intake Tied to Reduced Mortality Risk
Link not modified by vitamin D intake; no link observed with vitamin D or calcium intake in men
Thursday, May 30, 2013

Antiviral Resistance Identified in Novel Flu A/H7N9
In case series of 14 patients, two identified with Arg292 Lys mutation in virus neuraminidase gene
Thursday, May 30, 2013

Majority of Clinicians Support Medicinal Marijuana Use
Based on votes and responses to interactive feature, 76 percent support use of marijuana
Thursday, May 30, 2013

Billions Can Be Saved With Pharmacy Benefit Management
Strategies include use of generic drugs, affordable brands, negotiation of pharmacy dispensing fee
Wednesday, May 29, 2013

Vaccine for Enterovirus-71 Effective Against Disease
Ninety percent efficacy against hand, foot, mouth disease; 80.4 percent against EV71-linked disease
Wednesday, May 29, 2013

Transparency Key to Improving Value Care for Patients
Data on price, utilization, and quality should be made publicly available to ensure greater value
Wednesday, May 29, 2013

ASC: Rapid BP Lowering Tx No Better for Intracerebral Bleed
No significant reduction in death, severe disability with intensive versus guideline-recommended tx
Wednesday, May 29, 2013

AAN Releases Periprocedural Anticoagulant Care Guideline
Risk of bleeding from antithrombotic medications varies according to medical procedure
Tuesday, May 28, 2013

HHS: End-of-2013 Targets for EHR Use Already Reached
>50 percent of doctor offices, 80 percent of eligible hospitals using electronic health records
Tuesday, May 28, 2013

ACOG Endorses CDC Vaccine Recommendations in Pregnancy
Given newborn's vulnerability to pertussis, Tdap vaccine recommended during each pregnancy
Tuesday, May 28, 2013

FDA Approves A1c Test for Diabetes Diagnosis
Test is first of its kind to receive clearance for this purpose
Tuesday, May 28, 2013

ESC: Coenxyme Q10 Beneficial for Heart Failure
Patients receiving supplementation have reduced heart failure hospitalization, cardiovascular death
Tuesday, May 28, 2013

Not All Parents Think They Can Influence Teen Drug Use
More than 90 percent of parents of 12- to 17-year-olds report discussing substance use in past year
Tuesday, May 28, 2013

Docs Anticipating Changes Ahead As ACA Progresses
Most expect ACA to continue as planned; expect further integration for themselves, hospitals
Monday, May 27, 2013

Pain Conditions Linked to Increased Risk of Suicide
Back, migraine, and psychogenic pain increases risk of suicide in patients using VHA services
Monday, May 27, 2013

Depression Linked to Severe Hypoglycemia in Diabetes
Shorter time to first episode, higher number of severe episodes in depressed versus non-depressed
Friday, May 24, 2013

Glaucoma Drugs Linked to Eyelid Drooping
Prostaglandin analogues associated with problems that can interfere with vision
Friday, May 24, 2013

No Benefit of Intensive Insulin Rx in Hyperglycemia in Hospitalized
Guidelines from the American College of Physicians note that insulin may cause harm
Friday, May 24, 2013

Glucosamine Supplementation Linked to Intraocular Pressure
Reversible effect seen, with drop in intraocular pressure after discontinuation of supplementation
Friday, May 24, 2013

About One in Four Uninsured Could Be Excluded From ACA
Twenty-seven percent of those eligible for assistance tax credits do not have checking account
Friday, May 24, 2013

Data Support Basing Health Decisions on Both Benefit, Cost
Health care cost varies from $2 to $224 per month of health status-adjusted life expectancy
Friday, May 24, 2013

Frequent Heartburn Linked to Cancer of Pharynx and Larynx
Antacid use may lower risk
Thursday, May 23, 2013

Studies Discuss Complications of Type 2 Diabetes in Youth
Series of studies, editorials discuss complications, including retinopathy, cardiovascular disease
Thursday, May 23, 2013

ACOG: Hormone Therapy Not Recommended to Prevent CHD
For menopausal women, heart-healthy lifestyles and other strategies recommended to reduce risk
Thursday, May 23, 2013

Long-Acting Bronchodilators Up Cardiovascular Risk in COPD
Findings among older adults newly prescribed long-acting β-agonists or anticholinergics
Thursday, May 23, 2013

Parents Unaware of Scope of Teens' Use of 'Study Drugs'
One in 100 parents believe their teens use study drugs, while one in eight 12th graders report use
Thursday, May 23, 2013

Stimulant Normalizes Brain Activation in Youth With ADHD
Methylphenidate ups brain activation in children with attention-deficit/hyperactivity disorder
Wednesday, May 22, 2013

ATS: Azithromycin Delays Next Hospitalization in COPD
Significant prolongation of time to next respiratory hospitalization with antibiotics
Wednesday, May 22, 2013

Fecal Microbiota Tx Feasible for Recurrent C. difficile in HIV
Observation from two patients shows no further recurrence of C. difficile after fecal transplant
Wednesday, May 22, 2013

Systematic Screening of Med Adherence Will ID Barriers
Tailored interventions will be feasible following systematic monitoring of adherence
Wednesday, May 22, 2013

SSRI Reduces Stress-Induced Myocardial Ischemia
Escitalopram reduces mental stress-induced ischemia in at-risk patients
Tuesday, May 21, 2013

ATS: Short Steroid Course Non-Inferior for COPD Exacerbations
Five-day systemic glucocorticoid tx non-inferior to 14-day tx for reexacerbations within 180 days
Tuesday, May 21, 2013

Oxandrolone Not Effective for Pressure Ulcer Treatment
For veterans with spinal cord injury no benefit over placebo for healing or ulcers remaining closed
Tuesday, May 21, 2013

Study Examines Outbreak of Spinal Infections in Michigan
Increased case finding may partially explain more cases found in Michigan
Tuesday, May 21, 2013

USPSTF: Primary Care Docs Can Promote Dental Health
Grade B recommendation for use of oral fluoride supplementation, fluoride varnish for under-5s
Tuesday, May 21, 2013

DDW: Vitamin D May Be Beneficial in Crohn's Disease
Improvements in muscle strength, fatigue, quality of life for patients with stable Crohn's
Monday, May 20, 2013

Digital Divide Exists With Physician EHR Adoption
Adopters found to be optimistic about IT's potential, while non-adopters remain skeptical
Monday, May 20, 2013

Whole-Cell Pertussis Vaccines More Effective Protection
Teens who received DTaP have significantly higher risk of developing pertussis during outbreak
Monday, May 20, 2013

Marijuana Use Tied to Lower Fasting Insulin Level, HOMA-IR
Current users have lower fasting insulin, lower insulin resistance, smaller waist circumference
Friday, May 17, 2013

Prednisolone Disturbs Carbohydrate Metabolism
Patients with inflammatory diseases should consider other anti-inflammatory agents
Friday, May 17, 2013

ASH: Practicing Yoga May Help Lower Blood Pressure
Yoga two to three times a week on average lowers both systolic and diastolic BP by three points
Thursday, May 16, 2013

Meds for Back Pain Tied to Higher Erectile Dysfunction Risk
Dose and duration of opioid use associated with increased odds of erectile dysfunction
Wednesday, May 15, 2013

Primrose Oil, Borage Oil Not Effective Eczema Treatment
Findings based on extensive literature review over several decades of research
Wednesday, May 15, 2013

Combination Osteoporosis Rx Further Improves Bone Density
Teriparatide and denosumab administered together more effective than either therapy alone
Wednesday, May 15, 2013

Hospital Hypoglycemia Rates Up in Black Men With Diabetes
Home diabetes regimen partially explains the increased risk of hypoglycemia
Tuesday, May 14, 2013

Review: In-Hospital Antibiotic Rx Behavior Can Be Improved
Meta-analyses show that restrictive and persuasive methods improve prescribing in hospital setting
Tuesday, May 14, 2013

FDA Approves Breo Ellipta for Treatment of COPD
Respiratory disease is the third-leading cause of death in the United States
Monday, May 13, 2013

New FDA Survey to Assess Doc Attitudes on DTC Advertising
New survey will examine attitudes among non-physicians, including nurses, physician assistants
Monday, May 13, 2013

Specific Antibiograms Needed for Outpatients in Primary Care
Differences in susceptibility to ciprofloxacin among P. aeruginosa for inpatients, primary care
Friday, May 10, 2013

User Satisfaction With Electronic Health Records Down
Twelve percent decrease in user satisfaction since 2010; increase in very dissatisfied users
Friday, May 10, 2013

Poor Service, Bedside Manner Top Patients' Online Complaints
Review of 'rate-your-doctor' websites reveals patients' most common gripes
Friday, May 10, 2013

Antidepressants Benefit Post-CABG Mental Health Recovery
Escitalopram doesn't affect mortality, morbidity, but improves depression, mental health
Thursday, May 09, 2013

HRS: No Need to Stop Warfarin for Pacemaker, ICD Surgery
Fewer significant pocket-device hematomas for continued warfarin versus bridging heparin
Thursday, May 09, 2013

Smartphones, Smartphone Apps Increasingly Used by Docs
Two reports show use of smartphones and apps for professional purposes is increasing
Thursday, May 09, 2013

HHS Releases Data on Inpatient Charges for Hospital Services
HHS is also providing funding to data centers to collate, analyze, publish data to assist consumers
Thursday, May 09, 2013

n-3 Fatty Acids No Benefit for High-Risk Cardio Patients
No drop in cardiovascular mortality or morbidity for patients without myocardial infarction
Wednesday, May 08, 2013

ARVO: Additional Nutrients Do Not Reduce Progression to AMD
Adding carotenoids, omega-3s does not further lower risk of age-related macular degeneration
Wednesday, May 08, 2013

Application for Health Coverage Has Been Simplified, Shortened
First-time consumers will be able to complete one three-page application, see all available options
Wednesday, May 08, 2013

Guidelines Issued for Exercise-Induced Bronchoconstriction
Evidence-based guidelines developed for diagnosis and appropriate management of EIB
Wednesday, May 08, 2013

Ambrisentan Not Effective in Idiopathic Pulmonary Fibrosis
Increased risk of disease progression, respiratory hospitalizations with ambrisentan treatment
Tuesday, May 07, 2013

AUA: Many Men With Erectile Dysfunction Untreated
Under-treatment persists despite heavy promotion in the media
Monday, May 06, 2013

AUA: Low-Dose Pill Linked to Chronic Pelvic Pain Symptoms
Low-dose OCP users also have increased incidence of pain or discomfort during or after climax
Monday, May 06, 2013

PAS: Children With Strep Don't Need to Toss Toothbrushes
Toothbrushes from children with GAS did not show GAS bacterial growth
Monday, May 06, 2013

AAP Endorses Pediatric Acne Management Guidelines
Evidence-based treatment recommendations provide guidance for childhood, adolescent acne
Monday, May 06, 2013

Medicaid Coverage Doesn't Lead to Better Physical Health
After two years, no reductions noted in measured BP, cholesterol, or glycated hemoglobin levels
Thursday, May 02, 2013

Nearly One-Third Don't Pick Up New Osteoporosis Rx
Women receiving Rx from rheumatology, internist practicing 10 or more years more likely to get meds
Thursday, May 02, 2013

Health Industry Payment Details to Be Publicly Available
New CMS website will detail financial ties between drug, device manufacturers and docs, hospitals
Thursday, May 02, 2013

Penicillin Prophylaxis Prevents Recurrent Leg Cellulitis
Protective effect disappears after stopping treatment
Wednesday, May 01, 2013

Azithromycin Not Tied to Increased Risk of CV Death
Versus no antibiotics, penicillin; based on a general population of young, middle-aged adults
Wednesday, May 01, 2013

SAMHSA: Sharp Rise in ER Visits Due to Zolpidem
Emergency department visits up over 200 percent from 2005 to 2010
Wednesday, May 01, 2013

Plan B Approved for Women 15 Years and Older Without Rx
FDA says company submitted data showing that women 15 years and older understood proper use
Wednesday, May 01, 2013

Breath Test Can Detect Illicit Drug Use Up to 24 Hours Later
Simple, commercially available breath sampler can detect 12 analytes
Wednesday, May 01, 2013

FDA Approves Kcentra to Reverse Anticoagulation
Can be administered faster than plasma to stop severe bleeding in heart patients
Tuesday, April 30, 2013

Novel System Proposed for Accountable Cancer Care
Cancer Care Groups proposed, which would be compensated under bundled payment system
Tuesday, April 30, 2013

Comprehensive Analysis Supports SERMs for Cutting Breast Cancer
Meta-analysis shows reduced incidence of breast cancer, especially in first five years of follow-up
Tuesday, April 30, 2013

Renewed Efforts From AAFP to Repeal OTC Provision in ACA
Provision will increase costs to health care system; add to burden on physician offices
Tuesday, April 30, 2013

Non-Inferior Response With Two-Dose HPV Vaccine
Non-inferior antibody response one month after last dose for girls receiving two or three doses
Tuesday, April 30, 2013

Multicenter Study Links Peri-Op SSRI Use to Adverse Outcomes
Increased odds of in-hospital mortality, bleeding, 30-day readmission, after adjustment
Tuesday, April 30, 2013

FDA Concerned Caffeinated Foods Could Harm Children
Such products becoming abundant in U.S. markets
Tuesday, April 30, 2013

High Doses of Saw Palmetto Appear Safe Over 18 Months
No evidence of toxicity for patients given doses of up to 960 mg daily for up to 18 months
Monday, April 29, 2013

Rx for High-Risk Meds Varies Widely in Medicare Advantage
Women, whites, low-income patients, and those in the South more likely to receive high-risk meds
Monday, April 29, 2013

Med Errors Common Among Pediatric Cancer Outpatients
Rate of 3.6 medication errors with injury per 100 patients; errors more common with non-chemo meds
Monday, April 29, 2013

Zoledronic Acid Linked to Early Increase in Sclerostin Levels
For postmenopausal women, sclerostin up within two days; returns near to baseline after 360 days
Monday, April 29, 2013

FDA Announces New Network to Focus Exclusively on Patients
Interactive tool designed to educate patients and advocates about processes of drug development
Monday, April 29, 2013

FDA: Purveyors of Phony Botox Targeting U.S. Practices
Products advertised through fax; not FDA approved
Monday, April 29, 2013

Medical Interns Spending Less Time With Patients
More time being spent at a computer since work hours were limited in 2011
Friday, April 26, 2013

Report Updates Impact of Hypoglycemia in Diabetes
Reviews outcomes, strategies, and current gaps in knowledge
Friday, April 26, 2013

Saturday Marks Sixth Annual Rx Drug Take-Back Day
Collection sites will be available around the country
Friday, April 26, 2013

Review: All Approved Drugs Similarly Prevent Migraines
Off-label angiotensin-inhibiting drugs and beta-blockers have favorable benefit-to-harm ratios
Thursday, April 25, 2013

One 12-Ounce Sweet Drink a Day Ups Risk of T2DM 22 Percent
Association for sweet drinks persists, even after adjustment for energy intake, body mass index
Thursday, April 25, 2013

Prevalence, Costs of Heart Failure Estimated for 2030
More than eight million U.S. adults expected to have heart failure by 2030; $70 billion in costs
Thursday, April 25, 2013

Physicians Less Empathetic in Talking to Heavy Patients
Patient weight plays no role in quantity of physicians' biomedical communications
Thursday, April 25, 2013

Analgesics in Endurance Events Can Have Serious Adverse Effects
GI, kidney, and cardiovascular adverse events may increase with analgesic dose
Thursday, April 25, 2013

Diabetes Target Achievement Up From 1999 to 2010, More Needed
Only 14.3 percent meet targets for glycemic control, BP, LDL cholesterol, and tobacco use
Wednesday, April 24, 2013

Diagnostic Errors Are the Leading Type of Malpractice Claim
Diagnosis-related payments from 1986 to 2010 totaled $38.8 billion
Wednesday, April 24, 2013

Maternal Use of Valproate Ups Risk of Autism in Offspring
Significantly increased risk of autism spectrum disorder, childhood autism with prenatal exposure
Tuesday, April 23, 2013

Peri-Noncardiac Op Exposure to β-Blockers Improves Outcome
Exposure tied to lower mortality for patients with two or more Revised Cardiac Risk Index factors
Tuesday, April 23, 2013

>40 Percent of Parents Give Cough Meds to Young Children
Despite warning label that products should not be used for young children, many parents give meds
Tuesday, April 23, 2013

Severe Cutaneous Adverse Rxns Up in Allopurinol Initiators
SCARs are rare; usually occur within first 180 days of initiating treatment
Tuesday, April 23, 2013

Drop in Genital Warts in Young Women Since HPV Vaccination
Five years into vaccination program, proportion of young women ≤30 years with genital warts down
Tuesday, April 23, 2013

Breast Density Linked to Breast Cancer-Specific Survival
For women treated with tamoxifen, decrease in mammographic density tied to improved survival
Tuesday, April 23, 2013

Parental Permissiveness Linked to Rx Drug Abuse, Misuse
About one-quarter of teens report abuse, misuse of prescription meds; about half use pot, alcohol
Tuesday, April 23, 2013

TEDMED: Patients Can Become Leaders on the Health Team
Communities can raise their own leaders; may be key approach to change at community level
Monday, April 22, 2013

TEDMED: Get the Joy Back Into Health and Wellness
Surgeon General talks about importance of bringing joy back into movement and medicine
Monday, April 22, 2013

TEDMED: Is the Obesity Crisis a Disguise for a Deeper Problem?
Surgeon-researcher discusses hypothesis that we may be 'blaming the victims'
Monday, April 22, 2013

Pot Smoking Linked to Some Metabolic Changes
Increase in visceral adiposity and adipose tissue insulin resistance
Friday, April 19, 2013

Patient-Centered Decision Making Ups Health Outcomes
Health care outcomes improved for 71 percent of contextual factors that were addressed by PCDM
Friday, April 19, 2013

FDA Approves Updated Label for Reformulated OxyContin
Reformulated OxyContin has physical, chemical properties that should cut potential for abuse
Friday, April 19, 2013

Family-Centered Teaching Rounds Good for Patients, Students
Higher patient satisfaction with exam room presentations; many residents have concerns
Thursday, April 18, 2013

Relative Proportion of MRSA Increasing in S. aureus Isolates
Methicillin-sensitive S. aureus becoming more resistant to antibiotics
Thursday, April 18, 2013

Community Benefit Spending Varies for Tax-Exempt Hospitals
Most spent on charity care, patient services; less spent on community health improvement
Wednesday, April 17, 2013

Glutamine, Antioxidants No Benefit to Critically Ill Patients
Glutamine linked to increase in 28-day mortality among critically ill adults with multiorgan failure
Wednesday, April 17, 2013

Endocrine Therapy Often Incomplete after Breast Cancer
Study examines factors associated with initiation and persistence of treatment
Tuesday, April 16, 2013

Risk of New-Onset Diabetes Varies With Different Statins
Lowest risk for pravastatin 40 mg/day; higher risk for rosuvastatin 20mg/day versus placebo
Monday, April 15, 2013

Quality Improvement Methods Up Appropriate Antibiotic Rx
Study focuses on children aged 3 months or older with community-acquired pneumonia
Monday, April 15, 2013

FDA Warns Consumers of Dangers of the Stimulant DMAA
Attempt to halt marketing of dietary supplements with DMAA after reports of illness, death
Monday, April 15, 2013

Cardiac Function Unaffected by Prior Intensive Insulin Therapy
Prior glycemic exposure and not prior intensive insulin therapy impacts cardiac parameters
Friday, April 12, 2013

Drug-Facilitated Weight Loss Benefits Cardiometabolic Status
Weight loss, including phentermine/topiramate-induced, linked to reductions in lipids, blood pressure
Friday, April 12, 2013

Topical Treatment Effective for Toenail Fungal Infection
Mycologic cure rate significantly higher with 48 weeks of efinaconazole versus placebo
Friday, April 12, 2013

Topical Anesthetics Effective for Premature Ejaculation
Significant improvements seen for ejaculatory control, sexual satisfaction, and distress
Friday, April 12, 2013

Speech Details Practices to Improve U.S. Health Systems
Mayo Clinic CEO outlines key steps to create high-quality, low-cost care in America
Thursday, April 11, 2013

Fish Oil Has No Effect on Depression in Pregnancy
Does not prevent depression during pregnancy or post-partum for at-risk women
Thursday, April 11, 2013

Sales Representatives Provide Inadequate Safety Information
Physicians ready to prescribe with lack of data on harmful effects of promoted medicines
Thursday, April 11, 2013

Variation Seen in U.S. Antibiotic Prescription Rates
Higher rates of prescriptions for children, older patients, as well as those in the South
Wednesday, April 10, 2013

Patients Using Different Rx Strategies to Save Money
Cost-saving strategies differ by age, health insurance status, and poverty status
Tuesday, April 09, 2013

Diclegis Approved for Nausea/Vomiting in Pregnancy
Doxylamine succinate and pyridoxine hydrochloride approved to treat pregnant women experiencing nausea and vomiting
Tuesday, April 09, 2013

AAN Issues Guidelines for Tapeworm Ix on Rise in U.S.
Study finds albendazole plus dexamethasone, prednisolone most effective
Tuesday, April 09, 2013

NYC Health Department, ER Docs Clash Over Opioid Guidelines
Some believe the recommendations unfairly target N.Y.C. emergency physicians
Tuesday, April 09, 2013

Amiodarone Treatment Is Linked to Higher Cancer Risk
Medication for arrhythmias may pose peril, especially in males with increasing dose
Monday, April 08, 2013

Majority of Americans Now Favor Legalizing Marijuana
Support for legalization increases across all ages, including younger and older adults
Monday, April 08, 2013

Growth Hormone Ups Height in Pediatric Dialysis Patients
Bone formation rates are higher with growth hormone, regardless of bone histologic features
Friday, April 05, 2013

Federal Judge Rules FDA Must Lift Restrictions on Plan B
U.S. must make 'morning-after' pill available over-the-counter for all without prescription
Friday, April 05, 2013

Statins Show Protective Effect Against Acute Kidney Injury
Initiating use prior to coronary artery bypass grafting surgery may modestly reduce risks
Friday, April 05, 2013

Prevalence of Self-Reported Hypertension Rises in U.S.
Increase is small, but significant, and proportion of adults taking medication is up as well
Thursday, April 04, 2013

Glucocorticoids Are Tied to Increased Risk of Clots
Higher rates of venous thromboembolism seen in both present and recent medication users
Thursday, April 04, 2013

CMS Announces Final Rates for Medicare Drug, Health Plans
Program updates for 2014 designed to lower beneficiary costs, increase value
Thursday, April 04, 2013

Patients Taken Off Statins Can Be Re-Challenged With Success
Study finds halting therapy could lead to many preventable cardiovascular events
Tuesday, April 02, 2013

FDA Allows Change to Nicotine Replacement Therapy Labels
Changes will include removal of warning not to use tx if smoking, chewing tobacco, using snuff
Tuesday, April 02, 2013

New Drug Approved for Type 2 Diabetes
Invokana blocks reabsorption of glucose by the kidneys
Monday, April 01, 2013

Many Uninsured Vets Will Be Eligible for Medicaid Under ACA
But most of uninsured will have new coverage options only if their state expands Medicaid
Friday, March 29, 2013

Using Internet Search Logs Can Help Identify Drug Interactions
Tool may alert authorities to potential problems and aid in surveillance of adverse events
Thursday, March 28, 2013

Study: Primary Care Extension Program Should Be Funded
Authors say PCEP important to improving public health, translating research into practice
Thursday, March 28, 2013

Certified Primary Stroke Centers Use More Rt-PA
Findings in nationwide comparison of patients with ischemic stroke
Tuesday, March 26, 2013

FDA Approves Inhaler for Cystic Fibrosis Patients
Antibiotic device treats Pseudomonas aeruginosa lung infections
Monday, March 25, 2013

Telehealth in Addition to Usual Care Not Cost-Effective
For adults with long-term health conditions, no increase in quality adjusted life years
Friday, March 22, 2013

Impact of Budget Sequestration on Health Care Discussed
Cuts will not be equal: Medicaid protected; 2 percent cut for Medicare; 8.2 percent cut for NIH
Thursday, March 21, 2013

Effect of Immigration Status on Medicaid Eligibility Discussed
Seventeen percent of low-income, uninsured nonelderly are unauthorized or recently legal
Wednesday, March 20, 2013

Manual Osteopathic Treatment Improves Chronic Back Pain
Patients report pain relief, but not improvements in back functioning or work disability
Wednesday, March 20, 2013

Chlorthalidone No Better Than Hydrochlorothiazide for HTN
Increased risk of hypokalemia seen with chlorthalidone among older adults
Wednesday, March 20, 2013

Aristolochic Acid Nephropathy, a Global Health Problem
Review of widely used Chinese herbs identifies need for regulation and further study
Tuesday, March 19, 2013

Conflict-of-Interest Disclosures Common at 2011 AAOS Meeting
All featured symposia at the American Academy of Orthopaedic Surgeons disclosed conflicts
Tuesday, March 19, 2013

Pharmacist-Led Home BP Program Shows Success
Patients report reduced readings, better control, and improved care for hypertension
Monday, March 18, 2013

Black Children Less Likely to Be Prescribed Antibiotics
Also less likely to be diagnosed with conditions requiring antibiotics, even from the same doctor
Monday, March 18, 2013

Final Rule in Notice of Benefit, Payment Parameters Issued
Rule expands on existing standards for risk adjustment, reinsurance, risk corridors
Friday, March 15, 2013

Pharmaceutical Companies Are Reducing Promotional Spending
Much less spent to promote biologics compared with small molecule drugs, study finds
Friday, March 15, 2013

Cardio Risks Need Evaluation Before Prescribing Statins
Study examines doctors' approach in relationship to baseline heart disease risks
Friday, March 15, 2013

Health Insurance Exchanges Will Mainly Be Run by Feds
Federal government will establish exchanges for 26 states; state-run exchanges for 17 states, D.C.
Friday, March 15, 2013

Rules Must Evolve to Allow New Drugs for Early Alzheimer's
Use of single scale combining cognition, function could allow drugs to be approved for early disease
Thursday, March 14, 2013

Stimulated Reporting Accounts for High Dabigatran Bleeding
Analysis of FDA Mini-Sentinel database shows bleeding rates no higher than for warfarin
Thursday, March 14, 2013

Vitamin D3 Supplementation Lowers Systolic BP in Blacks
Oral regimen for three months found to be effective, but no result seen on diastolic readings
Thursday, March 14, 2013

FDA Reaffirms Azithromycin Tie to Heart Rhythm Abnormalities
Drug label has been updated to strengthen Warnings and Precautions section
Wednesday, March 13, 2013

AAN: Add-On Drug Improves Memory in Alzheimer's Disease
Researchers find positive effect from first human trials of a selective adrenoceptor antagonist
Wednesday, March 13, 2013

2009 H1N1 Vaccine Tied to Small Risk of Guillain-Barré Syndrome
Small but significant increase in risk with influenza (H1N1) 2009 monovalent inactivated vaccine
Wednesday, March 13, 2013

$120 Million to Be Sequestered From Health Centers in 2013
Losses likely to be more severe for health centers that are especially grant dependent
Tuesday, March 12, 2013

Worldwide, Contraceptive Prevalence Up Since 1990
Absolute number of women with demand for contraception likely to increase by 2015
Tuesday, March 12, 2013

ACC: High-Dose Vitamins Don't Cut Recurrent Cardiac Events
But high-dose vitamins plus active chelation may reduce events among patients with previous MI
Tuesday, March 12, 2013

ACC: Digoxin Cuts 30-Day Admission for Heart Failure
Drug shows no significant effect on mortality for seniors with reduced ejection fraction
Tuesday, March 12, 2013

Aspirin Cuts Melanoma Risk in Postmenopausal Caucasians
Dose-response association seen, with longer duration of use linked to greater reduction in risk
Monday, March 11, 2013

ACC: Cangrelor Reduces Ischemic Events in Primary PCI
And, prehospital fibrinolysis with timely angiography effective for reperfusion in STEMI
Monday, March 11, 2013

More Evidence of Waning Immunity of Pertussis Vaccine
Increasing risk of developing the illness in the six years after the last dose
Monday, March 11, 2013

FDA Encourages Opioid Prescribers to Pursue Training
Continuing medical education provided by opioid manufacturers set to combat misuse and abuse
Monday, March 11, 2013

ACC: Darbepoetin Alfa Doesn't Up Outcome in Heart Failure
For patients with mild-to-moderate anemia, treatment ups risk of thromboembolic events
Monday, March 11, 2013

Neonatal Size Unaffected by Gestational Diabetes Drugs
Changes in metabolic markers similar with metformin and insulin treatment
Friday, March 08, 2013

Opioid Guidelines for ER Docs Help, But More Study Needed
Efforts called important first steps toward addressing public health problem of abuse
Friday, March 08, 2013

Sleep Meds Up Hip Fracture Risk Among Nursing Home Residents
New users with mild cognitive impairment and those needing limited aid are most affected
Thursday, March 07, 2013

Cochrane Group Skeptical About Latest Roche Pledges
Roche has pledged to release full clinical study reports for Tamiflu, but conditions may apply
Thursday, March 07, 2013

Two Drug Classes Found Effective for Restless Legs Syndrome
Dopamine agonists, calcium channel alpha-2-delta ligands reduce symptoms
Wednesday, March 06, 2013

Clinical Trials Published Almost Two Years After Completion
Funding source, number of participants, and journal impact factor all affect time to publication
Wednesday, March 06, 2013

Nonheme Iron Intake Linked to Reduced Risk of PMS
Risk of premenstrual syndrome may be increased with high intake of potassium
Wednesday, March 06, 2013

Most Docs Report Information Overload in EHR-Setting
Docs who report information overload more likely to have missed results leading to delayed care
Wednesday, March 06, 2013

U.K. Health Performance Worse Than Comparable Countries
Tobacco, high blood pressure, high BMI leading risk factors for disability-adjusted life-years
Tuesday, March 05, 2013

Panel Recommends 10 Patient Safety Strategies
Ten strategies strongly encouraged for adoption; a further 12 strategies encouraged
Monday, March 04, 2013

CMS Reports on Progress Toward Improved Health Care
Progress includes slowing of growth in health care spending, decrease in readmissions
Monday, March 04, 2013

Computerized Provider Order Entry System Cuts Rx Errors
Given effect size, CPOE use, estimated reduction of 12.5 percent in medication errors each year
Monday, March 04, 2013

Sequestration to Impact Health Care-Related Programs
Medicare providers and medical researchers brace for cuts from fiscal impasse
Friday, March 01, 2013

Glucagonlike Peptide 1-Based Tx Increases Pancreatitis Risk
Findings among adults with type 2 diabetes taking exenatide, sitagliptin phosphate
Thursday, February 28, 2013

Isotretinoin Not Linked to Increased Risk of IBD
Case-control study and meta-analysis show no increased risk of ulcerative colitis, Crohn's
Wednesday, February 27, 2013

Ondansetron Not Linked to Adverse Fetal Outcomes
Findings in large cohort of women exposed to ondansetron during both early and mid-pregnancy
Wednesday, February 27, 2013

Risk of Child Narcolepsy Up With Pandemrix Vaccination
Increased odds of ASO3 adjuvanted pandemic A/H1N1 2009 vaccination before narcolepsy onset
Wednesday, February 27, 2013

AAAAI: EpiPens Should Be Given in Lower Thigh in Heavy Kids
In very obese children, calf injections offer greater chance of intramuscular administration
Wednesday, February 27, 2013

FDA Approves Osphena for Dyspareunia Post-Menopause
Once-daily pill carries boxed warning regarding risk of unusual endometrial bleeding, stroke, DVT
Wednesday, February 27, 2013

FDA: Omontys Injection Pulled From Market
Voluntary recall of anemia drug due to reports of anaphylaxis, including three deaths
Tuesday, February 26, 2013

Novel Chemotherapies More Often Used On- Than Off-Label
Off-label use, accounting for 30 percent, conforms to NCCN-supported indications in ~half of cases
Monday, February 25, 2013

USPSTF: Vitamin D, Calcium Supplements Don't Prevent Fx
For postmenopausal community-dwelling women, low-dose daily supplements not recommended
Monday, February 25, 2013

AAP Updates Guidelines for Acute Otitis Media
Updated guideline provides more stringent criteria to make a diagnosis and prescribe antibiotics
Monday, February 25, 2013

AAAAI: Omalizumab Treatment Effective for Urticaria
Reduces itch severity in patients resistant to antihistamines
Monday, February 25, 2013

CDC: 2012-2013 Flu Vaccine Not As Effective in Elderly
Vaccination appears to reduce need for office visits; preventive effect lower in elderly
Friday, February 22, 2013

Mental Health and Substance Use Disorder Benefits Expanded
New rule from HHS outlines standards for essential health benefits
Friday, February 22, 2013

CMS Proposes Payment and Policy Updates for 2014
Suggested changes will increase value and protection for beneficiaries
Thursday, February 21, 2013

FDA: Codeine After Surgery Puts Children At Risk
Food and Drug Administration urging use of alternative pain reliever
Thursday, February 21, 2013

IV Hydroxyethyl Starch Not OK in Critically Ill Patients
Compared to other resuscitation solutions there is an increased risk of death, kidney injury
Thursday, February 21, 2013

Extended Dabigatran Effective for Venous Thromboembolism
Carries lower risk of major, clinically relevant bleeding than warfarin; higher risk than placebo
Thursday, February 21, 2013

Pros, Cons of Medical Marijuana for Metastatic Cancer Explored
Case vignette highlights issues relating to smoking marijuana when conventional treatment has failed
Wednesday, February 20, 2013

Faster Adoption of Electronic Health Records Needed
Penalties under 2009 law start in 2015
Wednesday, February 20, 2013

Opioids Involved in Most Medical Overdose Deaths
Frequently involve drugs prescribed for mental health conditions
Wednesday, February 20, 2013

Erlotinib + Celecoxib Effective in Head and Neck Cancer
Combination therapy may help prevent head and neck cancer in high-risk patients
Wednesday, February 20, 2013

Multimodality Approach Needed to Reengineer Health Care
Rethinking, redesign, and application of necessary tools suggested for health care value reform
Tuesday, February 19, 2013

CMS: Unnecessary Medicare Regulations to Be Reformed
Proposed rule aims to increase ability of health care professionals to improve patient care
Tuesday, February 19, 2013

Artificial Intelligence Can Improve Patient Care
Modeling shows that computers can improve medical decisions and outcomes at lower costs
Tuesday, February 19, 2013

Depression Affects Efficacy of Herpes Zoster Vaccine
Elderly patients with depression have diminished response to vaccine, but antidepressants help
Tuesday, February 19, 2013

ASCO: Anticoagulant Use Predicts Metastatic Prostate CA Survival
Findings among men on any anticoagulant therapy while receiving docetaxel chemotherapy
Tuesday, February 19, 2013

Racial Disparities Observed in Opioid Monitoring
Black patients more often receive urine drug tests, less likely to receive pain specialist referral
Monday, February 18, 2013

CDC: Cephalosporin-Resistant Gonorrhea Imminent in U.S.
Asia, Europe report treatment failures; cefixime minimum inhibitory concentration up in U.S.
Monday, February 18, 2013

Therapy-Related Leukemia Risk Varied From 1975 to 2008
Risk after chemotherapy varies depending on initial cancer and treatment practices
Monday, February 18, 2013

SMFM: 17P Doesn't Prevent Preterm Labor in Twin Births
May actually be harmful in women with a short cervix carrying twins
Friday, February 15, 2013

Health Care-Associated Infections Decreased in 2011
Largest drop in central line-associated bloodstream infections; surgical site infections also down
Friday, February 15, 2013

Post-STEMI, Beta Blockers Cut Long-Term Mortality for Some
Higher- but not lower-risk patients benefit from beta-blocker therapy after PCI for STEMI
Friday, February 15, 2013

Use of Emergency Contraception Has More Than Doubled
~11 percent of women have ever used emergency contraception; up from 4.2 percent in 2002
Thursday, February 14, 2013

IOM Urges International Action to Eradicate Fake Drugs
Falsified and substandard meds are ineffective; may trigger resistance and cause illness, death
Thursday, February 14, 2013

Psychological, Sexual Impact of Female Breadwinners Explored
Men who are outearned by their wives more likely to use erectile dysfunction medications
Thursday, February 14, 2013

Oregon Experiment Will Provide Insight Into ACO-Based Reform
Program centered on coordinated care organization highlights challenges of contracting with ACOs
Wednesday, February 13, 2013

Selumetinib Ups Radioiodine Uptake in Thyroid Cancer
Increases radioiodine uptake and retention in patients with radioiodine-refractory disease
Wednesday, February 13, 2013

Diabetes Practice Patterns, Knowledge Gaps Identified
Findings presented for almost 1,000 health care providers who manage type 2 diabetes
Wednesday, February 13, 2013

Tedizolid Phosphate Viable for Bacterial Skin Infections
Tedizolid phosphate noninferior to linezolid in phase 3 trial, with good early clinical response
Wednesday, February 13, 2013

High Calcium Intake Linked to Increased Mortality in Women
Intake of >1,400 mg/day linked to increased all-cause, cardiovascular, but not stroke, mortality
Wednesday, February 13, 2013

Health Insurance Exchanges Are Top Priority on U.S. Agenda
Fifty-five percent view establishment of insurance exchange as top policy priority for their state
Wednesday, February 13, 2013

Potency of OTC Vitamin D Supplements Varies Widely
Over-the-counter pills from USP-verified manufacturers may have better accuracy
Tuesday, February 12, 2013

Maternal Folic Acid Use Linked to Reduced Autism Risk
Lower adjusted risk of autistic disorder but not other autism spectrum disorders
Tuesday, February 12, 2013

Study IDs Factors Associated With H. Pylori Eradication
Geographic site, demographics, adherence seem to be as important as antibiotic regimen
Tuesday, February 12, 2013

Naltrexone Linked to Reduction in Pain in Fibromyalgia
Low-dose treatment also improves mood and satisfaction with life
Tuesday, February 12, 2013

Use of Evidence-Based Meds Increasing for STEMI, NSTEMI
ACE inhibitor, antiplatelet and lipid-lowering therapies, beta-blockers, aspirin use increasing
Tuesday, February 12, 2013

Most Cardiac Patients Report Using Alternative Treatments
Almost half report interest in participating in research trials with CAM therapies
Monday, February 11, 2013

Brain Activity Linked to TNF Inhibitor Response in RA
Response to tumor necrosis factor inhibitors associated with activity in pain-related brain areas
Monday, February 11, 2013

Increasing Patient Activation Tied to Lower Health Care Costs
Having a higher score on the Patient Activation Measure linked to improved outcomes, lower costs
Monday, February 11, 2013

Statin Use Linked to Reduced Risk of Hepatocellular Cancer
Findings strongest in Asian populations, but also noted in Western populations
Monday, February 11, 2013

Long-Acting Daily Opioids Increase Risk of Hypogonadism
In men taking daily opioids, duration of action, but not dose, affects risk of hypogonadism
Friday, February 08, 2013

Most Dietary Supplement Use Not Recommended by Docs
Study looks at reasons motivating use of dietary supplements in adults
Friday, February 08, 2013

High Doses of Saw Palmetto Don't Impact Serum PSA
For men with lower urinary tract symptoms, saw palmetto has no effect on PSA versus placebo
Friday, February 08, 2013

ECT + SSRI Better for Major Depression Than Either Alone
Electrical current therapy plus sertraline more effective than either treatment alone
Thursday, February 07, 2013

Doctors' Perceptions of Psoriasis Therapies Vary
Beliefs on safety and efficacy vary; treatment preference not predictive of perceptions
Thursday, February 07, 2013

ASA: Pot Use May Be Linked to Increased Stroke Risk
Patients with ischemic stroke, transient ischemic attack more likely to have recently used cannabis
Wednesday, February 06, 2013

Rivaroxaban Found Noninferior to Enoxaparin in Acutely Ill
Extended-duration rivaroxaban has better efficacy than enoxaparin, but linked to increased bleeding
Wednesday, February 06, 2013

Corticorelin Acetate Has Steroid-Sparing Effect in Brain Cancer
In peritumoral cerebral edema, corticorelin acetate improves steroid-induced myopathy
Wednesday, February 06, 2013

Ramipril Improves Walking in Peripheral Artery Disease
Duration of pain-free and maximum walking increased; linked to improved physical function
Wednesday, February 06, 2013

Men's Risk of Kidney Stones Up With Ascorbic Acid Supplements
Dose-dependent effect seen with up to two-fold increased risk after multivariate adjustment
Wednesday, February 06, 2013

FDA Warns Consumers About Fraudulent Flu Products
Fraudulent products can be found online; include non-FDA-approved generic Tamiflu, Relenza
Tuesday, February 05, 2013

Antipsychotic Rx for 22 Percent of Nursing Home Residents
Based on prescribing patterns, off-label indications related to dementia likely
Tuesday, February 05, 2013

Exenatide Lowers BMI, Weight in Severely Obese Teens
Glucagon-like peptide-1 agonist linked to greater reduction in BMI, body weight versus placebo
Tuesday, February 05, 2013

Supplemental Calcium Tied to Higher CVD Death Risk in Men
Dietary calcium consumption not linked to cardiovascular disease death in men or women
Tuesday, February 05, 2013

Contraception Coverage Rules Issued for Public Comment
Proposed rules for contraception coverage with no cost sharing reflect feedback, religious concerns
Monday, February 04, 2013

CDC: Flu Activity Still Up in U.S. in Fourth Week of 2013
Pneumonia and flu-linked deaths above epidemic threshold; eight pediatric deaths reported
Monday, February 04, 2013

Stopping Aspirin Therapy After GI Bleed Ups Cardiovascular Risk
Risk of death or acute CV event is seven-fold higher for those who discontinue aspirin therapy
Monday, February 04, 2013

Medroxyprogesterone Acetate Linked to Immune Suppression
May affect responses to HIV by blocking HIV-1 coreceptors, increasing rate of HIV-1 replication
Friday, February 01, 2013

Tadalafil Improves Ejaculatory, Orgasmic Function
After treatment, residual ejaculatory or orgasmic dysfunction negatively impact sexual satisfaction
Friday, February 01, 2013

Low Diuretic Use in Home Care for Blacks With Hypertension
Despite guidelines, majority of blacks with uncontrolled hypertension don't receive diuretics
Thursday, January 31, 2013

Brain Activity Predicts Response to Scopolamine
Neural response in visual cortex after emotional stimuli predicts response in major depression
Thursday, January 31, 2013

CDC: Non-Flu Adult Vaccination Rates Largely Unchanged
Vaccination rates in 2011 and 2010 similar, except for modest increases in HPV in women, Tdap
Thursday, January 31, 2013

Peds Rotavirus Vaccine Offers Indirect Protection for Adults
About 50 percent drop in rotavirus prevalence for unvaccinated adults during peak disease season
Thursday, January 31, 2013

Kynamro Approved for Genetic Condition Tied to Cholesterol
Injection is an addition to lipid-lowering meds, diet in homozygous familial hypercholesterolemia
Wednesday, January 30, 2013

Single, Fractional Dose of Polio Vaccine Induces Priming
Seroconversion noted in more than 90 percent of infants, with two full or fractional doses
Wednesday, January 30, 2013

Bile Acid Sequestrant Reduces Glucose Concentration in T2DM
Colesevelam cuts fasting, postprandial glucose in subjects taking metformin; no effect on insulin
Wednesday, January 30, 2013

Flu Vaccine Safe in Children With Severe Egg Allergy
Single dose safe even in children with a history of anaphylaxis
Wednesday, January 30, 2013

Some Dietary Interventions Improve ADHD Symptoms
Fatty acid supplementation, elimination of artificial food colorings have positive effects
Wednesday, January 30, 2013

Parents Not Too Concerned About Child Abuse of Pain Meds
New poll shows that parents have lukewarm support for most policies to discourage misuse
Wednesday, January 30, 2013

Early Palliative Care in Lung CA Focuses on Coping, Symptoms
During critical time points or progression, palliative care emphasizes psychosocial aspects
Wednesday, January 30, 2013

Study Confirms Prolongation of QT Interval With Citalopram
Dose-response association with QTc prolongation for citalopram, escitalopram, amitriptyline
Wednesday, January 30, 2013

Moxifloxacin Monotherapy Equivalent to Antibiotic Combo
Findings among adult, febrile neutropenic cancer patients at low risk for complications
Wednesday, January 30, 2013

T1DM Insulin Intensification Patterns, Outcomes Studied
In youth studied, sociodemographics impact odds of switch; better outcomes with more intensive regimens
Tuesday, January 29, 2013

Even Correctly-Administered NSAIDS Can Cause AKI in Kids
Young children with NSAID-induced acute kidney injury may have more severe disease
Tuesday, January 29, 2013

Low Rate of Prostate Cancer Diagnosis After REDUCE
Over two-year follow-up, more cancers detected in men in dutasteride arm versus placebo arm
Tuesday, January 29, 2013

Placebo Often Effective for Treating Headache in Children
Second study suggests innovative trial strategies needed to reduce the placebo response rate
Tuesday, January 29, 2013

ER Visits Up for Misuse of ADHD Stimulants by Young Adults
Increase in number of visits among young adults, visits involving nonmedical use for ADHD meds
Tuesday, January 29, 2013

AAP Releases 2013 Child, Teen Immunization Schedule
2013 five-page format includes single schedule for children aged 0 to 18 years
Monday, January 28, 2013

Prehospital Antiplatelets Improve Graft Intervention Outcomes
Linked to fewer major adverse cardiac events after saphenous vein graft intervention
Monday, January 28, 2013

FDA: Three New Treatments Approved for Type 2 Diabetes
Nesina, Kazano, and Oseni, all based on alogliptin, approved for use with diet and exercise
Monday, January 28, 2013

FDA Panel Votes for Tougher Restrictions on Hydrocodone
Panel votes in favor of moving hydrocodone combo products into Schedule II category
Friday, January 25, 2013

Folic Acid Supplementation Has No Effect on Cancer Incidence
Over five years of supplementation, no significant effect on overall, site-specific cancer incidence
Friday, January 25, 2013

Marked Geographic Variation in Mental Health Medication Use
Clusters identified with elevated likelihood of antidepressant, antipsychotic, stimulant use
Friday, January 25, 2013

Physician Education Ups Communication for New Meds
Patients rate the new medication information transfer higher for docs in intervention group
Thursday, January 24, 2013

Peginesatide Safe for Anemia in Patients Undergoing Dialysis
Second study shows cardiovascular events and mortality up in patients not undergoing dialysis
Wednesday, January 23, 2013

Smoking Cuts Life Expectancy by More Than 10 Years
Can be partially reversed by quitting smoking
Wednesday, January 23, 2013

Fetal Exposure to Valproate Linked to Lower IQ at Age 6
Exposure to high doses of valproate, not other antiepileptics, linked to reduced cognitive abilities
Wednesday, January 23, 2013

FDA Approves Botox for Overactive Bladder
When patients don't respond to standard treatments
Tuesday, January 22, 2013

Aspirin Ups Risk of Age-Related Macular Degeneration
Association independent of cardiovascular disease, smoking, other risk factors
Tuesday, January 22, 2013

FDA: First Skin Patch Approved to Treat Migraines
Battery-powered transdermal system delivers sumatriptan; provides headache, nausea relief
Tuesday, January 22, 2013

Perceived Weight Gain Accurate for New Contraceptive Users
Implant users and depot medroxyprogesterone acetate users more likely to report weight gain
Tuesday, January 22, 2013

Most With C. difficile Receive Unnecessary Antimicrobials
One-quarter of patients with recent C. difficile infection received only unnecessary antibiotics
Monday, January 21, 2013

CDC: Flu Activity Continues to Be High Across the United States
Activity decreased in some areas during the second week of January
Friday, January 18, 2013

Efforts Failed to Up Primary Care, Rural Resident Training
Net growth in primary care training, but outpaced by growth in non-primary care training
Friday, January 18, 2013

Differences in Care for E-Visits, Office Visits for Sinusitis, UTI
Follow-up similar with both visits; more antibiotics prescribed, less preventive care with e-visits
Thursday, January 17, 2013

FDA: Flublok Approved to Prevent Seasonal Influenza
New vaccine doesn't use flu virus or eggs; could speed up production
Thursday, January 17, 2013

Short Course of ART Therapy Delays HIV Progression
Second study shows later initiation of ART decreases likelihood of CD4+ T-cell recovery
Thursday, January 17, 2013

Influenza Burden Remains High in Young Children
Less than 45 percent of children vaccinated despite expanded recommendations
Thursday, January 17, 2013

Influenza Vaccine in Pregnancy May Reduce Fetal Deaths
Decreased diagnosis of influenza and no increase in fetal mortality with maternal vaccination
Wednesday, January 16, 2013

Donor Fecal Infusion Effective for C. difficile Infection
Fecal infusion more effective for recurrent infection than vancomycin with, without bowel lavage
Wednesday, January 16, 2013

Even Brief Interruptions Dramatically Increase Errors
Error rate doubled or tripled in response to brief interruptions of only 2.8 to 4.4 seconds
Wednesday, January 16, 2013

Family Docs Are Early Adopters of Electronic Health Records
Sixty-eight percent currently use EHR systems; likely to surpass 80 percent by 2013
Wednesday, January 16, 2013

Alkylating Agent Linked to Therapy-Related Leukemia
Significant reductions seen with successive generations of Hodgkin's lymphoma therapy
Tuesday, January 15, 2013

Most Newly Approved Biologics Studied in Peds Population
Majority are currently labeled for pediatric use or involved in trial; similar findings for vaccines
Tuesday, January 15, 2013

Generic Three-Pill HIV Regimen Could Result in Big Savings
Increased lifetime costs of $42,500 with use of branded ART versus generic-based regimen
Tuesday, January 15, 2013

Decision Support Reduces Antibiotic Usage for Bronchitis
Similar results seen with print-based versus computer-assisted support strategies
Tuesday, January 15, 2013

Certain Online Behaviors of Docs Warrant Investigation
Consensus in seven of ten vignettes; outcome less clear for other doc online behavior scenarios
Monday, January 14, 2013

AAN: Cognitive Decline With Early-Age Surgical Menopause
Increased duration of hormone replacement therapy use linked to slower global decline
Monday, January 14, 2013

Top Five Issues for Docs and Patients Identified for 2013
Issues include access to care, physician shortages, preparation for 30 million new patients
Monday, January 14, 2013

Use of Beta-Blockers Tied to Improved Lung Cancer Survival
Overall, distant metastasis-free, and disease-free survival all improved for patients with NSCLC
Friday, January 11, 2013

CDC: Flu Activity Remains High in the United States
Early vaccine effectiveness estimates indicate moderate protection against the flu
Friday, January 11, 2013

Insulin LY2605541 Tops Glargine for Glycemic Control in T1DM
Better glycemic control, reductions in nocturnal hypoglycemia, weight, mealtime insulin dose
Friday, January 11, 2013

Malaria Drug Association With Hemolytic Anemia Unclear
CDC recommends following patients treated with artesunate for a month
Friday, January 11, 2013

National U.S. Health Care Spending Relatively Stable
But during 2011, personal health care spending growth accelerated
Friday, January 11, 2013

Etanercept Seems Beneficial in Partial Spinal Cord Injury
In rabbits, etanercept correlates with enhanced clinical and electrophysiological recovery
Thursday, January 10, 2013

CDC: Rare Blood Disorder Found in Intravenous Drug Users
Thrombotic thrombocytopenic purpura seen in patients who dissolve and inject oral pain medication
Thursday, January 10, 2013

Rate of Non-Medical Use of Rx Pain Meds 4.6 Percent
Considerable variation seen between states, from 3.6 percent in Iowa to 6.4 percent in Oregon
Thursday, January 10, 2013

SPIRIT 2013 Clinical Trial Protocol Guidelines Issued
Thirty-three-item SPIRIT checklist will serve as guideline for the minimum content of clinical trial
Thursday, January 10, 2013

FDA: Draft Guidance Issued on Abuse-Deterrent Opioids
To assist industry in developing new formulations of opioid drugs with abuse-deterrent properties
Wednesday, January 09, 2013

Two HTN Meds Plus NSAIDs Ups Acute Kidney Injury Risk
Risk up with use of diuretic and ACE inhibitor or angiotensin receptor blocker, plus NSAID
Wednesday, January 09, 2013

Acetaminophen Cuts Post-Op Morphine Use in Infants
Significant reduction in morphine requirements over 48 hours after major surgery
Wednesday, January 09, 2013

Vitamin D Does Not Improve Knee OA Progression, Symptoms
Supplementation to raise levels above 36 ng/mL has no impact on knee pain, cartilage volume loss
Wednesday, January 09, 2013

Failure Rate of Cefixime for N. gonorrhoeae Infection Explored
Increased risk of clinical treatment failure with minimum inhibitory concentration of ≥0.12 µg/mL
Tuesday, January 08, 2013

Number of Adults Using Walk-in Retail Clinics Increasing
Most users satisfied with care; but many are reluctant to use for more serious conditions
Tuesday, January 08, 2013

Methotrexate Offers Lasting Benefit in Juvenile Scleroderma
Clinical remission maintained for mean of 25 months for 72.9 percent of responders
Tuesday, January 08, 2013

Health Care Use Dropped Among All During Recession
Little evidence of racial or ethnic disparities, except for fewer physician visits for Hispanics
Tuesday, January 08, 2013

Metformin Cuts Cardio Events in High-Risk Type 2 Diabetes
Three-year treatment with metformin reduces cardiovascular events more than glipizide
Monday, January 07, 2013

Low Rates of High Platelet Reactivity With Prasugrel Tx
Low rates of HPR, ischemic events, major bleeds with prasrugel in acute coronary syndromes
Monday, January 07, 2013

Shared Savings May Promote Care Coordination Entity Use
Sharing savings with dually eligible patients may foster enrollment in coordinated care entities
Monday, January 07, 2013

CDC: Influenza Activity Increasing Across the U.S.
Proportion of deaths attributed to pneumonia and influenza below epidemic threshold
Friday, January 04, 2013

Nifedipine-Maintained Tocolysis No Benefit in Perinatal Outcomes
For threatened preterm labor, maintenance use of nifedipine not significantly better than placebo
Friday, January 04, 2013

Patient-Doctor Communication Affects Medication Adherence
Poorer communication ratings tied to lower adherence, especially for hypoglycemic medications
Friday, January 04, 2013

Distributing Naloxone to Heroin Users Likely Cost-Effective
Scenarios show lay administration would be cost-effective, even under conservative assumptions
Friday, January 04, 2013

Nurse-Led Monitoring Improves Cancer-Related Fatigue
Protocolized patient-tailored treatment of physical symptoms improves fatigue in advanced cancer
Friday, January 04, 2013

High-Dose Flu Vaccine Better Protects HIV-Infected Adults
Higher seroprotection for H1N1, H3N2, influenza B strains with high-dose versus standard-dose
Thursday, January 03, 2013

Eliquis Approved for People With Non-Valvular Atrial Fibrillation
To help prevent stroke and deadly blood clots
Thursday, January 03, 2013

Association Between Health Care Cost, Quality Inconsistent
Review of 61 studies shows inconsistent evidence for the direction of the association
Thursday, January 03, 2013

Fracture Risk Down With Adherence to Bisphosphonates
Second study shows more than half of U.S. vets with rheumatoid arthritis are non-adherent
Thursday, January 03, 2013

Interferon-Free Therapies for Hep C Virus Look Promising
Sofosbuvir plus ribavirin and ABT-450/ritonavir, ABT-333, ribavirin combos seem effective
Wednesday, January 02, 2013

No Significant Link for Stillbirth, Maternal Antidepressant Use
Certain maternal characteristics can account for increased deaths seen with SSRI use
Wednesday, January 02, 2013

Sirturo Approved for Multi-Drug Resistant Tuberculosis
Millions still contract the infectious disease each year
Wednesday, January 02, 2013

Fulyzaq Approved for ART-Related Diarrhea in HIV/AIDS
Not for HIV/AIDS patients with diarrhea due to infection or gastrointestinal disorder
Wednesday, January 02, 2013

House Joins Senate to Avert Medicare Cuts
U.S. health care could be significantly affected by failure to reach 'fiscal cliff' agreement
Wednesday, January 02, 2013

Administering Chemo Ups Income for Non-Salaried Oncologists
More research needed to understand impact of financial incentives on cost, quality of care
Wednesday, January 02, 2013

Teen Vitamin D Intake Not Related to Adult RA or SLE Risk
No link between dietary vitamin D intake during adolescence, rheumatoid arthritis, lupus risk
Thursday, December 27, 2012

Indicators Show Little Change in Overuse of Ambulatory Care
In U.S., improvement in six of nine underuse indicators; two of 11 overuse indicators
Thursday, December 27, 2012

Understanding of Infantile Hemangiomas Is Improving
New treatment options are available to minimize functional deformity, but risks need to be assessed
Thursday, December 27, 2012

Fertility Drugs Not Linked to Uterine Cancer Recurrence
Five-year disease-free survival similar for women who did or did not receive fertility drugs
Wednesday, December 26, 2012

FDA Recommends Against Drug to Treat Chronic Fatigue Syndrome
Advisory committee considered new analysis of trial data originally submitted in 2009
Friday, December 21, 2012

Varizig Approved to Reduce Chickenpox Symptoms
To be used within four days of exposure
Friday, December 21, 2012

FDA Expands Tamiflu Use to Treat Babies Under 1 Year Old
However, dose must be calibrated to weight
Friday, December 21, 2012

Data Suggest Smoking Doesn't Impact RA Treatment Response
No differences in mean disease activity score in 28 joints based on smoking status
Thursday, December 20, 2012

Fatty Acids Don't Reduce Atrial Fibrillation Recurrence
No significant difference from placebo for other outcomes, including stroke, MI, heart failure
Thursday, December 20, 2012

Metformin Treatment Beneficial for Obese Children, Teens
Twice-daily metformin improved body mass index SD score, metabolic risk factors, adipokines
Thursday, December 20, 2012

Two Drugs Promising for Juvenile Idiopathic Arthritis Treatment
Two studies show patients respond well to tocilizumab and canakinumab
Wednesday, December 19, 2012

Substantial Morbidity, Mortality From Fungus-Tainted Steroid
In 19 states, 590 cases of infection, 37 deaths tied to three lots of contaminated glucocorticoid
Wednesday, December 19, 2012

Vertex Announces Boxed Warning on Hepatitis C Drug
Decision prompted by reports of fatal cases of serious skin reactions with telaprevir treatment
Wednesday, December 19, 2012

Denosumab Does Not Delay Nonvertebral Fracture Healing
No delay of healing or contribution to other complications for postmenopausal women
Wednesday, December 19, 2012

Amoxicillin of Little Benefit in Lower-Respiratory Infection
Duration of symptoms, symptom severity not improved with amoxicillin in adults or older adults
Wednesday, December 19, 2012

Aspirin Use 10 Years Prior Tied to Incidence of Late AMD
Aspirin use linked to increased incidence of late, neovascular age-related macular degeneration
Tuesday, December 18, 2012

Workplace Bullying Linked to Psychotropic Medication Use
Experiencing or observing workplace bullying increase need for subsequent psychotropic meds
Tuesday, December 18, 2012

Adalimumab Relieves Hidradenitis Suppurativa
Once-weekly adalimumab reduces pain, inflammation in moderate-to-severe disease
Tuesday, December 18, 2012

AAP Urges United Nations Not to Ban Thimerosal in Vaccines
No evidence of harm from thimerosal; ban may reduce vaccine rates in developing countries
Monday, December 17, 2012

Health Care Satisfaction Rated As High by Unacculturated Hispanics
Unacculturated or biculturated Hispanics give higher ratings for health care experiences
Monday, December 17, 2012

Tenofovir Effectively Treats Adolescents With Chronic HBV
Once-daily tenofovir treatment is effective and well tolerated, regardless of prior treatment
Friday, December 14, 2012

Imeglimin Beneficial As Add-On to Metformin in T2DM
As add-on therapy, new oral agent improves glycemic control; generally well tolerated
Thursday, December 13, 2012

Racial/Ethnic Differences ID'd in HTN Medication Behaviors
Differences may be mediated by health system factors such as co-payment, mail order pharmacies
Thursday, December 13, 2012

Immunogenicity Strongly Impacts Response to Adalimumab in RA
For anti-TNF therapy-naive patients, overall efficacy similar for etanercept, adalimumab
Thursday, December 13, 2012

~40 Percent of Cancer Patients Receive Opioids at End of Life
In the U.K., patients older than 60 less likely to receive prescription versus those younger than 50
Thursday, December 13, 2012

FDA: Chantix May Raise Risk for Cardiovascular Events
FDA advises consideration of risks and benefits
Thursday, December 13, 2012

Teduglutide Seems Effective, Safe for Short Bowel Syndrome
Leads to a significant reduction in parenteral support compared with placebo
Wednesday, December 12, 2012

NSAIDs Exacerbate Exercise-Induced Small Intestinal Injury
NSAIDs induce gut barrier dysfunction in healthy athletes; extent of injury tied to barrier dysfunction
Wednesday, December 12, 2012

Any Amount of Smoking Ups Sudden Cardiac Death in Women
Dose-dependent relationship; even small-to-moderate amounts of smoking increase SCD risk
Wednesday, December 12, 2012

Benzodiazepines Linked to Higher Risk of Pneumonia
Benzodiazepine use also linked to increased 30-day and long-term mortality following pneumonia
Tuesday, December 11, 2012

Menopause Weight Gain May Up Breast Tumor Growth in Obese
Excess nutrients deposited in tumors of obese rats; tumors overexpress progesterone receptor
Tuesday, December 11, 2012

ASH: Extended Apixaban Cuts Risk of Recurrent VTE
Extending anticoagulation with apixaban 2.5 or 5 mg cuts risk without increasing major bleeding
Monday, December 10, 2012

Raised Risk of Ischemic Stroke in Women With A-Fib Explored
Gender-specific risk related in part to percent time in therapeutic range for warfarin
Monday, December 10, 2012

Concerns for Long-Term Safety of Antipsychotics in Over 40s
Lack of effectiveness, high incidence of side effects found for four common atypical antipsychotics
Friday, December 07, 2012

No Evidence That Doping Enhances Athletic Performance
Literature review fails to find evidence that rHuEPO enhances performance
Friday, December 07, 2012

Synergistic Risk of VTE for Women With PCOS Using the Pill
More than two-fold increased risk for women with PCOS who use combined oral contraceptives
Friday, December 07, 2012

Health Care Law Boosts Savings on Meds for Medicare Recipients
Savings on prescription drugs has reached $5.1 billion; for more than 5.8 million beneficiaries
Friday, December 07, 2012

Socioeconomic Status Affects Cancer Trial Referrals
Patients of lower socioeconomic status less likely to be referred to early-phase cancer trials
Thursday, December 06, 2012

Impact of HTN Meds on Cardio Risk Affected by Body Size
Thiazide-based treatment better for obese; amlodipine therapy effective across all BMI groups
Thursday, December 06, 2012

FDA Requests Removal of Generic Budeprion XL 300 mg
In head-to-head study, Budeprion XL 300 mg not bioequivalent to brand-name Wellbutrin XL 300 mg
Wednesday, December 05, 2012

FDA: Zofran 32-mg Dose Pulled From Market
The anti-nausea drug may cause serious heart problems at that dosage
Wednesday, December 05, 2012

Tetanus-Diphtheria-Pertussis Shot Deemed Safe for Seniors
No more adverse events seen with Tdap than with the Td vaccination in large study
Wednesday, December 05, 2012

Stimulant Still Available for Sale Despite FDA Action
DMAA marketed as a dietary supplement
Wednesday, December 05, 2012

Psychotropics Seem to Be Appropriately Prescribed to Teens
14.2 percent of sample of U.S. teens report being treated with psychotropic meds in past year
Tuesday, December 04, 2012

CDC: Flu Season Has Started and Hitting Hard
Levels of flu activity continue to increase nationally
Tuesday, December 04, 2012

Topical Simvastatin Accelerates Wound Healing in Diabetes
Acceleration is due to direct effect on lymphatics and indirect effects via macrophages
Monday, December 03, 2012

Epidural Steroid Shot Has Adverse Effect on Bone Density
Findings seen in postmenopausal women being treated for pain associated with radiculopathy
Monday, December 03, 2012

Recent Increase in Adverse TMP-SMX Reactions in Children
Significant increase from 2000 to 2009; coincident with increased use for skin, soft tissue infections
Monday, December 03, 2012

Fetal NSAID Exposure Not Tied to Persistent Pulmonary HTN
Neither NSAIDS overall, nor ibuprofen exposure tied to increased risk of hypertension of newborn
Monday, December 03, 2012

Increasing Number of Workers in Self-Insured Health Plans
In 2011, 58.5 percent with health coverage self-insured; increase driven by large employers
Monday, December 03, 2012

Model Predicts Flu Season Peak Seven Weeks in Advance
Based on data assimilation technique using data from the Web, flu peak predicted for New York City
Friday, November 30, 2012

Aspirin Use Cuts Risk of Hepatocellular Carcinoma
Nonaspirin NSAIDs, aspirin cut death due to chronic liver disease
Thursday, November 29, 2012

Orexin Receptor Antagonist Improves Sleep in Insomnia
Dose-related improvements in sleep efficiency, sleep induction, and maintenance
Thursday, November 29, 2012

Cigarette Tax Would Cost Federal Government in Long Term
Initial drop in spending to 2021, but increased longevity would ultimately increase spending
Wednesday, November 28, 2012

Political Leaders Face Voter Opposition to Medicare Cuts
Voter poll analysis portends conflict in ACA implementation
Wednesday, November 28, 2012

Digoxin Found to Increase Mortality in A-Fib Patients
Digoxin associated with a significant increase in deaths in patients with atrial fibrillation
Wednesday, November 28, 2012

Study Confirms Waning Immunity With Time Post-Pertussis Vaccine
Children with pertussis in California outbreak were less likely to have received five-dose DTaP series
Wednesday, November 28, 2012

Adding Fitness to Statin Rx Significantly Improves Mortality
In dyslipidemia, combo of statins, fitness results in greater reduction in mortality risk than either alone
Wednesday, November 28, 2012

Warfarin D/C Within 180 Days Post-Surgery May Up Mortality
CV death risk up with warfarin discontinuation within six months of valve replacement
Tuesday, November 27, 2012

Survival Benefit of Two Heart Failure Therapies Re-Examined
Studies examine aldosterone antagonists and renin-angiotensin system antagonists
Tuesday, November 27, 2012

Doc Earnings Growth Lags Behind Other Health Professionals
Adjusted physician earnings dropped by 1.6 percent from 1996-2000 to 2006-2010
Tuesday, November 27, 2012

Zolpidem Linked to Increased Risk of Inpatient Falls
Association persists after adjustment for multiple variables including age, insomnia, delirium
Tuesday, November 27, 2012

Growing Number of Drugs Possibly Inhibited by Grapefruit
All drugs orally administered; have low-to-intermediate bioavailability; metabolized by CYP3A4
Tuesday, November 27, 2012

Hemorrhage Rates Highest Within 30 Days of Warfarin Tx
For older patients with atrial fibrillation, rates highest in first 30 days of treatment
Monday, November 26, 2012

Ranbaxy Issues Recall of 41 Batches of Atorvastatin
Voluntary recall issued for specific batches of 10-, 20-, 40-mg atorvastatin calcium
Monday, November 26, 2012

AAP Addresses Emergency Contraception for Teens
Policy statement encourages pediatricians to give emergency contraception Rx in advance
Monday, November 26, 2012

Growth in Health Benefit Cost Per Employee Slowed in 2012
Workforce health management is strategy to cut costs, with incentives offered to up participation
Friday, November 23, 2012

For Patients With ADHD, Lower Criminality Rates With Med Use
Rates significantly down for men, women with ADHD receiving meds versus nonmedication periods
Wednesday, November 21, 2012

ACOG Advises Over-the-Counter Access for Oral Contraceptives
ACOG recommends over-the-counter availability to improve access to and use of oral contraceptives
Wednesday, November 21, 2012

Nearly 40 Percent of Adults Take Dietary Supplements
Most would continue taking them even if they were shown to be ineffective
Wednesday, November 21, 2012

Aspirin Resistance Ups Severity in Acute Ischemic Stroke
Increased stroke severity, infarct size linked to aspirin resistance in acute ischemic stroke
Wednesday, November 21, 2012

Testosterone Doesn't Add to Erectile Response With Sildenafil
Sildenafil + testosterone not superior for men with erectile dysfunction, low testosterone
Monday, November 19, 2012

Personality Traits Explain Some of Placebo Analgesic Effect
Resilient people have activation of endogenous painkillers in response to placebo after pain
Monday, November 19, 2012

Mental Illness, Job Stress Both Factors in Physician Suicides
Docs more likely to have antipsychotics, barbiturates, not antidepressants on toxicology testing
Friday, November 16, 2012

Optimal Dose Suggested for Dasatinib in Ovarian Cancer
Dasatinib in combination with paclitaxel and carboplatin shows some efficacy
Friday, November 16, 2012

Diltiazem Relieves Capecitabine-Induced Chest Pain
Prophylaxis with diltiazem prevents chest pain, allowing patients to tolerate capecitabine
Friday, November 16, 2012

Direct-to-Consumer Advertising Found Beneficial for Certain Meds
DTCA linked to increase in appropriate prescriptions of aromatase inhibitors for breast cancer
Friday, November 16, 2012

Ten-Valent Pneumococcal Conjugate Vaccine Effective
Different vaccine schedules are effective, including 2+1 schedule in infants
Friday, November 16, 2012

Trastuzumab Ups Cardiac Risk for Older Women With Breast Cancer
Treatment increases rates of heart failure, cardiomyopathy in early-stage breast cancer
Thursday, November 15, 2012

Study Provides Justification for L-DOPA in Angelman Syndrome
Dopamine release up in mesolimbic pathway, down in nigrostriatal pathway with L-DOPA treatment
Thursday, November 15, 2012

Venous Thromboembolism Risk Up With Cisplatin-Based Chemo
Meta-analysis shows elevated relative risk for cisplatin-treated patients with advanced solid tumors
Wednesday, November 14, 2012

Efficacy of Corticosteroid Injection for Sciatica Reviewed
Meta-analysis shows small short-term relief for leg pain, disability; however, little long-term benefit
Tuesday, November 13, 2012

Statin Use at Cancer Diagnosis Linked to Lower Mortality
All cause, cancer-related mortality down by about 15 percent for statin users at time of diagnosis
Wednesday, November 07, 2012

Triptorelin Doesn't Avert Early Ovarian Failure in Lymphoma
However, gonadotropin-releasing hormone agonist may protect ovarian reserve after chemotherapy
Wednesday, November 07, 2012

Guideline-Concordant Tx Cuts Mortality in Schizophrenia
Mortality also decreased with use of anti-Parkinson's medications, mental health visits
Wednesday, November 07, 2012

AHA: Peri-Op Omega-3s Don't Reduce Atrial Fibrillation
No reduction in the risk of a-fib for patients receiving peri-cardiac-op fish oil versus placebo
Wednesday, November 07, 2012

AHA: AMG145 Lowers LDL Levels in Statin-Intolerant
Subcutaneously administered monoclonal antibody to PCSK9 efficacious and tolerable
Wednesday, November 07, 2012

Study Compares Exenatide, Liraglutide for Type 2 Diabetes
Greater drop in glycated hemoglobin with liraglutide; adverse events occur less often with exenatide
Wednesday, November 07, 2012

AHA: Multivitamins Don't Reduce Cardiovascular Events
No decrease in MI, stroke, mortality in U.S. physicians followed for more than a decade
Tuesday, November 06, 2012

AHA: Social Cocaine Use Tied to Environment for Heart Attack
Users have higher systolic blood pressure, stiffer arteries, and thicker heart muscle walls
Tuesday, November 06, 2012

Sulfonylureas Up Cardio Events Versus Metformin
Sulfonylureas for initial treatment of diabetes linked to increase in composite of MI, stroke, death
Tuesday, November 06, 2012

Antirheumatic Drugs Have Minor Effect on Preeclampsia Risk
Increased risk for women with SLE; nonsignificant increased risk for DMARD users in pregnancy
Tuesday, November 06, 2012

AHA: Aspirin Doesn't Reduce Recurrence After First VTE
But results in significant reduction in rate of major vascular events, with improved net clinical benefit
Monday, November 05, 2012

FDA Approves Expanded Use of Xarelto
Use expanded to include treatment of deep vein thrombosis or pulmonary embolism
Monday, November 05, 2012

Drug Combo Active in Breast Cancer With Brain Metastases
Lapatinib plus capecitabine active for women with advanced HER2-positive breast cancer
Friday, November 02, 2012

Combo Therapy Can Be First-Line Approach in Manic Episodes
Combination therapy superior for efficacy, relapse prevention, with acceptable safety profile
Thursday, November 01, 2012

NSAIDS Don't Affect C-Reactive Protein Levels in RA Patients
Stratified analysis of specific NSAIDs show significant effect; naproxen tied to decrease in CRP
Thursday, November 01, 2012

Antidepressants Linked to Pregnancy Risks in Infertility Tx
No evidence of improved pregnancy outcome; counseling may be effective for depressive symptoms
Thursday, November 01, 2012

Anticoagulation Therapy Appears to Be Safe After TAVI
No increased risk of bleeding or other adverse outcome after receiving anticoagulant therapy
Thursday, November 01, 2012

Once-Yearly Zoledronic Acid Benefits Men With Osteoporosis
Significant drop in risk of new vertebral fractures, increased bone density, lower bone turnover
Wednesday, October 31, 2012

FDA: Ameridose Issues Voluntary Recall of All Products
All unexpired products should be returned to manufacturer
Wednesday, October 31, 2012

Single Topical Ivermectin Head Lice Treatment Very Effective
Ten-minute, at-home ivermectin treatment eliminates lice in nearly all patients by the next day
Wednesday, October 31, 2012

Only Omega-3s From Fish Tied to Lower Cerebrovascular Risk
Omega-3 fatty acids measured as circulating biomarkers, supplements not linked to lower risk
Wednesday, October 31, 2012

Latrepirdine Not Effective in Huntington's Disease
Six months of treatment does not improve cognition in patients with mild-to-moderate disease
Wednesday, October 31, 2012

U.S. Medicare Spending on Elderly Has Outpaced Canada's
Growth three times faster in the U.S., while Canada offers more comprehensive benefits
Tuesday, October 30, 2012

Resveratrol Has No Metabolic Benefit for Non-Obese Women
Does not affect its putative targets in fat or muscle in women with normal glucose tolerance
Tuesday, October 30, 2012

Buspirone Improves Symptoms in Functional Dyspepsia
Reduces symptom severity, slows liquid gastric emptying, and enhances gastric accommodation
Monday, October 29, 2012

More Intensive Chemo Ups Survival in Ewing Sarcoma
No increased toxicity with increasing chemo from every three weeks to every two weeks
Monday, October 29, 2012

Insulin Sensitivity Normally Highest After Breakfast
Increased beta-cell responsiveness to glucose, disposition index; lower hepatic insulin extraction
Friday, October 26, 2012

Meta-Analysis: Antivirals Reduce Risk of Liver Cancer in Hep C
Meta-analysis shows preventive effect more pronounced for virological responders
Thursday, October 25, 2012

Timing of Hormone Therapy Use Impacts Alzheimer's Risk
Women who start hormone therapy within five years of menopause have 30 percent reduced risk
Thursday, October 25, 2012

Aspirin Improves Survival for CRC With PIK3CA Mutation
Use of aspirin after diagnosis ups cancer-specific, overall survival for patients with mutated PIK3CA
Wednesday, October 24, 2012

Terminal Cancer Patients May Have Erroneous Chemo Beliefs
Patients who rate communication with their doctor favorably more likely to have inaccurate beliefs
Wednesday, October 24, 2012

Genuine Very Large Effects in Trials Rare in Medicine
Very large effects typically seen in small trials and diminish subsequently; seldom address mortality
Tuesday, October 23, 2012

Antihypertensive Medication Use, BP Control Up in U.S.
Multiple agent use up from 2001 to 2010; linked to increased likelihood of blood pressure control
Tuesday, October 23, 2012

TNF Inhibitor Use Doesn't Up Short-Term Cancer Incidence
In rheumatoid arthritis, inflammatory bowel disease, psoriasis, or psoriatic arthritis
Monday, October 22, 2012

HRT Not Recommended for Prevention of Chronic Conditions
Task force concludes that moderate harms of hormone replacement outweigh potential benefits
Monday, October 22, 2012

Higher Calcium Intake May Lower Risk of Hyperparathyroidism
Increased dietary calcium lowers risk of primary hyperparathyroidism in women
Friday, October 19, 2012

Stroke Risk Up With Serotonin Reuptake Inhibitor Use
Risk of intracerebral and intracranial hemorrhage is increased with exposure to SSRIs
Thursday, October 18, 2012

Linezolid Beneficial in Drug-Resistant Tuberculosis
Addition to background therapy effectively achieves culture conversion; high rate of adverse events
Thursday, October 18, 2012

AACR: Multivitamins Linked to Modest Drop in Cancer in Men
Nonsignificant trend for site-specific cancer reduction seen with daily multivitamin use by older men
Wednesday, October 17, 2012

Alzheimer's Symptoms Relapse Risk High After Halting Drug
Psychotic or aggressive patients responding to antipsychotic drugs at risk if drug is discontinued
Wednesday, October 17, 2012

AAPS: Intravaginal Ring Releases HIV Drug Over 90 Days
Tenofovir released steadily; similar to or better than gel administration in sheep model
Wednesday, October 17, 2012

Lipid Profiles Improved in Past Two Decades in United States
Improvements seen even in the obese and those not taking lipid-lowering drugs
Tuesday, October 16, 2012

High-Dose Vitamins Don't Halt HIV Progression, Death
High-dose supplement not beneficial for patients in Tanzania initiating HAART; may increase ALT levels
Tuesday, October 16, 2012

ASA: Illicit Drug Abuse Down, Prescription Drug Abuse Up
Emergency room data from 2007 to 2009 shows decreases larger in magnitude than increases
Tuesday, October 16, 2012

Zonisamide 400 mg Enhances Weight Loss for Obese
But high incidence of gastrointestinal, nervous system, and psychiatric adverse events
Monday, October 15, 2012

B-Vitamin Supplement Doesn't Lower Colorectal Cancer Risk
Combination of folic acid plus vitamins B₆, B₁₂ doesn't lower adenoma risk for high-risk women
Monday, October 15, 2012

Methotrexate Use Linked to Reduced Mortality in RA
Findings for methotrexate use of more than one year in cohort of patients followed for 25 years
Friday, October 12, 2012

Tadalafil Effective, Safe in Complete Erectile Dysfunction
Intercourse success rates of 32 to 46 percent achieved with tadalafil, with good tolerability
Friday, October 12, 2012

Seniors Overspending on Prescription Drug Plans
Medicare Part D beneficiaries overspend by hundreds per year due to difficulty selecting plan
Friday, October 12, 2012

PCI Linked to Increased Platelet Reactivity
Increase observed after percutaneous coronary intervention despite antiplatelet therapy
Friday, October 12, 2012

Leflunomide Considered Safe, Effective for Psoriatic Arthritis
Improvements seen in joint scores, pain, fatigue, dactylitis, and skin disease
Friday, October 12, 2012

Use of More Costly Diabetes Medications Varies Widely
Even within integrated VA system with set formulary and utilization management tools
Thursday, October 11, 2012

Social Media Influences Youth Sexual Behavior in Short Term
Positive effect seen in condom usage at two months, but not six months
Thursday, October 11, 2012

Prior Alcohol Consumption Does Not Impair HCV Treatment
Pretreatment drinking patterns, total alcohol intake unrelated to sustained virological response
Thursday, October 11, 2012

Study Confirms Link Between Analgesic Use, Ovarian Cancer
Case-control study shows any analgesic, aspirin use may reduce risk of ovarian cancer
Thursday, October 11, 2012

HIV Status Doesn't Influence Hodgkin's Lymphoma Outcome
In patients treated with ABVD chemotherapy, despite more extensive disease, worse prognosis
Thursday, October 11, 2012

New Cervical Cancer Vaccine Targets HPV-Infected Women
Early studies show that vaccine is well tolerated, immunogenic for women with prior neoplasia
Wednesday, October 10, 2012

Diverse Forms of Distress Have Distinct Impact in Diabetes
Depressive symptoms affect self-care behaviors; diabetes-related distress impacts glycemic control
Wednesday, October 10, 2012

Long-Term Ranibizumab Beneficial for Macular Edema
Reduces mean foveal thickness, improves visual acuity, but significantly more injections required
Wednesday, October 10, 2012

Hormone Replacement Therapy Initiated Early Deemed Safe
Ten years of HRT linked to reduced risk of composite of mortality, heart failure, MI
Wednesday, October 10, 2012

Review Compares Effectiveness of Tocolytic Agents
Prostaglandin inhibitors and calcium channel blockers most effective for delaying delivery
Wednesday, October 10, 2012

Cannabis Relieves Muscle Stiffness in Multiple Sclerosis
Oral cannabis extract provides nearly twice the rate of relief of placebo; also beneficial for pain
Wednesday, October 10, 2012

Belimumab Deemed Safe for Long-Term Treatment of Lupus
Over four years of exposure, adverse events were stable or declined
Tuesday, October 09, 2012

Low-Dose Aspirin Use Shows Neuroprotective Effect in Women
In older women at high risk for cardiovascular disease taking daily low-dose aspirin over five years
Tuesday, October 09, 2012

Prenatal Psychotropic Meds Affect Infant Language
Maternal mood, exposure to SRIs affect development of infant speech perception
Monday, October 08, 2012

Free Birth Control Substantially Lowers Abortion Rate
Reduction in repeat abortions; abortions, teen pregnancies down versus national rates
Monday, October 08, 2012

Larger Study Confirms Statins' Role in Preventing Cardiac Events
Most persistent users have lower risk of acute cardiac events versus nonpersistent users
Friday, October 05, 2012

Lower Glaucoma Risk for Statin Users With Hyperlipidemia
Statin use lowers risk of open-angle glaucoma, progression to OAG, need for treatment
Thursday, October 04, 2012

Limiting the Problem of Missing Data Urged for Clinical Trials
Special report: analysis methods can not compensate for missing data, simple fixes ruled out
Wednesday, October 03, 2012

Mexiletine Shows Promise for Rare Nondystrophic Myotonias
Improvement in patient-reported severity score of stiffness and quality of life with mexiletine
Wednesday, October 03, 2012

Cherry Intake Linked to Lower Risk of Recurrent Gout Attacks
Cherries or cherry extract linked to lower risk; additive effect when combined with allopurinol
Wednesday, October 03, 2012

High-Dose Vitamin D Does Not Prevent or Treat Colds
No reductions in days missed from work, duration of symptoms, or cold severity
Tuesday, October 02, 2012

Study Finds β-Blockers May Not Reduce Cardiovascular Event Risk
Findings in observational study of stable patients with, without coronary artery disease, prior MI
Tuesday, October 02, 2012

New Guidelines Issued for Management of Gout
Two-part guidelines include approaches to hyperuricemia; therapy, prophylaxis for acute gout
Tuesday, October 02, 2012

No New Safety Concerns for Gardasil in Young Females
No additional safety problems detected since its approval in 2006
Tuesday, October 02, 2012

Sexual Dysfunction Common With Aromatase Inhibitors
Unsatisfactory sex life, low sexual interest for about half of postmenopausal breast cancer patients
Monday, October 01, 2012

Melatonin Effective for Sleep in Patients Taking β-Blockers
No rebound sleep disturbance observed after discontinuing melatonin
Monday, October 01, 2012

Benzodiazepine Use Linked to Increased Risk of Dementia
Link robust after adjustment, across pooled studies over time, in nested case-control study
Friday, September 28, 2012

Topical NSAIDs Effective for Chronic Musculoskeletal Pain
Equivalent to oral NSAIDs in efficacy but with fewer adverse gastrointestinal effects
Thursday, September 27, 2012

Efficacy of Black Cohosh for Menopausal Symptoms Unclear
Does not reduce frequency of hot flashes versus placebo; insufficient evidence regarding safety
Wednesday, September 26, 2012

Drugs Similar in Efficacy for Neuropathic Pain in Diabetes
Amitriptyline, duloxetine, and pregabalin reduce pain; differ in sleep quality, adverse effects
Wednesday, September 26, 2012

Antibiotic Use Varies by Season, Geographic Region for Elderly
In older adults, antibiotic use highest in South, lowest in West, particularly in winter months
Wednesday, September 26, 2012

Limited Evidence on Medication Use for Youth With Autism
Review IDs lack of evidence on medication use for 13- to 30-year-olds with autism spectrum disorder
Monday, September 24, 2012

Childhood Antibiotic Exposure Linked to Development of IBD
Earlier exposure during childhood tied to even greater risk of inflammatory bowel disease
Monday, September 24, 2012

Duration of Antiplatelet Drugs for Drug-Eluting Stents Studied
Two studies show similar rate of cardiac events with/without discontinuation during first year
Thursday, September 20, 2012

Sequential Oral, Topical Tacrolimus Benefits Dermatitis
Pilot study shows benefits in assessments of atopic dermatitis disease control
Thursday, September 20, 2012

Progestogens Not Effective in Multiple Gestations
Treatment prevents preterm birth in singleton pregnancies but not in multiple gestations
Tuesday, September 18, 2012

VTE Risk Varies by Hormone Therapy Formulation
Highest VTE risk associated with oral estrogen-progestin formulations with medroxyprogesterone
Tuesday, September 18, 2012

L-Carnitine Does Not Reduce Cancer-Related Fatigue
No relief for patients with invasive malignancies given L-carnitine supplementation 2 g/day for four weeks
Tuesday, September 18, 2012

Resuming Warfarin After GI Bleed Cuts Mortality
Benefits of lower risk of thrombosis and death outweigh risks of new gastrointestinal bleed
Tuesday, September 18, 2012

Nicotine Replacement Doesn't Increase Cardio Risk After ACS
In year after acute coronary syndromes, no increase seen in cardiovascular events with NRT
Monday, September 17, 2012

Antipsychotic Use Up Among U.S. Medicaid-Enrolled Youth
By 2007, youth with ADHD accounted for half of total antipsychotic use
Friday, September 14, 2012

Risk of Car Accidents Up With Antidepressant Use
Benzodiazepines and Z-drug use also increases odds of car accidents, but not antipsychotic use
Friday, September 14, 2012

Long-Term Finasteride Doesn't Impair Quality of Life
No negative effects for men randomized to receive finasteride to prevent prostate cancer
Thursday, September 13, 2012

Meta-Analysis: Acupuncture Reasonable Chronic Pain Option
Effective relief for back and neck pain, osteoarthritis, and chronic headache
Thursday, September 13, 2012

Advertising Changes After Drug Switch to Over-the-Counter
After switch from prescription, less presentation of potential harms, generic names omitted
Thursday, September 13, 2012

Persistence of Statin Use Linked to Decreased Cancer Risk
Significant reduction in risk of hematopoietic malignancies for those with most persistent use
Wednesday, September 12, 2012

No Superior Method of Adjusting Inhaled Steroids in Asthma
Time to treatment failure similar for physician-, biomarker-, symptom-based strategies
Tuesday, September 11, 2012

Review: Omega-3s Do Not Reduce Risk of Cardio Events
Meta-analysis of 20 studies shows no correlation with mortality, cardiac mortality, MI, stroke
Tuesday, September 11, 2012

Less Alzheimer's Pathology With Angiotensin Receptor Blocker Use
Autopsies show less amyloid deposition markers for angiotensin receptor blocker-treated patients
Tuesday, September 11, 2012

Antihypertensive Use in Pregnancy Increasing
Prevalence close to 5 percent; some medications contraindicated in pregnancy are still used
Monday, September 10, 2012

NSAID Use Ups Cardiovascular Risk Up to Five Years Post-MI
Increased risk of death and coronary death or recurrent MI for NSAID users versus nonusers
Monday, September 10, 2012

Early Prophylactic Tx Beneficial for Hypertrophic Cardiomyopathy
Beta blockers reduce exercise-triggered left ventricular outflow tract obstruction
Monday, September 10, 2012

Antiretrovirals Increasingly Used for HIV in the U.S.
Viral load has decreased and CD4 counts have increased in the past decade
Friday, September 07, 2012

Not All Docs/Nurses Want to Be Asked About Hand Hygiene
Few were asked in the past month; more than a quarter do not want patients to remind them
Friday, September 07, 2012

Bolus Epidural Fentanyl Cuts Post-Spinal Decompression Pain
Intraoperative bolus epidural fentanyl improves early pain without significant side effects
Thursday, September 06, 2012

Intermittent ADT Noninferior to Continuous ADT for Prostate CA
For men with rising PSA after radiotherapy, survival similar for continuous, intermittent therapy
Wednesday, September 05, 2012

Anthracycline, Trastuzumab for Breast CA Up Heart Failure Risk
Risk of heart failure and/or cardiomyopathy up for women with incident, invasive breast cancer
Wednesday, September 05, 2012

Clopidogrel After MI Less Effective in Diabetes Patients
Less reduction in risk of all-cause, cardiovascular death in patients with diabetes versus without
Wednesday, September 05, 2012

No Increased Risk of Cancer With Biologics in Rheumatoid Arthritis
Use of biologic response modifiers for at least 24 weeks doesn't up overall, specific malignancy risk
Tuesday, September 04, 2012

Addition of Tiotropium Effective in Poorly Controlled Asthma
Beneficial effect seen for patients with poorly controlled asthma despite standard therapy
Tuesday, September 04, 2012

New Drug Approved for Irritable Bowel, Chronic Constipation
Linzess sanctioned for cases that don't respond to conventional treatment
Thursday, August 30, 2012

Lower Prostate Cancer-Specific Death With Anticoagulant Use
Aspirin primarily contributes to reduction for localized cancer treated with prostatectomy, radiotherapy
Thursday, August 30, 2012

Lung Cancer Risk Unaffected by Metformin Use in Diabetes
In nested-case control analysis, risk of lung cancer not lower in metformin-treated type 2 diabetes
Thursday, August 30, 2012

Similar Rate of CV Events With Atenolol, Metoprolol Tartrate
Rates of incident heart attack, stroke, heart failure similar for newly medicated patients with HTN
Thursday, August 30, 2012

Resistance to Second-Line TB Drugs Is Common Globally
Nearly half resistant to at least one drug; 6.7 percent have extensively drug-resistant TB
Thursday, August 30, 2012

Lacunar Stroke Outcomes No Better With Dual Antiplatelets
Clopidogrel plus aspirin doesn't reduce recurrent stroke risk; increases major bleeding and death
Wednesday, August 29, 2012

Long-Term Thrombosis Rates Similar for Drug-Eluting Stents
Similar rates of stent thrombosis seen at three years for zotarolimus- and sirolimus-eluting stents
Wednesday, August 29, 2012

New Class of Drugs Shows Promise for Heart Failure
Angiotensin receptor neprilysin inhibitor lowers NT-proBNP levels more than valsartan
Tuesday, August 28, 2012

LABA Withdrawal Increases Asthma-Related Impairment
Study looks at patients with asthma controlled by long-acting a2-agonist plus an inhaled corticosteroid
Tuesday, August 28, 2012

For Patients With Prior MI, Vorapaxar Cuts Cardiac Events
Addition to standard antiplatelet therapy reduces thrombotic events, but increases bleeding
Monday, August 27, 2012

Prasugrel, Clopidogrel Similar for Acute Coronary Syndromes
Frequency of primary end point, bleeding risks similar for those not undergoing revascularization
Monday, August 27, 2012

Muscle-Related Statin Effects Seem to Correlate With Potency
Fluvastatin is apparent exception to potency prediction of muscle-related adverse effects
Friday, August 24, 2012

Prolonged Dexamethasone Cuts Delayed Nausea After Chemo
Adding dexamethasone to prochlorperazine on days two and three reduces delayed nausea after chemo
Wednesday, August 22, 2012

Prior Substance Abuse Linked to Opioid Abuse in Young Men
In young women, only prior marijuana use is associated with prescription opioid abuse
Tuesday, August 21, 2012

Study Shows 'SuperAgers' Have Thicker Cortex, No Atrophy
Thicker cerebral cortex than aged-matched controls; no atrophy versus middle-aged controls
Monday, August 20, 2012

Pegylated Interferon Affects Growth, BMI in Children
Effects on weight-for-age and BMI generally reversible with cessation of therapy
Thursday, August 16, 2012

FDA: Codeine May Be Fatal in Subset of Children
Some children genetically predisposed to convert codeine to dangerous levels of morphine
Wednesday, August 15, 2012

Risk of Liver Injury Up With Certain Fluoroquinolones
Moxifloxacin and levofloxacin approximately double risk of acute liver injury in older people
Monday, August 13, 2012

Aspirin Use Again Linked to Slightly Lower Cancer Mortality
But, relationship may not be as strong as in previously reported pooled-data analysis
Monday, August 13, 2012

Statin Benefits Outweigh Risk of Developing Diabetes
Diabetes risk only increased in those with one or more major risk factors
Friday, August 10, 2012

Reasons for Discontinuation Vary by Psoriasis Treatment
Frequency of each of 11 cited discontinuation reasons varies significantly by treatment
Friday, August 10, 2012

Similar Mortality With Different TNF-α Inhibitor Therapies in RA
No mortality differences between adalimumab, etanercept, and infliximab in rheumatoid arthritis
Thursday, August 09, 2012

Vaccine Transiently Modifies Autoimmunity in Diabetes
Tuberculosis vaccine increases insulin production in patients with long-term type 1 diabetes
Thursday, August 09, 2012

Oral Corticosteroids Deemed Ineffective for Rhinosinusitis
No significant difference in symptom relief between steroid group and placebo group
Tuesday, August 07, 2012

Topical Treatment Shows Potential for Infantile Eczema
Cream containing 15(R/S)-methyl-lipoxin A₄ relieves severity of eczema, improves quality of life
Tuesday, August 07, 2012

Drug Helps Control Glucose in Congenital Hyperinsulinism
Glucagon-like peptide-1 receptor antagonist controls blood glucose and insulin levels
Tuesday, August 07, 2012

Photosensitizing Antihypertensive Meds Up Risk of Lip Cancer
Non-Hispanic whites treated long term with antihypertensives have increased odds of lip cancer
Tuesday, August 07, 2012

Sleep Duration Affects Hepatitis B Vaccine Response
Short sleep duration negatively impacts secondary antibody response and clinical protection
Monday, August 06, 2012

Exercise, Drugs Compared for Depression Tx in CHD Patients
Both exercise and sertraline effective; both tend to reduce heart rate variability
Thursday, August 02, 2012

Clinicians Can Unintentionally Prompt Nocebo Effect
Negative expectations, being informed about complications up likelihood of adverse effects
Thursday, August 02, 2012

Taxane-Induced Neuropathy Not Tied to Breast Cancer Outcome
In operable breast cancer, taxane-induced neuropathy not linked to survival, recurrence
Thursday, August 02, 2012

Caffeine Has Positive Effect on Motor Symptoms in Parkinson's
But limited effect on excessive daytime sleepiness
Wednesday, August 01, 2012

Higher Rates of Pertussis With Acellular Pertussis Vaccine
Children who receive mixed dose of DTaP and DTwP have higher rate if their first dose was DTaP
Tuesday, July 31, 2012

Levels of Etonogestrel Lower in Obese Women After Implant
Lower drug levels seen in obese women who receive a contraceptive implant
Tuesday, July 31, 2012

Donepezil Found Helpful in Dementia With Lewy Bodies
Improvement seen in cognitive, behavioral, global function when treated for 12 weeks at 5, 10 mg/day
Tuesday, July 31, 2012

'Bath Salts' Demonstrate High Potential for Abuse
Mice study shows mephedrone stimulates brain reward centers in similar manner to cocaine
Friday, July 27, 2012

Low-Dose Duloxetine Deemed Safe for Urinary Incontinence
Low incidence of adverse events in study of more than 12,000 women; no suicide attempts reported
Friday, July 27, 2012

Rituximab Useful in Idiopathic Membranous Nephropathy
Two-thirds of patients achieve remission and improved or stabilized renal function
Friday, July 27, 2012

Excess Maternal Iodine Linked to Congenital Hypothyroidism
Findings based on case studies of three infants and their mothers' nutritional supplement history
Thursday, July 26, 2012

Clopidogrel Response Remains Stable After Acute MI
For acute MI patients treated with PCI, response to clopidogrel therapy stable up to six months
Thursday, July 26, 2012

Selenium, Vitamins C, E May Lower Pancreatic Cancer Risk
Food diary data suggest higher antioxidant intake may cut pancreatic cancer risk by two-thirds
Thursday, July 26, 2012

Immunosuppressant Switch Cuts Skin Cancer Post-Transplant
Longer survival for kidney-transplant patients switched to sirolimus from calcineurin inhibitors
Wednesday, July 25, 2012

Vitamin E Intake Inversely Linked to Liver Cancer Risk
Vitamin E from diet or supplements may reduce the risk of developing liver cancer
Wednesday, July 25, 2012

Hair Loss Drug Shows Long-Term Sexual Side Effects
In most patients, finasteride-associated sexual dysfunction persists, even after drug discontinuation
Monday, July 23, 2012

HIV Drug-Resistance Up in Resource-Limited Settings
Increase in prevalence since antiretroviral rollout in regions of sub-Saharan African
Monday, July 23, 2012

Heart Medication Converts Cancer Cells Into Vaccine
Cardiac glycosides induce immunogenic cell death in cancer cells
Friday, July 20, 2012

Peri-Op Antidepressant Use Safe for Face-Lift Surgery
Serotonin reuptake inhibitor use in perioperative period safe; does not adversely affect outcome
Friday, July 20, 2012

Effect of Phosphate Binders in Chronic Kidney Disease Unclear
Linked to lower urinary, serum phosphorus, but promote progression of vascular calcification
Friday, July 20, 2012

Animal Study: Long-Term Ritalin Doesn't Impact Growth
Chronic methylphenidate treatment has no significant effect on growth measures, dopamine system
Friday, July 20, 2012

BMI Affects Aromatase Inhibitor-Linked Estrogen Suppression
Levels of estrogen up with letrozole, anastrozole for postmenopausal women with higher BMI
Friday, July 20, 2012

Poorer Patient Experience at Safety-Net Hospitals
Worse performance on nearly every measure of patient experience; discrepancy persisted over time
Thursday, July 19, 2012

~12,000 Preventable Deaths in English Hospitals Annually
Main causes are poor clinical monitoring, diagnostic errors, and inadequate drug/fluid management
Thursday, July 19, 2012

Social Network Analysis IDs Informal Physician Networks
Geographic variation in network characteristics; similar physician, patient features within networks
Tuesday, July 17, 2012

Aspirin Still First-Line Therapy for Unstable Angina/NSTEMI
Options for aspirin-intolerant include prasugrel (PCI-treated patients), ticagrelor, or clopidogrel
Monday, July 16, 2012

Nebivolol Better Preserves Exercise Performance at Altitude
Under acute exposure to high altitude hypobaric hypoxia, nebivolol better than carvedilol
Friday, July 13, 2012

Vitamin D Deficiency Linked to Poorer Lung Function in Children
Vitamin D levels should be monitored in children with asthma treated with inhaled corticosteroids
Friday, July 13, 2012

Chemo Combo Promising for Pancreatic Neuroendocrine Tumors
Greater benefit with temozolomide, bevacizumab for patients with pancreatic versus carcinoid NETs
Friday, July 13, 2012

Abuse-Deterrent OxyContin Produces Unexpected Outcome
OxyContin abuse down, but increase noted in use of alternative opioid medications and heroin
Thursday, July 12, 2012

Drug Reduces Graft-Versus-Host After Stem Cell Transplant
Chemokine receptor CCR5 antagonist maraviroc inhibits lymphocyte chemotaxis
Thursday, July 12, 2012

HIV Preexposure Prophylaxis With Antiretrovirals Explored
Value of prophylactic combination tenofovir-emtricitabine varies in three studies
Wednesday, July 11, 2012

Supplement Mixture Improves Memory in Mild Alzheimer's
Improvement seen both on cognitive tests and functional connectivity on EEG
Wednesday, July 11, 2012

Flu Shot in Pregnancy Not Tied to Adverse Fetal Outcomes
H1N1 flu vaccination linked to small but significantly increased risk of Guillain-Barré
Tuesday, July 10, 2012

Study Supports Chemo After Periampullary Cancer Surgery
Benefit only seen after adjusting for prognostic variables, not in primary analysis
Tuesday, July 10, 2012

Top Medical Organizations Support Hormone Replacement
HRT deemed safe and acceptable treatment for menopausal symptoms
Monday, July 09, 2012

Evidence of Herd Immunity After Introduction of HPV Vaccine
Significant drop in vaccine-type HPV in vaccinated, unvaccinated women
Monday, July 09, 2012

Unsuccessful Fertility Drug Use Lowers Breast Cancer Risk
Protective association disappears among women who successfully conceive on fertility drugs
Monday, July 09, 2012

Gestational Diabetes Risk Up With Antipsychotic Use
Risk of similar magnitude but not significant for those taking olanzapine and/or clozapine
Friday, July 06, 2012

Medicare Part D Gap Lowers Maintenance Antidepressant Use
Elderly with generic coverage reduce just their use of brand-name antidepressants
Friday, July 06, 2012

Obesity Is a Risk Factor for Poor Remission Rates in RA
Study looks at patients with long-standing rheumatoid arthritis treated with TNFα therapies
Friday, July 06, 2012

Early Intensive Diabetes Therapy Preserves β-Cell Function
β-cell function preserved for 3.5 years with insulin plus metformin or triple oral therapy
Friday, July 06, 2012

Dose-Escalated Cetuximab Tolerated in Colorectal Cancer
Possible improved response and disease control rates in irinotecan-refractory metastatic CRC
Thursday, July 05, 2012

Eltrombopag Linked to Clinical Response in Aplastic Anemia
Clinically significant multilineage response in some patients with severe refractory aplastic anemia
Thursday, July 05, 2012

High-Dose Vitamin D 'Somewhat Favorable' in Fracture Prevention
Benefits for elderly women consistent regardless of baseline levels, age, calcium intake
Thursday, July 05, 2012

Limited Evidence Links Pioglitazone to Bladder Cancer
Thiazolidinediones, specifically pioglitazone, may increase bladder cancer risk in type 2 diabetes
Tuesday, July 03, 2012

First Over-the-Counter HIV Test Approved
Results can be obtained within 40 minutes
Tuesday, July 03, 2012

Rheumatoid Arthritis Drug Not Linked to Specific Birth Defects
But authors advise use of contraception and avoidance of pregnancy while taking leflunomide
Tuesday, July 03, 2012

Hep B Screening Urged Before TNF-Alpha Inhibitor Therapy
Early, preemptive therapy can minimize hepatitis B reactivation; more reactivation with infliximab
Friday, June 29, 2012

Myrbetriq Approved for Overactive Bladder
Some 33 million Americans have the condition
Friday, June 29, 2012

Nelarabine Plus Chemo Viable in Children With T-Cell ALL
Nelarabine well tolerated; encouraging for pediatric patients with slow early response in T-cell ALL
Friday, June 29, 2012

Aspirin Use Linked to Reduced Risk of Barrett's Esophagus
Current aspirin users have a 44 percent lower risk of being diagnosed with Barrett's esophagus
Thursday, June 28, 2012

Supreme Court Upholds Health Care Reform Law
'Individual-mandate' insurance requirement deemed constitutional
Thursday, June 28, 2012

Omega-3 Supplements Reduce Inflammation in Overweight
Low- and high-dose omega-3 polyunsaturated fatty acids beneficial for healthy sedentary adults
Thursday, June 28, 2012

Linagliptin Noninferior to Glimepiride in Type 2 Diabetes
Significantly fewer patients have hypoglycemia, cardiovascular events with use of linagliptin
Thursday, June 28, 2012

FDA Clears First Weight-Loss Pill in 13 Years
Belviq designed to make people feel full sooner
Thursday, June 28, 2012

Duplicate Payments by Federal Government Increasing
Dually enrolled patients in the VA and Medicare account for substantial, duplicate costs
Wednesday, June 27, 2012

Early Start to ADHD Meds Lowers Risk of Academic Decline
Early initiation of stimulants linked to reduced academic decline in math, particularly for girls
Monday, June 25, 2012

Early Vaccinations Not Linked to Celiac Disease in Sweden
Changes in vaccinations don't account for epidemic; BCG vaccine linked to reduced risk
Monday, June 25, 2012

AHA: Vorapaxar Reduces Limb Ischemia in PAD
Does not reduce risk of cardiovascular death, myocardial infarction, stroke; ups bleeding risk
Friday, June 22, 2012

AHA: Concentrates Promising for Reversal of Apixaban
In vitro testing of three clotting agents demonstrates ability to reverse some effects of apixaban
Thursday, June 21, 2012

Genetic Contribution Detected in Responses to Opioids
Twin study shows significant inherited component for nausea, depressed breathing, drug liking
Thursday, June 21, 2012

Multi-Drug Regimens Cut HIV Transmission Versus Zidovudine
Second study shows virologic failure higher in infants treated with nevirapine versus lopinavir
Wednesday, June 20, 2012

Research Suggests Flavocoxid Causes Acute Liver Injury
Injury seen as mixed hepatocellular-cholestatic hepatitis beginning within one to three months of use
Tuesday, June 19, 2012

Belimumab Deemed Safe for Long-Term Lupus Treatment
In study, incidence rates of adverse events remained stable or declined over four-year follow-up
Tuesday, June 19, 2012

A Shift in Pediatric Drug Utilization Seen 2002 to 2010
Increased utilization of ADHD medication; decreased antibiotic, allergy medication use
Monday, June 18, 2012

Genetic Variants Predict Outcomes After t-PA Treatment
Two single nucleotide polymorphisms correlate with hemorrhagic transformation, in-hospital death
Monday, June 18, 2012

Review: Vitamin D Plus Calcium Linked to Mortality Reduction
Effect not seen for vitamin D alone in either individual patient data or trial level meta-analyses
Friday, June 15, 2012

Menhibrix Approved to Prevent Bacterial Infections in Infants
Approval covers infants and toddlers ages 6 weeks through 18 months
Friday, June 15, 2012

Testosterone Therapy Does Not Up Prostate Cancer Incidence
One case of cancer diagnosed per 212 years of testosterone replacement therapy
Friday, June 15, 2012

Mental Health Disorders Up Long-Term Opioid Use in Youth
About two-fold risk of long-term opioid use for youth with preexisting mental health disorders
Thursday, June 14, 2012

Statins Exhibit Adverse Effect on Energy, Exertional Fatigue
Randomized trial shows unfavorable effect of statins on energy and fatigue, particularly for women
Thursday, June 14, 2012

Cognitive Benefit of Omega-3s in Older Adults Questioned
Review finds that direct evidence on the effect of omega-3 PUFA on incident dementia is lacking
Thursday, June 14, 2012

Ethinyl Estradiol Dose, Progestin Type Affect the Pill's Stroke Risk
However, risk of thrombotic stroke and myocardial infarction is generally low for oral contraceptives
Wednesday, June 13, 2012

Life-Long Rx Not Always Needed for Juvenile Myoclonic Epilepsy
JME is heterogeneous syndrome; life-long treatment not always needed to maintain seizure freedom
Wednesday, June 13, 2012

Changes in Tumor Size by RECIST Correlate With Survival
Reflect linear continuum without clear boundary values or cutoffs to define response
Wednesday, June 13, 2012

Cannabinoid Formulation Benefits Opioid-Refractory Pain
Nabiximols offers pain relief for patients with advanced cancer, especially at low-dose
Wednesday, June 13, 2012

In Vitro Fertilization Linked to Multiple Sclerosis Relapse
Risk higher with failed IVF or with use of gonadotrophin releasing hormone agonists
Wednesday, June 13, 2012

Curbing Antibiotic Prophylaxis Doesn't Up Endocarditis Risk
No increase in infective endocarditis in high-heart risk dental patients since 2007 AHA guidelines
Wednesday, June 13, 2012

Task Force Questions Use of Vitamin D, Calcium Supplements
Government advisory panel finds insufficient evidence to support protective role of supplements
Tuesday, June 12, 2012

ADA: Salsalate Doesn't Up Endothelial Function in T2DM
No change in flow-mediated, endothelium-dependent dilation; lower Hb1Ac, inflammatory markers
Tuesday, June 12, 2012

ADA: Impact of Insulin Glargine on Cardio Outcomes Negligible
Modest weight gain and increase in severe hypoglycemia when compared to standard care
Tuesday, June 12, 2012

ADA: Hypo-Hyperglycemia Minimizer System Feasible
Two studies show system is able to predict changes in glucose and manipulate insulin delivery
Monday, June 11, 2012

Thiazolidinedione Use Linked to Diabetic Macular Edema
Increased risk seen at one- and 10-year follow-up; no difference for pioglitazone, rosiglitazone
Monday, June 11, 2012

ADA: Omega-3 Fatty Acids Don't Cut Cardiovascular Death
No significant effect seen for patients with dysglycemia and other cardiovascular risk factors
Monday, June 11, 2012

Marker Helps Predict Thrombotic Risk of Hormonal Contraceptives
For women taking hormonal contraceptives, sex hormone-binding globulin levels help estimate risk
Friday, June 08, 2012

Higher Risk of VTE in CKD Surgical Patients on Enoxaparin
Compared to desirudin, VTE risk up for enoxaparin-treated CKD stage 3B patients after THR
Friday, June 08, 2012

Multidrug-Resistance Seen in ~10 Percent of TB Cases in China
And, a new drug shows significantly improved sputum-culture conversion at two months
Wednesday, June 06, 2012

Anti-HTN Drugs Have Distinct Effect on Central, Brachial SBP
Central to brachial amplification lowered by beta blockers, thiazide diuretics, and omapatrilat
Wednesday, June 06, 2012

Many Adults May Accidentally Overdose on Acetaminophen
Limited literacy, heavy use of acetaminophen-containing products independently linked to risk
Wednesday, June 06, 2012

Aspirin Ups Risk of Bleeding in All But Diabetes Patients
Patients with diabetes have increased risk of major bleeding, independent of aspirin use
Tuesday, June 05, 2012

Head Lice Beginning to Show Permethrin Resistance
Approximately 14 percent of head lice in Parisian children resistant to the insecticide permethrin
Tuesday, June 05, 2012

In A-Fib, Rhythm Control Reduces Mortality in Long Term
Little difference within four years of initiation of rhythm, rate control; rhythm superior in long term
Tuesday, June 05, 2012

Many Patients Keep Using PPIs After Negative GERD Test
Nearly half of patients keep using proton pump inhibitors; most don't recall being told to stop
Tuesday, June 05, 2012

ASCO: Continuing Avastin With 2nd-Line Chemo Ups Survival
Findings in patients with metastatic colorectal cancer treated with first-line chemo plus Avastin
Tuesday, June 05, 2012

ASCO: Avastin Ups Survival in Platinum-Resistant Ovarian CA
Addition of bevacizumab to chemotherapy improves progression-free survival
Monday, June 04, 2012

Gene Variants Impact Smokers' Response to Cessation Therapy
High-risk haplotypes predict later age of smoking cessation; interact with treatment to affect success
Friday, June 01, 2012

Pioglitazone Use Ups Bladder Cancer Risk in Type 2 Diabetes
Highest risk for those with more than 24 months of exposure, cumulative dose of >28,000 mg
Friday, June 01, 2012

Adjunct Zinc Cuts Antibiotic Treatment Failure for Infants
Addition of zinc to antibiotics benefits infants aged 7 to 120 days with probable serious bacterial infection
Thursday, May 31, 2012

Cardiovascular Risk Counseling Improves Statin Adherence
Nurse-led counseling reduces anxiety; improved lipid profile seen for primary prevention patients
Thursday, May 31, 2012

Oral, Injected Methotrexate Have Similar Efficacy in JIA
Injected methotrexate could be discontinued in favor of oral administration in juvenile idiopathic arthritis
Wednesday, May 30, 2012

Online Adderall May Contain Wrong Active Ingredients
FDA warns that counterfeit drug may be ineffective and potentially harmful
Wednesday, May 30, 2012

Acne Medication Isotretinoin Increases Risk of Eye Disorders
Lack of lubrication, or dry eyes, may contribute to adverse ocular effects
Wednesday, May 30, 2012

NSAID Use Linked to Reduced Risk of Skin Cancer
Lower risk of squamous cell carcinoma, malignant melanoma; notably in long-term, high-intensity use
Tuesday, May 29, 2012

Evidence Updated for Impact of Menopausal Hormone Therapy
Updated review mainly based on evidence from 11 years of follow-up in Women's Health Initiative
Tuesday, May 29, 2012

PUFA Formula Supplementation Doesn't Up Infant Cognition
And, milk and soy formula fed infants have similar cognitive outcomes, slightly lower than breastfed
Tuesday, May 29, 2012

Upping Dietary Calcium Buys No Big Cardiovascular Benefit
Whereas calcium supplements linked to significant increase in risk of myocardial infarction
Friday, May 25, 2012

Common Therapies for Basal Cell Carcinoma Offer Similar Survival
Long-term tumor-free survival similar for imiquimod, photodynamic therapy
Friday, May 25, 2012

Magnesium Not Recommended After Subarachnoid Bleed
Randomized trial concurs with meta-analysis indicating no benefit for reduction of poor outcome
Friday, May 25, 2012

Low-Glucose Suspend Function in Insulin Pumps Deemed Safe
Findings based on overnight events with two-hour suspension with no adverse outcomes
Thursday, May 24, 2012

Vemurafenib, Dabrafenib Linked to Cutaneous Side Effects
Squamous cell carcinoma, warty dyskeratomas, verrucous keratoses, and other lesions can occur
Thursday, May 24, 2012

Brentuximab Vedotin Effective in Large-Cell Lymphoma
Complete remission for more than half with recurrent systemic anaplastic large-cell lymphoma
Thursday, May 24, 2012

DDW: Pancreatic CA Shot Added to Standard Therapy Ups Survival
In a related study, 4D-elastic light scattering fingerprinting probe detects pancreatic cancer
Thursday, May 24, 2012

Treatment With rt-PA Within Six Hours of Stroke Beneficial
Randomized trial, meta-analysis show benefit for wide range of patients with acute ischemic stroke
Wednesday, May 23, 2012

IUDs, Implants Most Effective for Preventing Pregnancy
Regardless of age, contraceptive failure rate higher among pill, patch, and ring users
Wednesday, May 23, 2012

Aspirin Effective in Preventing Thromboembolism Recurrence
For patients with unprovoked VTE, aspirin presents no apparent increase in risk of major bleeding
Wednesday, May 23, 2012

ATS: Anticholinergics May Up Arrhythmia Risk in Children
Finding raises concern regarding interest in the use of anticholinergics in asthma patients
Wednesday, May 23, 2012

Regorafenib Active in Metastatic GI Stromal Tumors
Significant activity for patients with advanced GIST after failure of imatinib and sunitinib
Wednesday, May 23, 2012

DDW: Estrogens Tied to Risk of Inflammatory Bowel Diseases
Studies show HRT increases risk of ulcerative colitis, oral contraceptives up risk of Crohn's
Tuesday, May 22, 2012

Chemoradiotherapy Improves Survival for Elderly With NSCLC
Addition of carboplatin to radiotherapy prolongs overall survival in locally advanced disease
Tuesday, May 22, 2012

Post-Stroke Inpatient Statins Improve Discharge Outcomes
After ischemic stroke, inpatient statin use increases likelihood of discharge to home or institution
Tuesday, May 22, 2012

Dabrafenib Safe, Active Against Some Metastatic Melanomas
Drug shows antitumor activity against Val600-mutant BRAF tumors at phase 2 dose of 150 mg
Monday, May 21, 2012

Sunscreen Ingredient May Be Linked to Risk of Endometriosis
Higher urinary concentration of benzophenone-type derivatives ups odds of endometriosis diagnosis
Friday, May 18, 2012

Gene Expression Profile Testing Increasing in Breast Cancer
Linked with decrease in chemotherapy in women with hormone receptor-positive breast cancer
Thursday, May 17, 2012

Generic Versions of Plavix Approved
Dispensed with Medication Guide that provides important instructions on use, drug safety
Thursday, May 17, 2012

IMFAR: Oxytocin Nasal Spray Promising in Youth With Autism
Functional MRIs show increased activity in brain regions known to process social information
Thursday, May 17, 2012

ASCO: For Chemo's Nausea, Olanzapine Beats Metoclopramide
Patients with breakthrough chemo-induced nausea and vomiting benefit from olanzapine
Thursday, May 17, 2012

ASCO: Abiraterone Tolerated in High-Risk Prostate Cancer
Good pathological complete/near complete response with abiraterone + leuprolide
Thursday, May 17, 2012

Statins Benefit Those at Low Risk for Vascular Events
Review shows benefit even for those with five-year risk of major vascular events of <10 percent
Thursday, May 17, 2012

Azithromycin Tied to Increased Risk of Cardiovascular Mortality
Increased risk of all-cause, cardio mortality; especially in those at risk for cardiovascular disease
Wednesday, May 16, 2012

Leukoencephalopathy Risk Factors ID'd for MS Drug
Risk with natalizumab treatment linked to JC virus status, immunosuppressants, treatment duration
Wednesday, May 16, 2012

Pazopanib Active in Metastatic Soft-Tissue Sarcoma
Progression-free survival up in metastatic non-adipocyte soft-tissue sarcoma, after chemo
Wednesday, May 16, 2012

U.S. Lifetime Prevalence of Sleep Walking ~30 Percent
More frequent episodes linked to obstructive sleep apnea; alcohol abuse; use of sleeping pills, SSRIs
Tuesday, May 15, 2012

Small Benefit of Inhaled Corticosteroids for Sinusitis
Review shows benefits may be greater at increased doses and with courses of several weeks duration
Tuesday, May 15, 2012

ECO: New Weight Loss Drug Effective in Advanced Obesity
Phentermine/topiramate linked to elevated weight loss; dose-response association noted
Monday, May 14, 2012

AHA: Clot-Busting Drug OK for Stroke Patients on Warfarin
No increased intracranial hemorrhage risk for acute ischemic stroke patients using warfarin
Monday, May 14, 2012

Post-SES Implantation, Statins Prevent Late Revascularization
Statins cut risk of late target lesion revascularization after sirolimus-eluting stent implant
Friday, May 11, 2012

AHA: Telemonitoring Improves Blood Pressure Control
Telemonitoring with pharmacist-directed therapy adjustments improves adherence, lowers BP
Friday, May 11, 2012

Blood Clot Risk Elevated in Patch and Vaginal Ring Users
Risk of venous thrombosis higher in non-oral contraceptives compared to oral contraceptives
Friday, May 11, 2012

HRS: Statins Reduce the Risk of A-Fib in Elderly With HTN
Statins are particularly effective for patients with CHADS₂ score of ≥2, other comorbidities
Friday, May 11, 2012

Rituximab Little Use in Resistant Idiopathic Nephrotic Syndrome
Drug does not reduce proteinuria in combination with prednisone, calcineurin inhibitors
Friday, May 11, 2012

Nonmedical Prescription Pain Medication Use Peaks at Age 16
Smaller peaks in pain med use to get high or for nonmedical purposes seen at 12-14, 19-21 years
Thursday, May 10, 2012

ECO: Normalizing Testosterone in Men Linked to Weight Loss
Testosterone shots linked to reduced BMI, waist circumference, BP, improved metabolic profile
Thursday, May 10, 2012

Avastin and Lucentis Equally Improve Visual Acuity in AMD
Taken monthly, the drugs have similar effects on age-related macular degeneration over two years
Wednesday, May 09, 2012

Epilepsy Treatment Response Patterns Usually Constant
Most patients with epilepsy have constant treatment course which can be predicted early
Wednesday, May 09, 2012

High Infection Rates Seen in Juvenile Idiopathic Arthritis
Oral glucocoticoids, but not methotrexate or TNF inhibitor use linked to increased infection
Wednesday, May 09, 2012

Pediatric Content in Drug Labeling Has Increased
But only 46 percent of drugs listed in the Physicians' Desk Reference have pediatric information
Wednesday, May 09, 2012

Metformin May Have Dual Effect in Breast Cancer
Ki-67 affected differently based on insulin resistance, particularly in luminal B tumors
Wednesday, May 09, 2012

Probiotics Helpful in Reducing Antibiotic-Related Diarrhea
More research needed to determine which probiotics are effective for specific antibiotics
Tuesday, May 08, 2012

Tenofovir Disoproxil Fumarate Doesn't Impact Fetal Growth
Anti-HIV drug doesn't affect newborn size, but may delay growth during first year
Tuesday, May 08, 2012

Zinc May Shorten Duration of Common Cold in Adults
Symptoms reduced in adults, but not children; bad taste, nausea are common adverse effects
Monday, May 07, 2012

Modified Fluorene Compound Potently Disrupts Amyloid-β
Fluorene modified with pyrroline nitroxide has antioxidant properties, disrupts Aβ oligomers
Monday, May 07, 2012

Resistance Patterns of Urinary E. coli Isolates Changing
2000 to 2010 saw considerable increase in resistance to ciprofloxacin, TMP-SMX
Monday, May 07, 2012

Lupus Nephritis Screening and Management Guidelines Issued
Include methods for identifying disease, new therapies, and treatment of pregnant patients
Friday, May 04, 2012

Complementary Medicine Not Tied to Prostate Cancer Outcome
Complementary, alternative medicine widely used; no effect on treatment satisfaction, outcomes
Friday, May 04, 2012

Antipsychotic Maintenance Rx Aids Schizophrenia Patients
But benefits of antipsychotic maintenance therapy need to be weighed against risk of side effects
Thursday, May 03, 2012

CDC: Teen Birth Rate Decreasing in United States
Decrease from 1990 to 2006-2010 may reflect an increase in the proportion of abstinent females
Thursday, May 03, 2012

Erlotinib Plus Chemo Doesn't Improve Efficacy in NSCLC
Offers no benefit for never or light former smokers with advanced non-small-cell lung cancer
Wednesday, May 02, 2012

Chemo Combination Promising for Multiple Myeloma
Elotuzumab, lenalidomide, low-dose dexamethasone well tolerated in relapsed/refractory MM
Wednesday, May 02, 2012

Methodological Heterogeneity Seen in Clinical Trials
Trials registered with ClinicalTrials.gov from 2007 to 2010 mainly small, single-center
Tuesday, May 01, 2012

PAS: Maternal Opioid Use, Neonatal Withdrawal Rising
Increase in neonatal abstinence syndrome from 2000 to 2009 accompanied by increase in hospital costs
Monday, April 30, 2012

Electronic Reminders Up Meds Adherence in Short Term
Electronic reminders, especially SMS reminders, are effective in short term for chronic medications
Monday, April 30, 2012

Levaquin Approved to Treat or Prevent Plague
Deadly disease rare in the United States
Monday, April 30, 2012

PAS: Combined Treatment Ups Glycemic Control in Young
Rosiglitazone plus metformin beats metformin alone or lifestyle interventions in adolescents with T2DM
Monday, April 30, 2012

AAN: Migraine Prevalence Up in Celiac Disease, IBD Patients
U.S. study finds self-classified gluten-sensitive individuals have increased odds of migraines
Friday, April 27, 2012

Excessive Neutropenia for Weekly Everolimus + Docetaxel
Dose-limiting neutropenia, variable drug clearance for patients with metastatic breast cancer
Friday, April 27, 2012

Accelerated Aging Evident in Cocaine-Dependent Individuals
Age-related gray matter volume loss occurs at twice the normal rate
Thursday, April 26, 2012

Modulator of mGluR5 Improves Features of Autism in Mice
GRN-529 reduces repetitive behaviors and partially reverses lack of sociability
Thursday, April 26, 2012

AHA: Similar Stroke Risk on Stopping Rivaroxaban, Warfarin
Similar, high stroke risk for patients with a-fib who temporarily or permanently discontinue meds
Thursday, April 26, 2012

Hyperalgesia Similar With Drug Therapies for Heroin Addiction
Once stabilized in treatment, no difference in pain response for methadone or buprenorphine
Thursday, April 26, 2012

Botox Modestly Improves Chronic Headaches, Migraines
But is not associated with reduction in frequency of episodic migraine or tension-type headaches
Wednesday, April 25, 2012

Meds, Clinic Noncompliance Linked to Mortality in Diabetes
Medication, clinic appointment noncompliance ups mortality in insulin-treated type 2 diabetes
Tuesday, April 24, 2012

AAN: Recommendations for Migraine Prevention Issued
Frequency and severity of migraine attacks can be reduced using seizure drugs and beta-blockers
Monday, April 23, 2012

Angiotensin Receptor Blockers Reduce No-Reflow Post-PCI
For patients with acute MI, ARB pretreatment is significant predictor of reduced no-reflow
Monday, April 23, 2012

Efficacy of Serotonin Receptor Inhibitors in Autism Unclear
Meta-analysis finds evidence SRIs help repetitive behaviors; results may be due to publication bias
Monday, April 23, 2012

Shingles Vaccine Generally Well Tolerated in Older Adults
Small, but significant, increased risk of allergic reaction in days one to seven following vaccination
Monday, April 23, 2012

Metformin + Insulin Comparable to Insulin Alone in T2DM
More data needed to determine whether combined use of oral therapy and insulin adds benefit
Friday, April 20, 2012

Study Compares Effectiveness of Psoriasis Treatments
For patients with plaque psoriasis, treatment effectiveness may be lower than seen in trial settings
Friday, April 20, 2012

AAN: Drug Reduces Progression to Clinically Definite MS
Taking interferon β-1a soon after a clinical event for possible MS delays progression to clear diagnosis
Thursday, April 19, 2012

Chemoradiotherapy Combo Ups Bladder Cancer Control
Locoregional control of muscle-invasive bladder cancer improved without additional toxicity
Wednesday, April 18, 2012

Albendazole Cuts Enteric Parasite Prevalence in Refugees
Presumptive predeparture single-dose albendazole reduces intestinal nematodes in refugees
Wednesday, April 18, 2012

FDA: Clinicians Urged to Stop Using Certain Ultrasound Gel
Specific lots found to have been contaminated by bacteria; 16 patients known to be affected
Wednesday, April 18, 2012

New Treatment Offers Benefit for Hypoxic Laryngeal Tumors
Accelerated radiotherapy plus carbogen and nicotinamide improves regional, not local, control
Wednesday, April 18, 2012

Medicare Coverage Gap Leads to Drug Discontinuation
About 57 percent of Medicare Part D patients stop taking cardiovascular drugs in coverage gap
Wednesday, April 18, 2012

AAN: Intestinal Gel Improves 'Off' Time in Parkinson's
Levodopa-carbidopa gel offers significant improvements versus immediate release tablets
Wednesday, April 18, 2012

ICD-9 Codes Underestimate Statin-Linked Rhabdomyolysis
Use of validated cases instead of ICD-9 code results in higher relative risk for high-dose statins
Tuesday, April 17, 2012

Preexposure Chemoprophylaxis Cuts HIV Infection at a Cost
Targeted prophylaxis strategy most cost-effective in highest risk men who have sex with men
Tuesday, April 17, 2012

Evidence Lacking for Value of CKD Screening and Monitoring
Variable quality of evidence found for effect of chronic kidney disease treatment options
Tuesday, April 17, 2012

AAN: Drug Reduces Brain Lesions in Multiple Sclerosis
Investigational drug is well tolerated in patients with relapsing-remitting MS
Monday, April 16, 2012

Low Gastroprotective Drug Adherence Ups Upper GI Events
Increased risk of events in patients taking coxibs with low adherence to gastroprotective agents
Monday, April 16, 2012

Alcohol Use With Opioids Common Even Without Abuse Past
Concurrent use of CNS depressants can lead to respiratory depression or sedation
Monday, April 16, 2012

Metal Binding Important for Metformin Action
Mechanism of action may involve copper binding
Friday, April 13, 2012

Crizotinib Treatment Lowers Total Testosterone Levels
In men with non-small-cell lung cancer, crizotinib rapidly suppressed testosterone levels
Friday, April 13, 2012

Pegaptanib Reduces Foveal Thickness in Macular Edema
Concomitant improvement in visual acuity, macular sensitivity, color discrimination in diabetes
Friday, April 13, 2012

Sequencing Traditional Chinese Medicines Reveals Surprises
Ingredients include potentially toxic plants and traces of endangered animals
Friday, April 13, 2012

Role of Omega-3 in Secondary Prevention of CVD Questioned
Meta-analysis finds inconclusive evidence of benefit in secondary prevention of cardiovascular events
Thursday, April 12, 2012

Bevacizumab Offers Lasting Improvement in Macular Edema
Best-corrected visual acuity significantly improved at two years for patients with diabetes-related CSME
Thursday, April 12, 2012

Antidepressants Don't Worsen Parkinson's Symptoms
Paroxetine and venlafaxine XR effectively treat depression in Parkinson's patients
Wednesday, April 11, 2012

Death Risk Similar With High-Dose Losartan, Candesartan
For patients with heart failure, low- or medium-dose losartan linked to increased mortality
Tuesday, April 10, 2012

Injectable Contraceptive Linked to Elevated Breast Cancer Risk
Recent use of depo-medroxyprogesterone acetate for 12 months or longer may double risk
Tuesday, April 10, 2012

Alternative Medicine Doesn't Affect Asthma Care in Children
Pediatric asthma patients have high med adherence regardless of alternative medicine
Tuesday, April 10, 2012

Report Highlights Child Deaths From Post-Surgery Codeine Use
Genetic variants produce ultra-rapid metabolizer phenotypes tied to respiratory arrest
Monday, April 09, 2012

Statins Moderate Effect of Metformin on Prostate Cancer
Taking both metformin and statins significantly reduces the incidence of prostate cancer
Monday, April 09, 2012

Treating Hepatic Encephalopathy Reduces Costs Due to MVAs
Diagnosis and lactulose treatment linked to reduced motor vehicle accident-related costs
Friday, April 06, 2012

Immunotherapy Tied to Lower Alzheimer's CSF Biomarkers
Anti-β-amyloid monoclonal antibody, bapineuzumab, linked to decreases in T-tau, P-tau
Friday, April 06, 2012

Antibiotics Safe and Effective to Treat Appendicitis
Meta-analysis indicates initial treatment with antibiotics may reduce the need for appendectomy
Friday, April 06, 2012

Full Weight-Based Chemo Doses Recommended for Obese
ASCO committee finds no evidence of increased short- or long-term toxicity in obese patients
Thursday, April 05, 2012

Prenatal Antipsychotics Impact Infant Neuromotor Function
Exposure to antipsychotics adversely affects neuromotor function in 6-month-old infants
Thursday, April 05, 2012

New Combination Malaria Treatment Equally Effective
Pyronaridine-artesunate as effective as mefloquine plus artesunate for uncomplicated malaria
Thursday, April 05, 2012

New Guidelines Issued for Rheumatoid Arthritis Treatment
Update of 2008 guidelines addresses screening for TB, immunization, treatment in high-risk patients
Thursday, April 05, 2012

Medical Malpractice Claims Incur Substantial Defense Costs
Costs higher for claims resulting in indemnity payments; significant variation by specialty
Wednesday, April 04, 2012

Reduced-Intensity Chemo Effective in Hodgkin's
Six cycles of BEACOPP_escalated more effective and less toxic than eight cycles
Wednesday, April 04, 2012

Alcohol, Drug Use Prevalent Among U.S. Adolescents
Onset of alcohol abuse seen at median age of 14 years; drug abuse onset at 14 or 15 years
Wednesday, April 04, 2012

Cetuximab With Chemo Doesn't Improve Colon Cancer Outcome
For stage III resected colon cancer, disease-free survival no better than with mFOLFOX6 alone
Tuesday, April 03, 2012

Fluoroquinolone Use Linked to Retinal Detachment
Current use of oral antibiotic linked to increased detachment risk, but absolute risk is small
Tuesday, April 03, 2012

Neupro Approved for Advanced Parkinson's and Restless Leg Syndrome
Thought to stimulate brain receptors governing movement
Tuesday, April 03, 2012

Serious Eye Disease Linked to Bisphosphonate Use
First-time oral bisphosphonate users at higher risk of developing uveitis and scleritis
Monday, April 02, 2012

AACR: Study Links Long-Term Estrogen Use to Breast Cancer
Risk increased with estrogen, estrogen + progesterone; no increase in fatal breast cancer
Monday, April 02, 2012

AACR: Metformin May Benefit Prostate Cancer Patients
Metformin may improve prostate-specific antigen levels and slow cancer growth
Monday, April 02, 2012

Similar Rates of Depression After Stroke and TIA
High frequency of newly identified depression; many with depression not appropriately treated
Friday, March 30, 2012

Statin Discontinuation Linked to Mortality in RA Patients
Increases risk of cardiovascular, all-cause death; suggests importance of treatment compliance
Thursday, March 29, 2012

Prophylaxis With Apixaban Feasible for Cancer Patients
Phase II study shows Factor Xa inhibitor safe and tolerated in chemotherapy-treated patients
Thursday, March 29, 2012

Cost Sharing Reduces Use of Asthma Medication
Results in increased frequency of asthma-related hospitalizations in children age 5 or older
Tuesday, March 27, 2012

Diagnosis of ADHD Has Risen 66 Percent Over Last Decade
More than 10 million children and adolescents diagnosed with ADHD in 2010 in the United States
Tuesday, March 27, 2012

Confusion About Emergency Contraception Access Common
Most misinformation related to what age women and teens can take it without a prescription
Monday, March 26, 2012

Health Care Team Members Key for Antimicrobial Stewardship
Epidemiologists, preventionists help stop infections caused by multidrug-resistant organisms
Thursday, March 22, 2012

Tenecteplase Superior to Alteplase for Stroke Treatment
Preliminary data show improved reperfusion, significant clinical improvements in select patients
Wednesday, March 21, 2012

Regular Aspirin Use Can Lower Cancer Risk, Studies Confirm
Lowers risk of esophageal, gastric, biliary, and breast cancer; reduces distant metastases
Wednesday, March 21, 2012

Dexmedetomidine Non Inferior for Maintaining Sedation
Dexmedetomidine not inferior to midazolam or propofol during prolonged mechanical ventilation
Wednesday, March 21, 2012

Vitamin E Does Not Reduce Risk of Heart Failure in Women
Long-term treatment not linked to heart failure risk in initially healthy women
Tuesday, March 20, 2012

Nurse-Initiated Steroids Improve Pediatric Asthma Care
In pediatric ER, time to clinical improvement and discharge shortened for children with asthma
Tuesday, March 20, 2012

Synthetic Cannabinoid Toxicity Among Teenagers on the Rise
Case reports describe signs, symptoms, and treatment in teen patients
Monday, March 19, 2012

Poorer Health Literacy Linked to Increased Mortality
About one-third of older adults in England have medium or low functional health literacy
Friday, March 16, 2012

Analgesic Use After Surgery Linked to Long-Term Use
Prescription of opioids, NSAIDs within seven days of low-risk surgery increases risk of long-term use
Thursday, March 15, 2012

Higher Spending by Hospitals Improves Outcomes
Lower mortality, readmission for acute patients admitted to hospital in highest tercile of spending
Tuesday, March 13, 2012

U.S. Mortality Rates Dropped 60 Percent From 1935 to 2010
For every year, heart disease, cancer, and stroke are among the five leading causes of death
Tuesday, March 13, 2012

Flu Vaccine Up Among Medical Staff When They Believe It Works
Hospital health care workers more likely to get vaccinated when committed to preventing flu
Friday, March 09, 2012

Buprenorphine Maintenance Therapy Not Recommended
Abstinence-based therapy recommended instead for opioid-addicted health care professionals
Thursday, March 08, 2012

Cognitive Benefits With Continued Donepezil in Alzheimer's
For moderate or severe disease, benefits seen with continued treatment, alone or with memantine
Wednesday, March 07, 2012

Financial Burden of Medical Care Affects One in Three
More than one in five poor or near-poor adults younger than 65 have bills they are unable to pay
Wednesday, March 07, 2012

Veterans With Mental Health Issues Receive More Opioids
Risks of opioid use and adverse clinical outcomes especially high in veterans with PTSD
Tuesday, March 06, 2012

Dutasteride Doesn't Alter Anabolic Effects of Testosterone
No significant difference found for men taking testosterone with dutasteride or with placebo
Tuesday, March 06, 2012

AAAAI: 2000 to 2009 Saw Rise in Angioedema Hospitalizations
Increase especially high for African-Americans; often due to adverse effects of ACE inhibitors
Tuesday, March 06, 2012

AAAAI: Corticosteroid Response in Asthma Impacted by BMI
For children, high BMI linked to decreased CS response, increased requirement for inhaled CS
Monday, March 05, 2012

Youngest in Class More Likely to Be Diagnosed With ADHD
Boys and girls born in December more likely to be diagnosed and treated for ADHD
Monday, March 05, 2012

Prenatal Ecstasy Use May Harm Infant Development
Use of ecstasy during pregnancy impacts fetal and early infant development
Monday, March 05, 2012

Drug Relieves Opioid-Induced Constipation in Critically Ill
Methylnaltrexone improves bowel function compared with conventional rescue laxatives
Monday, March 05, 2012

Parent Training, Meds Combo Improves Behavior in PDD
Modest extra benefit for children with pervasive developmental disorders, behavioral problems
Friday, March 02, 2012

Phone Counseling Doesn't Up Osteoporosis Meds Adherence
No improvement in osteoporosis medication adherence in elderly, predominantly female cohort
Thursday, March 01, 2012

Vandetanib Doesn't Up Survival in Non-Small-Cell Lung Cancer
For patients with advanced NSCLC, no survival benefit; increased frequency of adverse events
Thursday, March 01, 2012

Nicotine Patches Don't Help Pregnant Women Stop Smoking
User compliance is low and rates of smoking abstinence do not increase with the patch
Wednesday, February 29, 2012

Statin Users Less Likely to Suffer From Depression
Patients with coronary heart disease who use statins have a lower risk of depression
Wednesday, February 29, 2012

Despite Benefits of Selenium, Supplements May Be Harmful
Supplements not indicated for those with selenium concentration of 122 µg/L or higher
Wednesday, February 29, 2012

Sleeping Pill Use Linked to Greater Mortality Risk
Greater than three-fold higher risk even for fewer than 18 pills a year
Tuesday, February 28, 2012

FDA Approves Label Changes for Statins
Cognitive and blood sugar side effects added; recommendation of routine liver monitoring dropped
Tuesday, February 28, 2012

Heartburn Controlled With Step Down to Once Daily Therapy
Once-daily dexlansoprazole improves quality of life for gastrosophageal reflux disease patients
Monday, February 27, 2012

AAP Recommends HPV Vaccine for Boys, Too
Follows guidance provided by the U.S. Centers for Disease Control and Prevention
Monday, February 27, 2012

ASD Meds More Commonly Used by Teens With Comorbid ADHD
Teenagers with autism more likely to use psychotropic medication if they also have ADHD
Friday, February 24, 2012

UVB Preferred for Treatment of Moderate to Severe Psoriasis
Dermatologist treatment preferences vary by geographical region
Friday, February 24, 2012

Variable Mortality Risk for Antipsychotic Use in Elderly
Effect strongest soon after start of treatment; dose-response relationship for most drugs
Friday, February 24, 2012

Model Predicts Death Due to Acetaminophen Overdose
Mathematical model estimates overdose amount, time elapsed; predicts outcome in acute liver failure
Friday, February 24, 2012

Aspirin and Clopidogrel Improve Claudication Distance
Similar improvement in patients with intermittent claudication due to peripheral arterial disease
Thursday, February 23, 2012

Bisphosphonate Use Linked to Reduced Colorectal Cancer Risk
On analysis of specific bisphosphonates, effect significant only for risedronic acid
Thursday, February 23, 2012

Pharmacist-Led Intervention Reduces Medical Errors
Intervention includes feedback, educational outreach, dedicated support and is cost-effective
Tuesday, February 21, 2012

Nicotine Replacement Therapy Linked With Infantile Colic
Women who smoke, use NRT, or both have increased risk of infantile colic in their offspring
Monday, February 20, 2012

Donepezil Improves Symptoms in Dementia With Lewy Bodies
Significant cognitive, behavioral, and global improvements seen at 5 or 10 mg/day donepezil
Friday, February 17, 2012

Smoking Cessation Drug May Also Reduce Drinking
Varenicline increases alcohol's aversive effects, including dysphoria and nausea
Friday, February 17, 2012

Overdose Prevention Programs Using Opioid Antagonist
Naloxone use, however, not sufficient to address high overdose death rates
Thursday, February 16, 2012

Smoking Bans Lead to Less, Not More, Smoking at Home
In countries with smoke-free legislation, rate of home smoking has decreased, not increased
Thursday, February 16, 2012

Intramuscular Midazolam As Safe As Intravenous Lorazepam
Safe, effective for treatment of seizures when administered by paramedics en route to hospital
Wednesday, February 15, 2012

Semuloparin Prophylaxis Effective in Cancer Patients
Reduces incidence of thromboembolic events during chemo, with no increase in major bleeding
Wednesday, February 15, 2012

Topical Corticosteroids Impair Restoration of Skin Barrier
Corticosteroids OK for acute atopic dermatitis, but calcineurin inhibitors better for long-term treatment
Wednesday, February 15, 2012

New Data Published on Safety of Leflunomide in Pregnancy
Data provide some reassurance to women exposed to leflunomide before or during pregnancy
Wednesday, February 15, 2012

Vitamin D Doesn't Improve Cardiac Measures in CKD Patients
No improvements in left ventricular mass, measures of diastolic dysfunction with paricalcitol therapy
Wednesday, February 15, 2012

Hemoglobin A1c, Fasting Plasma Glucose Relationship Studied
Oral therapies impact relationship; should be considered when interpreting A1C levels
Wednesday, February 15, 2012

Study Finds Antibiotic for Acute Rhinosinusitis Is Not Helpful
After three days, no significant symptom difference between treatment with amoxicillin and placebo
Tuesday, February 14, 2012

Supplements Don't Prevent Cancer in Cardiac Patients
Dietary supplements of B vitamins, folate, omega-3 not linked to improved cancer outcomes
Tuesday, February 14, 2012

Patient Satisfaction Linked to Varied Health Care Utilization
Satisfaction linked to lower emergency department use but increased admissions, mortality, costs
Tuesday, February 14, 2012

Zioptan Eyedrops Approved for Glaucoma, Ocular Hypertension
Product should not be used by children or by pregnant women
Monday, February 13, 2012

Guidelines for VTE Prophylaxis in Nonsurgical Patients Issued
Guidelines apply to acute and critical patients, outpatients with cancer, long-distance travelers
Thursday, February 09, 2012

Intracerebroventricular Opioid Infusion Feasible at Home
Effective for treatment of refractory pain in terminal patients; low incidence of adverse events
Thursday, February 09, 2012

Testosterone Patches Improve Low Sexual Desire Disorder
Transdermal testosterone patches relieve symptoms in postmenopausal women
Thursday, February 09, 2012

Fen-Phen Derivative Likely Caused >1,000 Deaths in France
From 1976 to 2009, drug may have contributed to approximately 3,100 hospitalizations, 1,300 deaths
Thursday, February 09, 2012

Prescription Shampoo Approved to Treat Head Lice
Sklice is sanctioned for children as young as 6 months
Wednesday, February 08, 2012

Cefpodoxime Not Recommended for Acute, Uncomplicated Cystitis
Cefpodoxime found inferior to ciprofloxacin in achieving clinical cure
Tuesday, February 07, 2012

New Guidelines Recommend Metformin in Type 2 Diabetes
Monotherapy recommended if lifestyle change inadequate; add second agent if necessary
Tuesday, February 07, 2012

Three 'Targeted' Cancer Drugs Up Risk of Fatal Adverse Events
No differences found in rates of fatal adverse events between VEGFR TKIs or by tumor types
Tuesday, February 07, 2012

Breast Cancer Prevention Drug Linked to Bone Loss
Exemestane increases bone loss despite calcium and vitamin D supplementation
Tuesday, February 07, 2012

Fluoxetine, Venlafaxine Tied to Drop in Adult Suicide Behaviors
For youth, no difference in suicide thoughts or behavior with antidepressant treatment
Monday, February 06, 2012

Mechanism for Metabolic Effects of Resveratrol Elucidated
Resveratrol inhibits phosphodiesterase 4 in mice, resulting in indirect activation of s irtuin 1
Monday, February 06, 2012

Noroviruses Are Leading Cause of Hospital Infections
Particularly in nonacute care setting; often leading to unit closure
Monday, February 06, 2012

RA Drug Trial Funding Source Not Linked to Outcome
Positive outcomes are not more likely in industry-funded rheumatoid arthritis drug trials
Monday, February 06, 2012

Direct to Consumer Statin Web Sites of Poor Quality
Internet sites are prevalent, but information on safe use and side effects flawed
Thursday, February 02, 2012

Ghrelin Stimulates Food Intake During Cisplatin-Based Chemo
Also minimizes adverse effects related to anorexia and nausea for esophageal cancer patients
Thursday, February 02, 2012

AHA: Apixaban Beats Aspirin for Stroke Prevention in A-Fib
More effective for patients with a-fib, prior stroke history, unsuitability for vitamin K antagonists
Thursday, February 02, 2012

Occasional Hard Drug Use in Mid-Life Hikes Mortality Risks
Trajectory analysis shows significantly increased risk for early frequent/later occasional users
Thursday, February 02, 2012

No Improvement in C-Peptide Levels With GAD-Alum
GAD-alum and placebo produce similar C-peptide decreases in children with type 1 diabetes
Wednesday, February 01, 2012

Oral Ulipristal Acetate Controls Uterine Fibroid Bleeding
Two studies show efficacy of oral ulipristal acetate compared with placebo, leuprolide acetate
Wednesday, February 01, 2012

AAP: Childhood Vaccination Schedules Approved for 2012
Three schedules and accompanying footnotes offer new clarifications and guidance
Wednesday, February 01, 2012

Proton Pump Inhibitor Use Ups Hip Fracture Risk for Women
More than 50 percent increased risk for postmenopausal current or former smokers
Wednesday, February 01, 2012

Fenofibrate Found Safe in Diabetes With Renal Impairment
Reduced total cardiovascular events in patients with type 2 diabetes and moderate renal impairment
Tuesday, January 31, 2012

Diabetes Drugs Affect Pancreatic Cancer Risk
Metformin linked to lower risk in women; sulfonylureas, insulin associated with higher risk
Tuesday, January 31, 2012

Erivedge Approved to Treat Basal Cell Carinoma
The most common skin cancer
Monday, January 30, 2012

Meta-Analysis: Statin Therapy Equally Effective in Women, Men
Statins significantly decrease cardiovascular events, all-cause mortality in both sexes
Monday, January 30, 2012

Antiretroviral Medications Linked to Cleft Deformities
Drugs to keep HIV-infected women from transmitting virus to fetus may trigger cleft defects
Monday, January 30, 2012

More Research Needed on Weaning of Addicted Infants
Nurseries need a plan for the evaluation, treatment of infants at risk for or showing withdrawal
Monday, January 30, 2012

Bydureon Approved for Type 2 Diabetes
A once-weekly injection
Friday, January 27, 2012

No Complications From Using Stored Red Blood Cells
Short-term complication status similar in fresh versus standard issue red blood cell transfusions
Friday, January 27, 2012

Comparable Clinical Activity for Low-, High-Dose Clofarabine
More adverse effects seen for high dose in patients with higher-risk myelodysplastic syndrome
Friday, January 27, 2012

ACE Inhibitors Not Linked to Improved Outcomes After ACS
Prior use of ACE inhibitors does not improve in-hospital outcomes after acute coronary syndrome
Thursday, January 26, 2012

Survival Reduced for Patients With Cancer Who Have Diabetes
Type of cancer and diabetes treatment influence survival
Thursday, January 26, 2012

Positive Affirmation Improves Medication Adherence
But, does not significantly reduce blood pressure in African-Americans with hypertension
Thursday, January 26, 2012

Sildenafil Shows Potential for Lymphatic Malformations
Regression of congenital vascular anomalies seen in three children treated with oral sildenafil
Wednesday, January 25, 2012

Oxaliplatin Improves Survival for Colorectal Cancer Patients
Improvements found in community settings, even amongst older and minority populations
Wednesday, January 25, 2012

Lansoprazole Does Not Improve Asthma Control in Children
Treatment with lansoprazole associated with increased number of respiratory infections
Tuesday, January 24, 2012

Unemployed Have Poorer Mental and Physical Health
And are less likely to receive needed medical care and prescriptions
Tuesday, January 24, 2012

Anastrozole Sequence Doesn't Significantly Improve Survival
Sequencing tamoxifen and anastrozole provides limited improvement in breast cancer outcome
Tuesday, January 24, 2012

Dutasteride Delays Low-Risk Prostate Cancer Progression
Men under active surveillance for low-risk prostate cancer benefit from adjunct dutasteride
Tuesday, January 24, 2012

HealthGrades IDs Notable Hospitals for Clinical Excellence
If all hospitals performed at this level, thousands of Medicare deaths, complications could be averted
Tuesday, January 24, 2012

Statins May Reduce Risk for HCC in Hep B-Infected Patients
Hepatocellular cancer risk reduced in a dose-dependent manner in hepatitis B-infected patients
Monday, January 23, 2012

Dosing Errors Occur With IV Acetaminophen in Children
Ten-fold overdose may occur in young children; treatment with acetylcysteine may be indicated
Monday, January 23, 2012

Inadequate Hep B Vaccinations for High-Risk Adults
More than half the adults at high risk of infection miss opportunities for vaccinations
Monday, January 23, 2012

Mild-to-Moderate Asthma Frequently Non-Eosinophilic
Nearly half of patients with mild-to-moderate asthma have non-eosinophilic phenotype
Monday, January 23, 2012

Neuromodulators Reduce Pain in Rheumatoid Arthritis
Second study shows no beneficial effect of muscle relaxants on pain in rheumatoid arthritis
Friday, January 20, 2012

Warfarin Patients With Head Trauma Need Second CT Scan
For patients on warfarin, 24-hour observation and repeat CT scan detects delayed bleeding
Friday, January 20, 2012

Taking Two or More Medications Increases Fall Rate
For young and middle-aged adults, taking two or more meds tied to 2.5-fold increase in fall risk
Friday, January 20, 2012

No Autoimmune Safety Signal for Quadrivalent HPV Vaccine
Women vaccinated with HPV4 have no increase in incidence of 16 autoimmune disorders
Friday, January 20, 2012

Design Flaws Cast Doubt on Million Woman Study
Evidence review suggests that study findings do not adequately satisfy principle of causation
Thursday, January 19, 2012

Contraceptives Eschewed by Half of Teenage Mothers
And many use the lesser effective birth control methods to prevent pregnancy
Thursday, January 19, 2012

Chronic Hepatitis C May Benefit From New Antivirals
Phase 2a study indicates virologic response with daclatasvir, asunaprevir treatment
Thursday, January 19, 2012

Bevacizumab Combo Improves Colorectal Cancer Survival
Survival benefits greater with irinotecan-based chemo; but more adverse effects with bevacizumab
Wednesday, January 18, 2012

Circulating Tumor Cells Predict Small-Cell Lung CA Prognosis
Both baseline number and change in CTC following first cycle of chemotherapy prognostic
Wednesday, January 18, 2012

Meningitis B Vaccine Immunogenic in Adolescents
Two doses of four-component Neisseria meningitidis serogroup B vaccine immunogenic
Wednesday, January 18, 2012

Peds Liver Transplant Patients Tolerate Drug Withdrawal
For pediatric living donor liver transplant recipients, immunosuppression withdrawal possible
Wednesday, January 18, 2012

Dual Inhibition of HER2 Beats Single Agent in Breast Cancer
For HER2-positive breast cancer, inhibition with lapatinib and trastuzumab superior to single agent
Tuesday, January 17, 2012

Vitamin D Supplements Do Not Reduce COPD Exacerbations
But, supplementation may benefit COPD patients with severe vitamin D deficiency
Monday, January 16, 2012

Maternal Asthma Meds Not Linked to Most Birth Defects
Few defects positively associated with maternal asthma medication use during early pregnancy
Monday, January 16, 2012

Young Women Often Perceive Their Weight Gain Inaccurately
Race/ethnicity, contraception impact perception, which is frequently inaccurate in young women
Friday, January 13, 2012

Thromboprophylaxis Rate Low for Knee Arthroplasty in Taiwan
Prophylaxis rate of 2.2 percent may be related to low incidence of post-op venous thromboembolism
Friday, January 13, 2012

U.S. Health Care Expenditure Still Unevenly Distributed
In 2008 and 2009, 1 percent of population account for ~20 percent of spending
Friday, January 13, 2012

Maternal Antidepressants Up Infant Pulmonary Hypertension
Similar risk found across the selective serotonin reuptake inhibitor class of antidepressants
Friday, January 13, 2012

Novel Anticancer Agents ID'd From NIH Drug Collection
Quantitative high-throughput drug screening method identifies novel anticancer drug candidates
Thursday, January 12, 2012

Rx Provides Fast Relief of Pain, Urgency of Interstitial Cystitis
Study finds alkalinized lidocaine plus heparin provides 12 hours of relief of pain and urgency
Wednesday, January 11, 2012

Single Oral Azithromycin Dose Effective for Yaws
Oral azithromycin non-inferior to standard benzathine benzylpenicillin for treatment of yaws
Wednesday, January 11, 2012

GLP-1R Agonists Found Effective for Weight Loss
Glucagon-like peptide-1 receptor agonists also reduce blood pressure and total cholesterol
Wednesday, January 11, 2012

Occasional Marijuana Use Not Tied to Adverse Lung Function
Nonlinear association for marijuana exposure and lung function; no adverse effects for low exposure
Tuesday, January 10, 2012

Transdermal Nicotine May Benefit Cognitive Impairment
Cognitive test improvement, but no significant change in clinical global impression
Tuesday, January 10, 2012

Losartan Halts Smoke-Related Lung Damage in Mice
Inhibition of TGF-β normalizes smoke-induced TFG-β signaling and prevents alveolar cell death
Tuesday, January 10, 2012

No Rise in Intussusception After Rotavirus Shot Revival
No increase seen in intussusception discharges since 2006 reintroduction of rotavirus vaccine
Tuesday, January 10, 2012

Benefit of Aspirin in Primary Prevention Questioned
Despite reduction in nonfatal MIs, no reduction seen in cardiovascular death or cancer mortality
Tuesday, January 10, 2012

Nicotine Replacement Therapy Doesn't Avert Smoking Relapse
Likelihood of relapse unaffected by nicotine replacement therapy, with or without counseling
Tuesday, January 10, 2012

Memantine Has No Impact on Cognition in Down's Syndrome
Adults older than 40 with Down's syndrome do not benefit from treatment with memantine
Tuesday, January 10, 2012

Long-Term Prognostic Value of Dobutamine Stress Echo Limited
Long-term predictive value restricted for patients with diabetes unable to take an exercise stress test
Tuesday, January 10, 2012

Statins Increase Diabetes Risk for Postmenopausal Women
Association significant even after adjusting for variables; seen for all types of statins
Monday, January 09, 2012

Acupuncture May Have Minor Effect in Migraine Prevention
Compared with sham treatment, significant reduction in days with migraine at 13 to 16 weeks
Monday, January 09, 2012

Rilonacept Reduces Gout Flares During Acute Urate Lowering Rx
Phase 2 trial shows that rilonacept reduces gout flares during initiation of allopurinol therapy
Monday, January 09, 2012

Hypoglycemia in Intensive Diabetes Control May Up Survival
Inverse relationship seen between number of hypoglycemic episodes and risk of death
Friday, January 06, 2012

HCV Antivirals Cost-Effective for Injecting Drug Users
Model shows antiviral treatment cost-effective when baseline prevalence is less than 60 percent
Friday, January 06, 2012

Frequent Aspirin Use Linked to Aging Macula Disorder
For daily aspirin users, likelihood of disorder increases with increasing severity of AMD
Friday, January 06, 2012

Shedding Persists in Herpes Even With High-Dose Antivirals
Reactivation likely accounts for transmission during therapy; new treatments needed
Thursday, January 05, 2012

HPV Vaccine Doesn't Lull Girls Into Complacency About Sex
Mom, daughter vaccine knowledge, communication tied to ongoing perception of need for safer sex
Thursday, January 05, 2012

Epilepsy, HIV Drug Combination Therapies Require Caution
Coadministration of antiepileptic drugs and antiretrovirals may necessitate dose adjustment
Thursday, January 05, 2012

Montelukast Doesn't Cut Upper Respiratory Infection Incidence
For preschool children, 12-week prophylactic treatment doesn't reduce incidence of URI
Wednesday, January 04, 2012

Metformin Hikes B12 Deficiency in Type 2 Diabetes
OTC supplements fail to correct B12 deficiencies in type 2 diabetes, regardless of metformin therapy
Thursday, December 29, 2011

Oseltamivir-Resistant H1N1 Identified in Australia
Between May and August 2011, resistant viruses with H275Y substitution ID'd in 29 of 182 patients
Thursday, December 29, 2011

Enoxaparin Doesn't Reduce Death Rate for Acutely Ill
Death from any cause at 30 days and rates of major bleeding similar with enoxaparin, placebo
Wednesday, December 28, 2011

Bevacizumab Ups Progression-Free Survival in Ovarian Cancer
Two studies demonstrate the benefit of bevacizumab added to standard therapy
Wednesday, December 28, 2011

Study Compares Onset of Action of Two Types of Botulinum Toxin
AbobotulinumtoxinA yields more significant improvements in crow's feet at day 4
Monday, December 26, 2011

Extended Nevirapine Reduces Breastfeeding HIV Transmission
Results in 54 percent reduction in mother-to-child HIV transmission during breastfeeding
Friday, December 23, 2011

Correcting Anemia Reduces Odds of Renal Transplant Failure
Complete anemia correction reduces progression to chronic allograft nephropathy post-transplant
Thursday, December 22, 2011

Postmenopausal HRT Improves Sexual Function
HRT, dehydroepiandrosterone, tibolone all improve quality of sexual function and frequency
Thursday, December 22, 2011

Isentress Approval Expanded to Include Children and Teens
HIV drug expanded to include children and adolescents ages 2 to 18
Wednesday, December 21, 2011

Cixutumumab Tolerated for Pediatric Refractory Solid Tumors
Recommended phase II pediatric dose is 9 mg/kg intravenously once per week
Wednesday, December 21, 2011

Aflibercept Shows Clinical Activity for Malignant Ascites
Ups time to paracentesis in advanced chemo-resistant ovarian cancer with recurrent ascites
Wednesday, December 21, 2011

NCHS: Poisonings Are Leading Cause of Injury Deaths
In 2008, poisoning deaths were main cause of injury death, with almost 90 percent due to drugs
Wednesday, December 21, 2011

Vitamin D, Calcium Found to Cut Fracture, Cancer Risk
A second study offers no evidence that vitamin D supplementation prevents cardiovascular disease
Tuesday, December 20, 2011

Little Risk to Offspring From Maternal Inhaled Steroids
But may be associated with increased risk of endocrine/metabolic disorders
Tuesday, December 20, 2011

Combo Therapies in Psoriasis More Effective Than Monotherapy
Adding phototherapy to topical monotherapy improves psoriasis clearance
Monday, December 19, 2011

Ovarian Failure Risk Differs with Chemo Type in Hodgkin's
Significant risk from alkylating chemo; little risk from nonalkylating for those less than age 32
Monday, December 19, 2011

Laws Impact School Support for Anaphylaxis Management
Gaps exist in awareness of anaphylaxis procedure and EpiPen administration technique
Monday, December 19, 2011

Omega-3 Index Not Linked to Bleeding in Acute MI
No link between red blood cell omega-3 fatty acid index and serious or mild to moderate bleeding
Monday, December 19, 2011

Suboptimal Intensive Statin Therapy Use After ACS
Poor persistence after discharge for newly initiated IST after acute coronary syndrome
Monday, December 19, 2011

Vaginal Progesterone Cuts Preterm Birth, Neonatal Deaths
Reduces preterm birth, neonatal morbidity and mortality in asymptomatic women with short cervix
Friday, December 16, 2011

High-Dose Aspirin Impacts Fibrin Network in Diabetes
Aspirin at 320 mg increases fibrin network permeability in patients with type 1 diabetes
Friday, December 16, 2011

Adjuvant Bevacizumab Feasible for Nasopharyngeal Cancer
Adjuvant treatment is not associated with grade 3 to 4 hemorrhages or grade 5 adverse events
Friday, December 16, 2011

Chemotherapy Options ID'd for Cisplatin-Unfit Urothelial Cancer
Carboplatin-based regimens with gemcitabine or methotrexate/vinblastine show similar efficacy
Thursday, December 15, 2011

Statins Lower Death Risk in Adults Hospitalized With Flu
Statins given before or during hospitalization reduce mortality in adults with influenza
Thursday, December 15, 2011

ASH: Most Cancer-Related Clots Occur in Outpatients
Of the venous thromboembolism cases in patients with cancer, 78.3 percent occur in outpatients
Tuesday, December 13, 2011

No Increase in Birth Defects for Offspring of Cancer Survivors
Parental childhood exposure to chemo, radiation not tied to congenital anomalies in offspring
Tuesday, December 13, 2011

Khat Ups Adverse Outcomes in Acute Coronary Syndrome
Khat chewers with acute coronary syndrome have increased risk of death, cardiovascular events
Monday, December 12, 2011

ADHD Med Use Not Tied to Increased Cardiovascular Risk
Current, new ADHD medication users do not have higher risk of MI, sudden cardiac death, stroke
Monday, December 12, 2011

ASH: Aspirin Safe and Effective for Preventing VTE Recurrence
After first unprovoked VTE, long-term aspirin after standard anticoagulant therapy decreases recurrence
Monday, December 12, 2011

Chemo, Radiation Worsen Cognition in Breast CA Survivors
However, hormonal therapy does not predict changes in cognitive functioning over time
Monday, December 12, 2011

ASH: Gene Therapy Shows Promise for Hemophilia B
Administration of virus vector expressing factor IX transgene prevents spontaneous bleeding
Monday, December 12, 2011

ASH: Hydroxyurea Safe, Effective in Pediatric Sickle Cell
And, two-year treatment of young children with hydroxyurea is not associated with genotoxicity
Monday, December 12, 2011

SABCS: Adjuvant Bevacizumab Ups Progression-Free Survival
Statistically significant improvement seen in Independent Review Committee assessment
Thursday, December 08, 2011

SABCS: Breast Cancer Survival Up With Everolimus + Exemestane
And, improved progression-free survival with add-on pertuzumab in HER2+ metastatic cancer
Thursday, December 08, 2011

Rifapentine Plus Isoniazid Noninferior to Isoniazid Alone
Higher completion rate with three months of combo therapy versus nine months of isoniazid
Wednesday, December 07, 2011

Intranasal Vaccine Effective Against Norwalk Virus Illness
Two doses of norovirus virus-like particle vaccine protects against gastroenteritis, infection
Wednesday, December 07, 2011

SABCS: Long-Term Benefits for Zoledronic Acid in Breast Cancer
And, for postmenopausal women, immediate ZOL therapy reduces risk of disease-free survival events
Wednesday, December 07, 2011

Role of Environmental Factors in Breast Cancer Explored
IOM finds consistent evidence for links with combo HRT, postmenopausal weight gain, radiation, alcohol
Wednesday, December 07, 2011

SABCS: Dyslipidemia, Obesity After 60 Tied to Breast CA Risk
Diabetes, obesity after age 60, abnormally low lipid levels linked to increased breast cancer risk
Wednesday, December 07, 2011

Spending on Depression Up From 1996 to 2005
Increased Florida Medicaid spending but minimal improvements in quality of care
Wednesday, December 07, 2011

Bisphosphonate Use Ups Knee, Hip Implant Survival
Almost two-fold increase seen in implant survival time after total knee or hip arthroplasty
Wednesday, December 07, 2011

Androgen Deprivation in Prostate Cancer Not Tied to CVD Death
But, ADT is associated with reduced risk of prostate cancer-specific mortality, all-cause death
Tuesday, December 06, 2011

FDA and FTC Crack Down on Homeopathic Weight Loss Drug
Marketers of off-label HCG issued warning letters
Tuesday, December 06, 2011

Preventive Asthma Medication Use Increasing in Children
Lower use reported among minority children, adolescents, and uninsured
Tuesday, December 06, 2011

Eating Little or No Fish Ups Young Women's CVD Risk
Women who never eat fish have three-fold higher disease risk than those who eat fish every week
Monday, December 05, 2011

Medical Students Fail to ID Hand Hygiene Indications
Preclinical phase medical students lack knowledge about hand disinfection indications
Monday, December 05, 2011

Similar Efficacy Among Second-Generation Antidepressants
But different onset of action and adverse events in adults with major depressive disorder
Monday, December 05, 2011

Fluoxetine Improves Repetitive Behaviors in Adult ASDs
Improvement in Yale Brown Obsessive Compulsive subscale, Clinical Global Impression scale
Monday, December 05, 2011

AES: Prenatal Valproate Exposure Tied to Autism Risk
More than double risk of autism spectrum disorder; more than four-fold risk of childhood autism
Monday, December 05, 2011

Youth Often Get Hypertension Rx From PCPs Who Treat Adults
Whites, older adolescents, and those with comorbidity more likely to receive prescription
Monday, December 05, 2011

Belimumab + Standard Therapy Efficacious for Lupus
Combo improves Systemic Lupus Erythematosus Responder Index response rate
Monday, December 05, 2011

Green Tea Polyphenol Inhibits HCV Entry Into Hepatocytes
Epigallocatechin-3-gallate blocks infection of cells by extracellular virions, cell-to-cell spread
Monday, December 05, 2011

Cold Sore Susceptibility Linked to SNPs on C21orf91
Association seen in linkage analysis, parental transmission disequilibrium testing
Friday, December 02, 2011

Salvianolic Acid B Suppress Maturation of Dendritic Cells
Sal B effects on human monocyte-derived dendritic cell maturation blocked by PPARγ siRNA
Friday, December 02, 2011

First Generic Lipitor Approved
Widely used statin drug helps lower bad cholesterol
Thursday, December 01, 2011

Diet High in Antioxidants Cuts Stroke Risk for Women
Reduction in total stroke for those without prior CVD; hemorrhagic stroke for those with history
Thursday, December 01, 2011

Anticoagulant Self-Monitoring Safe Option for Suitable Patients
Self-monitoring, self-management associated with significant reduction in thromboembolic events
Thursday, December 01, 2011

Parental CA Therapy Not Tied to Genetic Defects in Offspring
Neither parental chemo nor preconception gonad irradiation linked to genetic defects in children
Thursday, December 01, 2011

Learning Assessment Tool IDs R.N. Educational Needs
Pediatric procedural sedation education needs identified through questionnaire
Thursday, December 01, 2011

MK-0941 Safe, Efficacious for Short-Term Glucose Control
Improvements in A1C, two-hour postmeal glucose seen at week 14 were not sustained by week 30
Thursday, December 01, 2011

IL-2 Tied to Regulatory T-Cell Expansion in Graft-Versus-Host
And, IL-2 associated with Treg recovery and clinical improvement in HCV-induced vasculitis
Wednesday, November 30, 2011

Delayed Acyclovir in Neonates With Herpes Ups Mortality
With overall in-hospital mortality rate of 7.3 percent for neonates with herpes simplex infection
Wednesday, November 30, 2011

Intensified Immunochemotherapy Benefits B-Cell Lymphoma
Intensified immunochemotherapy ups overall, event, progression-free survival in large B-cell lymphoma
Tuesday, November 29, 2011

Concomitant MMRV With PCV-7 Highly Immunogenic, Safe
Measles, mumps, rubella, varicella vaccine co-administered with pneumococcal vaccine safe
Tuesday, November 29, 2011

NSAID, Statin Use Cuts Cancer Risk in Barrett's Esophagus
NSAIDs, statins each reduce neoplastic progression risk; additive benefit with combined use
Tuesday, November 29, 2011

Opioid Rx for Chronic Abdominal Pain Up Over Last Decade
Most commonly prescribed to 25- to 40-year-olds; least commonly to uninsured, African-Americans
Tuesday, November 29, 2011

High-Performing Docs Learn Equally From Success, Failure
High performers learn from successes, failures; low performers have asymmetric learning rates
Monday, November 28, 2011

Chronic Disease Management Ups Smoking Abstinence
And, nicotine therapy during practice quit attempt linked to increased incidence of quit attempts
Monday, November 28, 2011

Many Pediatricians OK With Alternative Vaccine Schedules
Pediatricians least willing to consider ACIS for H. influenza type b, DTaP, pneumococcal conjugate
Monday, November 28, 2011

GIP Identified As Bifunctional Blood Glucose Stabilizer
Glucose-dependent insulinotropic polypeptide infusion affects glucagon levels, insulin release
Monday, November 28, 2011

Everolimus Ups Survival in Carcinoid Syndrome
For patients with advanced neuroendocrine tumors, octreotide LAR + everolimus improves PFS
Monday, November 28, 2011

Afternoon Shots Up Post-Immunization Sleep Duration
Prophylactic acetaminophen not significant predictor of post-shot sleep duration
Monday, November 28, 2011

Drugs ID'd in Most Older Adult Emergency Hospitalizations
Warfarin, insulin, oral antiplatelets, hypoglycemics implicated in most emergency hospitalizations
Wednesday, November 23, 2011

Similar Asthma Outcomes With Daily, Intermittent Budesonide
But, daily regimen leads to greater budesonide exposure than intermittent regimen in children
Wednesday, November 23, 2011

Dabigatran Poses Challenge in Treating Injured Patients
Due to lack of readily available methods to assess degree of anticoagulation, and reverse effects
Wednesday, November 23, 2011

Staggered Acetaminophen Overdose Tied to Poor Outcome
Delayed presentation after overdose associated with death/liver transplantation
Wednesday, November 23, 2011

Prolonged LDL-Lowering Statin Treatment Beneficial, Safe
Benefits persist without increase in mortality, morbidity for at least five years after treatment
Wednesday, November 23, 2011

Alendronate Ups BMD in Patients Taking Steroids for Skin Diseases
Bone mineral density increased at lumbar spine, femoral neck in immunobullous disorders
Wednesday, November 23, 2011

Continuous Glucose Monitoring Improves Glycemic Control
Real-time monitoring gives patients with type 2 diabetes not on prandial insulin sustained control
Wednesday, November 23, 2011

Adjuvant Capecitabine Does Not Improve Breast Cancer Survival
Adding capecitabine to docetaxel, epirubicin, cyclophosphamide doesn't up survival
Wednesday, November 23, 2011

Breast CA, Tenderness Linked in Women on Combo HRT
CEE + MPA doubles the risk of breast cancer in women with baseline breast tenderness
Tuesday, November 22, 2011

Process Attributes Most Impact Psoriasis Therapy Choice
Treatment location, probability of benefit, delivery method affects patients' treatment preference
Tuesday, November 22, 2011

Oral Antibiotic Use in Acne Tied to Reported Pharyngitis
Odds of reporting pharyngitis more than three times higher for patients taking oral antibiotics
Monday, November 21, 2011

Nonpunitive Method Improves Medical Error Reporting
Most common errors: misfiled or incorrectly entered patient info
Monday, November 21, 2011

Grape Seed Extract Lowers Squamous Cell Carcinoma Risk
Use of multivitamins is linked to borderline significant reduction in the risk of SCC
Monday, November 21, 2011

Post-Bat Exposure Prophylaxis Up in New York
Increased numbers of bats submitted for rabies testing, reports of exposure, and use of PEP
Friday, November 18, 2011

Minoxidil Foam Is Effective in Androgenic Alopecia
Once-daily 5 percent MTF is as effective as twice-daily 2 percent topical solution
Friday, November 18, 2011

Growth Hormone Replacement Ups Diabetes Incidence
Higher plasma glucose, HbA1c in adult patients with growth hormone deficiency
Friday, November 18, 2011

Rapid Safety Monitoring of H1N1 Vaccine Feasible
Uses modern technology to collect rapid self-reported safety data in large numbers of patients
Friday, November 18, 2011

Long-Term Antiepileptic Drug Therapy Ups Atherosclerosis
Carbamazepine, phenytoin, valproic acid, but not lamotrigine alter markers of vascular risk
Friday, November 18, 2011

Hib Vaccine Has Cut H. influenzae Incidence Dramatically
Burden of disease is highest in youngest and oldest age groups
Thursday, November 17, 2011

Tamoxifen Discontinuation Rate High in Male Breast Cancer
Majority of patients experience one or more toxic effect during tamoxifen treatment
Thursday, November 17, 2011

AHA: CYP2C19*2 Carriers Need Triple Clopidogrel Dosing
Similar platelet reactivity with 225 mg in CYP2C19*2 heterozygotes, 75 mg in noncarriers
Wednesday, November 16, 2011

Mycophenolate Mofetil Beats Azathioprine in Lupus Nephritis
With superior maintenance of renal response to treatment, and superior prevention of relapse
Wednesday, November 16, 2011

AHA: Drug-Eluting Balloons Promising Alternative to Stents
And, PCI with drug-eluting balloons also feasible in patients at risk of bleeding complications
Wednesday, November 16, 2011

Breast Cancer Survivors Have Impaired Neurological Function
Additional reductions in prefrontal function, decreased executive function post-chemo
Wednesday, November 16, 2011

Denosumab Improves Bone-Metastasis-Free Survival
Delays time to first bone mets for patients with high-risk castration-resistant prostate cancer
Wednesday, November 16, 2011

U.S. Oncologists Rate Selves Highly in Pain Management
But, acknowledge barriers to optimal care, and consider quality of training to be poor
Tuesday, November 15, 2011

AHA: Adding Niacin Doesn't Beat Statin Alone for CV Risk
Although addition of niacin increases HDL cholesterol, lowers triglyceride and LDL cholesterol levels
Tuesday, November 15, 2011

AHA: Evacetrapib Alone/With Statins Useful in Dyslipidemia
Significantly increases HDL cholesterol and reduces LDL cholesterol compared to statins alone
Tuesday, November 15, 2011

Global Oral Contraceptive Use Tied to Prostate Cancer Incidence
Ecological study shows oral contraceptive use linked to prostate cancer incidence, death worldwide
Tuesday, November 15, 2011

U.S. Teen Vaccination Coverage Up From 2006 to 2009
Could be bettered via simultaneous administration, provider endorsement, parental awareness
Monday, November 14, 2011

Delayed Acyclovir Ups Hospital Stay for Eczema Herpeticum
One day delay in starting acylovir ups hospital stay by 11 percent in pediatric eczema herpeticum
Monday, November 14, 2011

AHA: Dronedarone Detrimental for Certain A-Fib Patients
Counter to hypothesis, agent may cause major vascular events
Monday, November 14, 2011

Copayment Elimination Ups Post-MI Medication Adherence
Enhanced coverage also decreases patient spending without increasing overall health costs
Monday, November 14, 2011

Rivaroxaban Improves Acute Coronary Syndrome Outcomes
Apixaban thromboprophylaxis better than enoxaparin; adjuvant vorapaxar not effective/safe
Monday, November 14, 2011

AHA: Cardiac Stem Cells Show Promise in Heart Failure
Promising phase 1 trial results on their safety, efficacy in post-MI heart failure
Monday, November 14, 2011

SfN: Exercise Tied to Neuronal Changes in Fibromyalgia
Increased pain sensation following medication withdrawal is improved by aerobic exercise
Monday, November 14, 2011

AHA: Single AMG145 Dose Lowers LDL-Cholesterol Levels
AMG145 lowers LDL-C, total cholesterol, apo-B, but has no effect on triglycerides, HDL-C, apo-A1
Monday, November 14, 2011

Diazoxide Lowers Glucose Production in Humans, Rats
Hypothalamic K_ATP channels involved in regulation of endogenous glucose production
Friday, November 11, 2011

Methamphetamine Linked to Increased Schizophrenia Risk
Increased risk with methamphetamine-use disorder; similar to risk for cannabis-use disorder
Friday, November 11, 2011

About 15,000 Intentional Poisoning ER Visits in 2009
Alcohol and drug combinations involved in 60 percent of these emergency department visits
Friday, November 11, 2011

Estimated Flu Incidence of 90 Million for 2008 in Under-5s
Nearly all flu-associated acute lower respiratory infection deaths occur in developing countries
Friday, November 11, 2011

Community-Based Treatment Improves Pneumonia Outcomes
Community case management reduces treatment failure rate in children compared to standard care
Friday, November 11, 2011

Zostavax Still Recommended Only for Those 60 and Over
Supply and data issues influence committee decision
Thursday, November 10, 2011

Glove Use Linked to Reduced Hand Hygiene Compliance
Gloves often worn when not indicated, and not worn when indicated
Thursday, November 10, 2011

Pre-Knee Replacement Use of Opioids Tied to Complications
Significantly higher complication rate and greater need for pain management referral
Thursday, November 10, 2011

Evidence Shows Reduced Sodium Intake Lowers BP
But increase seen in levels of renin, aldosterone, adrenaline, noradrenaline, cholesterol, lipids
Thursday, November 10, 2011

Epigenetic Therapy Shows Promise in Progressive NSCLC
Demethylation of epigenetically silenced genes associated with lung cancer seen in blood samples
Thursday, November 10, 2011

Alcoholic Hepatitis Combo Meds Don't Help Six-Month Survival
But early liver transplant improves survival in medically unresponsive severe alcoholic hepatitis
Wednesday, November 09, 2011

Trilipix Not Found to Reduce Risk of Coronary Events
FDA advises physicians to counsel patients on risks and benefits
Wednesday, November 09, 2011

Wait-and-See Policy Feasible for Some With Rectal Cancer
Using strict selection criteria and follow-up, wait-and-see results in promising outcomes
Wednesday, November 09, 2011

TNF-α Antagonists Do Not Up Infection Hospitalizations
In autoimmune disease, infection hospitalization risk similar to that with nonbiologic medication
Wednesday, November 09, 2011

HPV-16/18 Efficacious Against CIN3+, Adenocarcinoma in Situ
And, vaccine shows cross-protective efficacy against four oncogenic non-vaccine HPV types
Wednesday, November 09, 2011

Biolimus Stents Noninferior to Sirolimus Stents
Biolimus-eluting stents are noninferior to sirolimus eluting stents in coronary artery disease
Wednesday, November 09, 2011

Varying Response to Etanercept in Juvenile Arthritis
Excellent response tied to low disability scores, prior DMARD use, younger age at onset
Wednesday, November 09, 2011

Adjuvant Bevacizumab Feasible in Ovarian Cancer
Progression-free survival similar to IP, IV therapy; higher risk of bowel perforation/obstruction
Wednesday, November 09, 2011

Poxviral Vaccine Benefits Some With Ovarian, Breast Cancer
Some patients with limited tumor burden, minimal chemo exposure benefit from monthly vaccine
Tuesday, November 08, 2011

No Added Benefits of Cranial Bypass in Stroke Prevention
For patients with atherosclerotic internal carotid artery occlusion, surgery doesn't cut stroke risk
Tuesday, November 08, 2011

Evidence Lacking for Pridopidine Efficacy in Huntington's Disease
Although treatment did not meet prespecified efficacy, potential effect on motor phenotype seen
Tuesday, November 08, 2011

Ridaforolimus Promising for Treating Advanced Sarcomas
Clinical benefit seen for patients with advanced sarcomas of different histopathologic subtypes
Tuesday, November 08, 2011

Substance Use, Abuse Highest Among Native American Teens
Marijuana, then analgesic opioids most commonly used illegal drugs in all racial/ethnic groups
Tuesday, November 08, 2011

Great Achievement at Young Age Function of Time, Not Field
Age dynamics tied to proportion of theoretical work, age of attainment of foundation knowledge
Monday, November 07, 2011

ACAAI: Statin Treatment Tied to Worse Asthma Control
Worsened FEV1, increased nocturnal awakenings, rescue medication use, and daytime symptoms
Monday, November 07, 2011

ACAAI: RNS60 Safe, Promising for Mild to Moderate Asthma
RNS60 improves physiological parameters without adverse events or safety concerns in Phase I trial
Monday, November 07, 2011

Impact of Exercise Lessened by Metformin in Prediabetes
No significant difference for exercise, metformin, combo; but metformin attenuates exercise effect
Monday, November 07, 2011

Exenatide Tied to Modest Weight Loss for Obese Women
A subset of women, termed high responders, lost 5 percent or more of their body weight
Monday, November 07, 2011

K2 Linked to Cases of ST-Elevation Myocardial Infarction
Awareness of K2 health implications should be raised after MIs within days of reported K2 use
Monday, November 07, 2011

Causal Link Suggested Between Acetaminophen Use, Asthma
Children at risk or with asthma should avoid acetaminophen until safety is documented
Monday, November 07, 2011

ACR: Vitamin D Beneficial in Systemic Lupus Erythematosus
And, interferon-α-kinoid immunization is safe, shows promise for SLE
Monday, November 07, 2011

Statin Use in BAV Stenosis Tied to Ascending Aortic Size
Significantly reduced ascending aortic size in patients treated with statins versus untreated
Friday, November 04, 2011

FDA Enhancing Surveillance for Anti-TNF Malignancy
Physicians requested to be alert, report cases of hepatosplenic T-cell lymphoma
Friday, November 04, 2011

Varenicline Tied to Increased Risk of Suicidal Behavior
Varenicline ups suicide/self-injury or depression more than bupropion, nicotine replacement
Friday, November 04, 2011

Receptionists Contribute to Safety of Repeat Prescriptions
Clinicians often unaware of input of receptionists and administrative staff in repeat prescribing
Friday, November 04, 2011

EGFR Level Predicts Survival Benefit of Cetuximab in NSCLC
Patients with high EGFR expression survive longer if they receive cetuximab in addition to chemo
Friday, November 04, 2011

Rooms of Patients With A. baumannii Often Contaminated
Supply carts, floors, infusion pumps, ventilator touch pads are most commonly contaminated
Friday, November 04, 2011

Carisoprodol-Related Emergency Visits Up in United States
Most ER visits involving carisoprodol involve another drug; usually narcotics or benzodiazepines
Thursday, November 03, 2011

ZDN/IFN-α Ups Survival in T-Cell Leukemia/Lymphoma
Combination of zidovudine, interferon α with chemo prolongs survival in acute, lymphoma ATLL
Thursday, November 03, 2011

No Concerning Patterns Seen With H1N1 Vaccine in Pregnancy
Reports to the Vaccine Adverse Event Reporting System indicate 2009 H1N1 vaccination is safe
Thursday, November 03, 2011

Prophylactic Therapy Reduces Bleeding in Hemophilia A
Prophylaxis with anti-inhibitor coagulant complex cuts bleeding events versus on-demand therapy
Wednesday, November 02, 2011

Ivacaftor Safe, Efficacious for Cystic Fibrosis
Improves pulmonary exacerbation, respiratory symptoms, weight, sweat chloride levels
Wednesday, November 02, 2011

CDC: Opioid Overdoses Have Reached Epidemic Proportions
Overdose death rates, sales, OPR-related treatment admissions increased between 1999 and 2008
Wednesday, November 02, 2011

HPV Testing in Self-Collected Samples Has High Sensitivity
Home-HPV testing is more sensitive than cervical cytology, but has lower positive predictive value
Wednesday, November 02, 2011

ADHD Drug Use Not Tied to Serious Cardiovascular Events
Current ADHD drug use does not significantly increase risk of stroke, MI, cardiac death
Tuesday, November 01, 2011

Exparel Approved for Post-Surgery Pain
Provides relief up to 72 hours
Monday, October 31, 2011

Universal Teen Substance Use Approach Recommended
Pediatricians should recommend screening, brief intervention, and/or referral to treatment
Monday, October 31, 2011

APHA: Rates of Personal Belief Vaccination Exemptions Are Up
Ten percent of kindergarteners in California attend school with rates of PBE exceeding 5 percent
Monday, October 31, 2011

Pre-Op Erythropoietin Reduces Need for Peri-Op Transfusion
Also reduces the number of units of erythrocytes transfused during and after surgery
Monday, October 31, 2011

Complete Remission for Many With Nonsyndromic Epilepsy
Two-year seizure outcome and underlying cause offer imperfect prediction of complete remission
Monday, October 31, 2011

Switching From IV to Oral Meds Cuts Health Care Costs
In patients eligible for oral intake, switch from IV to oral equivalents cuts hospital costs
Monday, October 31, 2011

Thalidomide Effective, Safe in GI Vascular Malformations
No severe adverse effects, minor side effects common with thalidomide treatment
Friday, October 28, 2011

Nonclinical Factors Impact Back Pain Treatment Decisions
Patient presentation, socioeconomic status, gender influence physician treatment decisions
Friday, October 28, 2011

Long-Term Aspirin Use Lowers CRC Risk in Lynch Syndrome
Long-term aspirin use benefits individuals with increased hereditary risk of colorectal cancer
Friday, October 28, 2011

Cannabinoid Receptor Tied to Cognitive Chaos
Disrupted hippocampal and mPFC coordination may induce impaired memory and cognition in rats
Thursday, October 27, 2011

Study Finds Statins Don't Slow Atherosclerosis in Pediatric SLE
No difference in mean-mean common carotid intima-media thickening with atorvastatin, placebo
Thursday, October 27, 2011

CDC to Discontinue Provision of Botulinum Toxoid Vaccine
Decision applies to workers in occupational risk of exposure
Thursday, October 27, 2011

Obesity Tied to Impaired Immunity After Flu Vaccine
Reduced levels of influenza antibody titers, decreased CD8⁺ T-cell responses in obese
Thursday, October 27, 2011

Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life
Increased risk of ovarian stimulation for IVF seen in particular with borderline ovarian tumors
Thursday, October 27, 2011

Bedside Geriatric Assessment Feasible in Elderly With AML
Adds information to standard oncology assessment in older patients with acute myelogenous leukemia
Thursday, October 27, 2011

Briakinumab More Effective Than Methotrexate in Psoriasis
Although more frequent serious infections and cancers seen with briakinumab
Thursday, October 27, 2011

qHPV Vaccine Efficacious in Anal Intraepithelial Neoplasia
Quadrivalent vaccine cuts rate of anal intraepithelial neoplasia in men who have sex with men
Wednesday, October 26, 2011

Bedtime Medications Offer Better BP Control in CKD
Taking at least one medication at bedtime reduces sleep-time, ambulatory BP, cardiovascular events
Wednesday, October 26, 2011

AAPS: Transdermal Patch Shows Promise for HIV Therapy
IQP-0410 transdermal patch is non-toxic, doesn't degrade, and has potent in vitro activity
Wednesday, October 26, 2011

Ghost Authorship Prevalent in About One-Fifth of Articles
Prevalence of honorary, ghost authorship, down from 29.2 to 21.0 percent from 1996 to 2008
Wednesday, October 26, 2011

Newer Progestogen Types in the Pill Tied to Higher VTE Risk
Increased risk for users of pills with desogestrel, gestodene, drospirenone versus levonorgestrel
Wednesday, October 26, 2011

Evidence Suggests Variable Effectiveness for Flu Vaccine
Randomized controlled trials indicate vaccine efficacy varies between seasons, age groups
Wednesday, October 26, 2011

Clinical, Genetic Factors Linked to Early Stent Thrombosis
Independent association for three genes, two clopidogrel-related factors, clinical factors
Tuesday, October 25, 2011

FDA: Xigris Pulled From Global Market
Drug failed to show survival benefit in severe sepsis
Tuesday, October 25, 2011

CDC Recommends HPV Vaccination in Males
Hope is to reduce spread of HPV
Tuesday, October 25, 2011

AACR: NSAID Use Tied to Lower Colorectal Cancer Mortality
At least 10 years of NSAID use significantly lowers CRC mortality in postmenopausal women
Tuesday, October 25, 2011

Capecitabine First-Line Option in Advanced Breast Cancer Therapy
Similar activity, less toxic, more tolerable than cyclophosphamide, methotrexate, and fluorouracil
Tuesday, October 25, 2011

Vandetanib Ups Survival in Medullary Thyroid Carcinoma
Improved progression-free survival, disease control rate, objective and biochemical response
Tuesday, October 25, 2011

Pre-Op Regimen Tolerable for Esophageal Adenocarcinoma
But fails to meet objective of achieving pathologic complete response of 40 percent
Monday, October 24, 2011

First Versions of Generic Zyprexa Approved
To treat schizophrenia or bipolar disorder
Monday, October 24, 2011

CHEST: Study Looks at Sildenafil Dose for Youth With PAH
Medium doses seem to have best risk-benefit ratio for children with pulmonary artery hypertension
Monday, October 24, 2011

Immunotherapy-Chemo Combo Improves Survival in NSCLC
Addition of TG4010 to standard chemotherapy improves six month progression-free survival
Monday, October 24, 2011

LABA Use Ups Risk of Serious Asthma Events in Children
Concomitant use of inhaled corticosteroids, long acting β²-adrenergic receptor agonists may cut risk
Monday, October 24, 2011

Letrozole Monotherapy Shows Breast CA Long-Term Benefits
Sequential treatments with letrozole and tamoxifen have similar outcomes to letrozole monotherapy
Friday, October 21, 2011

Dopamine Polymorphisms Tied to Methylphenidate Response
Dopamine transporter and receptor polymorphisms associated with variability in dose-response
Friday, October 21, 2011

Tdap Vaccinations Recommended for Families With Newborns
Mothers and close family members should receive boosters
Thursday, October 20, 2011

Postnatal Steroids Mar Preterm Infant Cerebellar Growth
And, agonist of Shh-Smo pathway protects against steroid induced cerebellar injury in neonatal mice
Thursday, October 20, 2011

Intensive Lipid Therapy Lowers Plaque Lipid Content
Carotid plaque lipid content decreases significantly after one year of therapy, lasts in second year
Thursday, October 20, 2011

Drug-Eluting Stents With Abnormal ABI Tied to Mortality
Predictive of one-year all cause, cardiovascular mortality after drug-eluting stent implantation
Thursday, October 20, 2011

Early Initiation of ART After TB Treatment Ups Survival
Risk of death reduced for patients with a CD4+ T-cell count of less than 50 per cubic millimeter
Wednesday, October 19, 2011

Antidepressants Used by About 11 Percent of Americans
Use varies by sex, age, race and other variables
Wednesday, October 19, 2011

Adjuvant S-1 Improves Five-Year Outcomes in Gastric Cancer
Oral fluoropyrimidine derivative, S-1, improves overall, relapse-free survival at five years
Wednesday, October 19, 2011

ASRM: Etiology, Treatment of Hot Flushes Reviewed
Hot flushes likely related to changes in CNS neurotransmitters tied to estrogen withdrawal
Wednesday, October 19, 2011

Maternal ACE Inhibitor Use Not Tied to Congenital Defects
First trimester use of ACE inhibitors has a similar risk profile to use of other antihypertensives
Wednesday, October 19, 2011

Readmission Risk Models Display Poor Predictive Ability
Current hospital readmission risk models for comparative or clinical purposes perform poorly
Tuesday, October 18, 2011

Topotecan Induction Feasible for High-Risk Neuroblastoma
No deaths or dose-limiting toxicities with dose-intensive topotecan, cyclophosphamide induction
Tuesday, October 18, 2011

Addition of Dulanermin Doesn't Improve Outcomes in NSCLC
Patients with advanced or recurrent non-small-cell lung cancer do not benefit from dulanermin
Tuesday, October 18, 2011

ASA: Obesity Ups Peri-Op Peds Respiratory Complications
And, significantly lower effective dose of propofol causes loss of consciousness in obese children
Monday, October 17, 2011

Exercise Shows Potential for Migraine Prophylaxis
Reduction in migraine frequency similar for exercise, relaxation, and topiramate treatment
Monday, October 17, 2011

No Effect of Prophylaxis Type on Pulmonary Embolism Rate
Prophylaxis agent, anesthesia type do not affect pulmonary embolism rate post hip arthroplasty
Friday, October 14, 2011

Patients Remain Seizure-Free Long After Epilepsy Surgery
Seizure recurrence varies with the type of surgical treatment
Friday, October 14, 2011

Pediatric Asthma Drug Prescriptions on the Upswing
Costs associated with medications significantly up since late 1990s
Thursday, October 13, 2011

Vitamin D Dependent Pathway Key in Immunity Against TB
T cells release interferon-γ to induce antimicrobial activities by human macrophages
Thursday, October 13, 2011

Polytherapy With Valproate Ups Fetal Malformation Risk
Higher risk of malformation with carbamazepine, lamotrigine polytherapy with valproate
Wednesday, October 12, 2011

Flu Vaccine With Adjuvant MF59 Efficacious in Infants
Oil-in-water emulsion adjuvant vaccine has 75 percent relative efficacy versus non-adjuvant shot
Wednesday, October 12, 2011

Financial Conflicts of Interest Prevalent, Under-Reported
Conflicts of interest prevalent; under-reported by members, chairs of panels developing guidelines
Wednesday, October 12, 2011

Long-Term Vitamin E Use Increases Prostate Cancer Risk
Absolute increase in prostate cancer risk 1.6 per 1,000 person-years with long-term vitamin E
Wednesday, October 12, 2011

Prenatal Folic Acid Cuts Severe Language Delay in Offspring
Children of mothers taking prenatal folic acid have lower risk of severe language delay
Wednesday, October 12, 2011

Colon Inflammation Markers Lower With Ginger Extract
Significant decrease in mean percent change in two markers when normalized to free arachidonic acids
Tuesday, October 11, 2011

Leukemia Drug May Cause Pulmonary Arterial Hypertension
PAH seen in patients taking Sprycel
Tuesday, October 11, 2011

High Yield of Viral Diagnoses for RT-PCR in Respiratory Infection
But, rapid communication of RT-PCR results to clinicians has no benefit on patient care
Tuesday, October 11, 2011

Fludarabine, Alemtuzumab Combo Ups Survival in CLL
But combination therapy is associated with more adverse events than fludarabine monotherapy
Tuesday, October 11, 2011

Some Dietary Supplements Up Mortality Risk in Older Women
Several common vitamin, mineral supplements increase mortality risk; calcium lowers risk
Tuesday, October 11, 2011

Natalizumab Effective for Relapsing-Remitting MS
Treatment well-tolerated over two years, but adverse events reported more frequently after NTZ
Monday, October 10, 2011

High Chocolate Consumption Tied to Lower Risk of Stroke
Significantly reduced risk of stroke for women in the highest quartile of chocolate consumption
Monday, October 10, 2011

Septicemia Most Costly Reason for Hospitalization in 2009
Almost one in 23 patients had septicemia; average of 4,600 new patients treated each day
Monday, October 10, 2011

Improved Virologic Response After Triple Class Failure in HIV
Improvement in viral load suppression, decrease in rate of AIDS likely due to new meds
Monday, October 10, 2011

Upfront Zoledronic Acid Ups Bone Density in Breast Cancer
Increases bone mineral density in postmenopausal women receiving aromatase inhibitors
Monday, October 10, 2011

Juvisync Approved for Type 2 Diabetics With High Cholesterol
Previously approved meds combined in one tablet
Friday, October 07, 2011

Infliximab Improves Clinical Outcome in Ulcerative Colitis
Early mucosal healing with infliximab improves long-term outcome, reduces need for colectomy
Friday, October 07, 2011

Cialis Approved to Treat Benign Prostatic Hyperplasia
Also approved for treatment of BPH and erectile dysfunction occurring simultaneously
Friday, October 07, 2011

Anti-TNF-α Use Cuts Diabetes Risk in Rheumatoid Arthritis
Rheumatoid arthritis patients have a 51 percent reduced risk of diabetes with anti-TNF-α use
Friday, October 07, 2011

Use of Oral Steroids Linked to Vitamin D Deficiency
Steroid users have more than two-fold increased risk of vitamin D deficiency than steroid nonusers
Thursday, October 06, 2011

Nonanthracycline Trastuzumab Regimen Safe and Effective
Similar survival to AC-T plus trastuzumab; fewer acute toxic effects in HER2-positive breast cancer
Thursday, October 06, 2011

Prolonged Exposure, Cognitive Therapy Prevent Chronic PTSD
Prolonged exposure, cognitive therapy, delayed PE, but not escitalopram, placebo prevent chronic PTSD
Thursday, October 06, 2011

More Minority Patients in Low-Quality, High-Cost Hospitals
More elderly black, Hispanic, Medicaid patients consult worst rather than best hospitals
Thursday, October 06, 2011

Oral Acyclovir Improves Outcomes in Neonatal Herpes
Six-month acyclovir therapy improves neurodevelopment in infants with CNS involvement
Thursday, October 06, 2011

Health Risks for Women Exposed to DES in Utero
Increased adverse outcomes for diethylstilbestrol-exposed women with vaginal epithelial changes
Wednesday, October 05, 2011

Feasible to Stop Post-Renal Transplant Anti-Rejection Meds
Lymphoid irradiation, donor stem cells eliminate immunosuppressant use post-renal transplant
Wednesday, October 05, 2011

Oral Teriflunomide Effective in Relapsing Multiple Sclerosis
Oral teriflunomide significantly reduces relapse rates, disease progression, MRI disease evidence
Wednesday, October 05, 2011

High Children's Asthma Care Compliance in Peds Hospitals
But moderate compliance for post-discharge home-management plan of asthma care in children
Tuesday, October 04, 2011

Prior DNA Priming Ups Influenza Vaccine Effectiveness
H5-DNA priming 24 weeks pre-H5N1 monovalent inactivated vaccine increases immune response
Tuesday, October 04, 2011

Hormonal Contraceptives May Up HIV-1 Acquisition by Women
Also tied to increased risk of HIV-1 transmission from HIV-1 infected women to men
Tuesday, October 04, 2011

Flibanserin Effective Therapy for Hypoactive Sexual Desire
Superior for change in the number of sexual satisfying events, desire in premenopausal women
Monday, October 03, 2011

About One in 10 Parents Use Alternate Vaccination Schedule
Non-blacks, those without regular child health care provider use alternative schedule more
Monday, October 03, 2011

Activated Protein C Inhibitor Effective in Hemophilia A
Specific APC inhibitor PNASN-1 increases thrombin generation to near normal in FVIII deficiency
Friday, September 30, 2011

Aspirin Resistance Is Relatively Common Phenomenon
But poor compliance may contribute to substantial number of apparent resistance cases
Friday, September 30, 2011

Topiramate Effective in Post-Traumatic Stress Disorder
Re-experiencing symptoms, avoidance/numbing symptoms improve significantly with topiramate
Friday, September 30, 2011

Tamoxifen Use Tied to Diabetes Risk in Breast Cancer Survivors
But aromatase inhibitor use has no association with diabetes in older breast cancer survivors
Friday, September 30, 2011

Surfactants Feasible for Self-Breathing Preterm Infants
Decrease the need for mechanical ventilation in preterm infants breathing spontaneously on CPAP
Friday, September 30, 2011

SSRI With Antiplatelet Therapy Ups Post-MI Bleeding Risk
Selective serotonin reuptake inhibitors with ASA tied to higher bleeding risk than ASA alone
Thursday, September 29, 2011

Slow, Steady Rise in Stimulant Use for ADHD Since 1996
Adolescent use up, decrease in preschoolers, with variations in gender, geography, racial group
Thursday, September 29, 2011

Cytisine More Effective Than Placebo for Smoking Cessation
Higher 12-month abstinence rate with cytisine; cheaper than other pharmacotherapies
Wednesday, September 28, 2011

DNA Repair Capacity IDs Non-Small-Cell Lung Cancer Survival
Worse overall and three-year survival for patients with high DNA repair capacity
Wednesday, September 28, 2011

Increasing Dose of Saw Palmetto No Better Than Placebo in BPH
Results comparable to placebo in benign prostatic hyperplasia-related urinary tract symptoms
Wednesday, September 28, 2011

Calcineurin-Inhibitor-Sparing Regimens Improve Outcomes
Use of calcineurin-inhibitor-sparing regimens immediately after kidney transplant ups outcomes
Wednesday, September 28, 2011

DMARDs Found to Be Effective Treatment for Juvenile Arthritis
But more research is needed to define long-term safety
Wednesday, September 28, 2011

Cognition Similar for Standard, Intensive Glycemic Control
Total brain volume, mortality risk higher with intensive glycemic lowering for type 2 diabetes
Wednesday, September 28, 2011

Quadrivalent HPV Vaccine More Cost-Effective Than Bivalent
Bivalent vaccine should be about £19 to £35 cheaper to be as cost-effective as quadrivalent
Wednesday, September 28, 2011

Benefits, Harms With Off-Label Atypical Antipsychotic Use
Adverse events common; favorable response varies with drug and off-label condition being treated
Tuesday, September 27, 2011

Cell of Origin Key in Relapsed B-Cell Lymphoma Prognosis
Better response in germinal center B-like diffuse large B-cell lymphoma with R-DHAP therapy
Tuesday, September 27, 2011

ESR1 Expression Predicts Tamoxifen Benefit in Breast CA
Lower expression of ESR1 determines tamoxifen resistance in ER-positive breast tumors
Tuesday, September 27, 2011

Asthma Prevalence Elevated in Youth With Diabetes
Asthma associated with poor glycemic control in youth with type 1 diabetes, especially if untreated
Tuesday, September 27, 2011

Remicade Approved for Ulcerative Colitis in Children
Aged six and older
Monday, September 26, 2011

Tdap Safe After Tetanus-, Diphtheria-Containing Products
Children age 7 to 10 susceptible to pertussis and under-immunized should receive single Tdap dose
Monday, September 26, 2011

Updated Guides Compare Treatments for GERD
Both drug therapies and surgeries considered effective
Monday, September 26, 2011

Evidence for Nondrug Childhood Constipation Therapies Limited
Some evidence for effectiveness of fibers, but not for fluids, biotics, behavioral therapy
Monday, September 26, 2011

GLCCI1 SNP Lowers Response to Inhaled Steroids in Asthma
rs37973 single neucleotide polymorphism tied to decreased inhaled glucocorticoid response
Monday, September 26, 2011

Adjuvant Zoledronic Acid Not Beneficial in Breast Cancer
Disease-free, overall survival in early-stage breast cancer not improved by zoledronic acid
Monday, September 26, 2011

Generic Tacrolimus Safe for Liver, Kidney Recipients
No change in liver, kidney function; no rejection seen after substitution for reference product
Monday, September 26, 2011

Glucagon-Like Peptide-1 Therapy Ups Pancreatitis Risk
Exenatide, sitagliptin up odds ratio of pancreatitis, increase reports of pancreatic cancers
Friday, September 23, 2011

FDA Expands Age Indication for Boostrix
The vaccine is now licensed for use in people 65 and older
Thursday, September 22, 2011

Rotavirus Vaccine Introduction Cut Health Care Use, Costs
National estimated reduction of 64,855 hospitalizations and $278 million in 2007 to 2009
Wednesday, September 21, 2011

F1+2, VEGF, D-Dimer Levels Up in Nonallergic Asthma
Patients exhibit autoreactivity, increased coagulation levels and angiogenesis markers
Wednesday, September 21, 2011

2006/2007 U.S. Flu Vaccination Policy Lowers Morbidity
Expansion of vaccination policy to include healthy children cuts influenza morbidity by 34 percent
Wednesday, September 21, 2011

Mortality Up in Hospitals With More Minority Trauma Patients
Trauma patients' odds of mortality linked to the proportion of minority patients in the hospital
Wednesday, September 21, 2011

Age, Treating Physician Tied to Pediatric Psoriasis Treatment
Dermatologists, internists prescribe high-potency steroids; pediatricians prescribe topical tacrolimus
Wednesday, September 21, 2011

Cognitive Behavior Therapy, SRIs Improve OCD Treatment
Better response in pediatric obsessive compulsive disorder than medication management alone
Tuesday, September 20, 2011

Payer Status Affects Health Care Quality and Outcomes
Heart failure patients without private insurance/HMO have poorer care, worse outcomes
Tuesday, September 20, 2011

Lower Sudden Death Risk With Add-On Antiepileptic Therapy
Treatment tied to reduction of sudden death incidence in patients with refractory epilepsy
Tuesday, September 20, 2011

Tasquinimod Ups Castration-Resistant Prostate CA Survival
Delays disease progression, ups progression-free survival with acceptable adverse event profile
Tuesday, September 20, 2011

Mycophenolate Mofetil Safe, Effective for Refractory Lupus
MMF, standard therapy tolerated for antimalarial-resistant cutaneous lupus erythematosus
Tuesday, September 20, 2011

Enoxaparin Bests Unfractionated Heparin in Occlusive PAD
Enoxaparin performs better than unfractionated heparin in peripheral arterial occlusive disease
Monday, September 19, 2011

Fluoroquinolones Up Risk of Post-Biopsy Acute Prostatitis
Isolated gram-negative bacteria were fluoroquinolone-resistant in 85.7 percent of cultures
Friday, September 16, 2011

Child Self-Exposure to Meds Explains Most Drug Poisoning
Child self-exposure accounts for 95 percent of emergency visits from 2001 to 2008 in U.S.
Friday, September 16, 2011

CDC: MRSA USA300 Strain Resistant to Topical Antibiotics
Most MRSA isolates susceptible to bacitracin, but USA300 isolates resistant to bacitracin, neomycin
Friday, September 16, 2011

Statins After Ischemic Stroke Not Tied to Brain Hemorrhage
Similar lack of association found for subgroups and dose-response analyses
Friday, September 16, 2011

CDC: Risk Factors ID'd in Most C. difficile Diarrhea Cases
Traditional risk factors, including antimicrobial use, hospitalization, account for majority of cases
Thursday, September 15, 2011

AACR: Genetic Data ID Breast Cancer Progression Pathways
Identification of pathways, driver genes leads to novel targeted therapy for breast cancer
Thursday, September 15, 2011

CDC: Recent Influenza Activity Relatively Low
Annual vaccinations still needed to prevent flu and complications
Thursday, September 15, 2011

Anti-Nausea Drug May Lead to Dangerous Heart Rhythms
FDA alerts public to ongoing safety review for Zofran
Thursday, September 15, 2011

Specific Pain Reduction Seen With Transdermal Buprenorphine
Buprenorphine, but not fentanyl, significantly reduces bone pain and primary hyperalgesia
Thursday, September 15, 2011

Long-Term Nonaspirin NSAID Use Ups Renal Cell Cancer Risk
Nonsteroidal anti-inflammatory drugs, but not aspirin or acetaminophen, increase RCC risk
Wednesday, September 14, 2011

Reduced Treatment Time Noninferior for Some With Hep C
Hepatitis C virologic response similar with peginterferon-ribavirin for 24 versus 48 weeks
Wednesday, September 14, 2011

No Benefit of Long-Term Azithromycin for Rhinosinusitis
Low weekly dose of 500 mg for 11 weeks provides no benefit over placebo in chronic rhinosinusitis
Wednesday, September 14, 2011

Erectile Dysfunction Ups Risk of Cardiovascular Disease
Increased risk of cardiovascular disease, coronary heart disease, stroke, all-cause mortality
Wednesday, September 14, 2011

Sorafenib Plus DEB-TACE Safe, Tolerated in Unresectable HCC
Adverse events for transarterial chemoembolization with doxorubicin-eluting beads, sorafenib mostly mild
Wednesday, September 14, 2011

Many Mistakenly Believe FDA OKs Only Safe, Effective Drugs
Consumer explanations about safety, efficacy of drugs help public make better decisions
Wednesday, September 14, 2011

Venlafaxine, Clonidine Reduce Hot Flashes in Breast Cancer
Immediate reduction in hot flash scores with venlafaxine; lower week 12 scores with clonidine
Tuesday, September 13, 2011

Dalcetrapib Use Safe, Possibly Beneficial in Atherosclerosis
Dalcetrapib use reduces change in total vessel area, most-diseased segment over 24 months
Tuesday, September 13, 2011

Insulin Therapy May Slow Alzheimer's Progression
Pilot study shows intranasal delivery of the agent to be beneficial
Tuesday, September 13, 2011

TNF Inhibitors for RA Do Not Increase Malignancy Risk
But tumor necrosis factor inhibitor exposure ups non-melanoma skin cancer and melanoma risk
Monday, September 12, 2011

Clopidogrel Adherence Tied to Daily Pre-PCI Med Adherence
Low adherence also tied to cost; physician, pharmacy access; patient-provider communication
Monday, September 12, 2011

Opioid Delivery to Olfactory Region Ups Therapeutic Effects
More of drug delivered to central nervous system, no increase in plasma drug exposure in rats
Friday, September 09, 2011

Oxycodone No Safer Than Codeine During Breastfeeding
One in five breastfed infants exposed to oxycodone has central nervous system depression
Friday, September 09, 2011

SAMHSA Assesses Recent Trends in Illicit Drug Use
Illicit drugs and alcohol use in 2010 similar to that in 2009, but higher than in 2008
Thursday, September 08, 2011

Comparative Efficacy Proposed for European Drug Approval
Superiority, equivalence, inferiority of new drugs should be compared with existing therapies
Wednesday, September 07, 2011

Many Hospital Staff Uniforms Contaminated With Bacteria
More than 60 percent of uniforms are contaminated, with similar rates between nurses, physicians
Wednesday, September 07, 2011

Gestational NSAID Intake Tied to Spontaneous Abortion Risk
Risk increases with any type, dosage of nonaspirin NSAIDs separately or in combination
Wednesday, September 07, 2011

Hospitalized Children Exposed to Considerable Polypharmacy
Pediatric patients with rare conditions have significantly greater likelihood of polypharmacy
Tuesday, September 06, 2011

Immunoadsorption Therapy Effective in E. coli-Induced HUS
Immunoadsorption effective, safe for neurological complications of hemolytic uremic syndrome
Tuesday, September 06, 2011

Vaccine Rates Increase Among Children Aged 11 to 12 Years
However, often not all of the recommended vaccines are administered during vaccination visits
Tuesday, September 06, 2011

Temp Staff Errors More Harmful Than Those of Permanent Staff
Medication errors by temporary staff more likely to be life-threatening or harmful
Monday, September 05, 2011

FDA: Antipsychotic Drug May Cause Severe Allergic Reaction
FDA advises of updated label for Saphris reflecting risk
Friday, September 02, 2011

Antibiotic Prescriptions Down for Pediatric Patients
But the drugs continue to be overprescribed for those aged 14 and under
Friday, September 02, 2011

Pediatric Vaccination Rates High in United States
Still room for improvement in under-vaccinated populations
Thursday, September 01, 2011

Success With Valproic Acid for Glioblastoma With TMZ Therapy
Valproic acid better than enzyme-inducing drugs for patients with glioblastoma needing antiepileptic
Thursday, September 01, 2011

Four Categories of Eligibility for Contraceptive Use Endorsed
ACOG endorse use of 2010 U.S. Medical Eligibility Criteria for Contraceptive Use
Tuesday, August 30, 2011

AAP Recommends Quadrivalent MMRV for Most Children
But separate MMR, varicella vaccines indicated for children with personal/family history of seizures
Tuesday, August 30, 2011

Drug-Eluting Stents Better for Saphenous Vein Graft Lesions
Better clinical, angiographic outcomes with drug-eluting versus bare-metal stents one year later
Monday, August 29, 2011

ESC: Preventive Drug Use Tied to Country's Economic Status
Preventive drug use in cardiovascular disease varies with country's economic status
Monday, August 29, 2011

Apixaban Superior to Warfarin for Stroke Prevention in A-Fib
Apixaban reduces stroke risk, embolism, bleeding, and mortality in patients with atrial fibrillation
Monday, August 29, 2011

Colchicine Safe, Effective Adjunct in Recurrent Pericarditis
Data reveals drug safe and effective for secondary prevention of recurrent pericarditis
Monday, August 29, 2011

Loss of Jobs Means Loss of Health Coverage for Many in U.S.
Majority report delay in getting needed healthcare and financial difficulties paying medical bills
Monday, August 29, 2011

IOM: Few Health Issues Caused By Vaccines
Report should alleviate parental fears regarding vaccination of their children
Friday, August 26, 2011

Extended-Release Opioid Pain Medication Approved
Nucynta ER sanctioned for chronic pain in adults
Friday, August 26, 2011

Expedited Partner Therapy Use Benefits Gonorrhea, Chlamydia
In states where expedited partner therapy is not legal, practitioners should advocate for legality
Friday, August 26, 2011

Complementary Medicine Used More by Health Care Workers
U.S. health care providers use complementary, alternative medicine more than support workers
Friday, August 26, 2011

Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines
Only 18.1 percent of advertisements fully adhere to FDA guidelines, over half do not quantify serious risks
Thursday, August 25, 2011

CDC: HPV Vaccine Rates Lag Behind Other Teen Vaccines
Report reveals vaccine coverage increased from 2009 to 2010 among adolescents aged 13-17 years
Thursday, August 25, 2011

Firazyr Approved for Acute Hereditary Angioedema
Most common side effects: injection site reactions, fever, increase in liver enzymes, dizziness, rash
Thursday, August 25, 2011

Azithromycin Decreases COPD Exacerbation Frequency
Daily azithromycin for one year reduces COPD exacerbations in selected patients
Wednesday, August 24, 2011

Botox Approved to Treat Urinary Incontinence
For use among people with certain neurologic conditions
Wednesday, August 24, 2011

Hospitalization Ups Unintentional Discontinuation of Meds
Discontinuation of medications higher in patients with ICU admissions than in non-ICU admissions
Tuesday, August 23, 2011

NSAID Intolerance Indicative of Intolerance to Etoricoxib
Patients with urticaria or angioedema reactions to NSAIDs may also be intolerant to etoricoxib
Monday, August 22, 2011

Similar Platelet Response With 50 or 100 mg Dose of Aspirin
No difference in platelet response, cardiovascular events with 50 or 100 mg aspirin for five years
Monday, August 22, 2011

Methotrexate Lowers Response to Pneumococcal Vaccine
In patients with arthritis, methotrexate reduces antibody response after pneumococcal vaccination
Monday, August 22, 2011

CDC: 2010/2011 Flu Vaccination Coverage Studied
Coverage in health care personnel and pregnant women remained stable versus previous season
Thursday, August 18, 2011

CDC: Flu Vaccine Recommendations Unchanged
Flu vaccine recommended in those ≥6 months; strains same as previous season
Thursday, August 18, 2011

Chinese Herbal Decoction Cuts Time to H1N1 Fever Resolution
Maxingshigan-yinqiaosan effective alone and in combination with oseltamivir
Tuesday, August 16, 2011

Evidence Lacking That Aspirin Use in IVF Improves Birth Rate
Lack of evidence for effect of aspirin on clinical pregnancy, ectopic, and miscarriage rates
Thursday, August 11, 2011

More Neurology Residents Comfortable Using tPA for Stroke
Residents' experience, comfort using tPA to treat acute ischemic stroke increased from 2000 to 2010
Monday, August 08, 2011

Cost of Interacting With Payers Higher in U.S. Than Canada
U.S. physicians and nursing staff spend more time and money interacting with health plans
Friday, August 05, 2011

Antidepressant Prescriptions for Non-Psych Disorders Up
Non-psychiatrists' antidepressant prescriptions without psych diagnosis rise from 1996 to 2007
Friday, August 05, 2011

CDC: Age Range Expanded for Meningococcal Vaccine
Report reveals that two licensed meningococcal conjugate vaccines likely interchangeable
Thursday, August 04, 2011

Teens Who Misuse Controlled Meds More Likely to Abuse Drugs
Among teens who take controlled meds, 22 percent report misuse, including intentionally getting high
Thursday, August 04, 2011

FDA: High-Dose Fluconazole Tied to Birth Defects
Chronic use during first trimester may lead to rare and distinct set of birth defects
Wednesday, August 03, 2011

High Doses of Zinc Found to Reduce Common Cold Duration
Daily use of lozenges with more than 75 mg zinc acetate reduces cold duration by 42 percent
Wednesday, August 03, 2011

High Risk of Adverse Outcomes Tied to SSRI Use in Elderly
Increased risk with selective serotonin reuptake inhibitors, other drugs than tricyclic antidepressants
Wednesday, August 03, 2011

Risperidone Not Effective for Military-Related PTSD
Side effects occur without reduction in posttraumatic stress disorder symptoms in veterans
Tuesday, August 02, 2011

Lower Risk of Repeat Vascular Events in Young Adults on Statins
Young adults with ischemic stroke of undetermined etiology benefit from statin therapy
Tuesday, August 02, 2011

DHA Intake in Pregnancy Tied to Fewer Colds in Infants
Maternal intake of docosahexaenoic acid during pregnancy reduces some illness symptoms in infants
Monday, August 01, 2011

Low-Molecular-Weight Heparin Better for Primary PCI
Compared to unfractionated heparin, reduced mortality and bleeding for patients with STEMI
Friday, July 29, 2011

Apixaban Ups Bleeding Without Reducing Ischemic Events
Trial evaluating addition of apixaban to antiplatelet therapy terminated prematurely
Tuesday, July 26, 2011

Propranolol Safe and Effective for Infantile Hemangiomas
Volume, color, and elevation of infantile hemagiomas improve with propranolol treatment
Tuesday, July 26, 2011

FDA: Chantix Tied to Slight Risk of Cardiac Events
Patients with cardiovascular disease may have higher risk of certain cardiac events
Monday, July 25, 2011