atezolizumab
Tecentriq
Pharmaceutical company: Genentech
NEW INDICATION & DOSAGE
Unresectable or metastatic alveolar soft part sarcoma
Adults: 840-mg IV infusion every 2 weeks, or 1,200 mg every 3 weeks, or 1,680 mg every 4 weeks until disease progression or unacceptable toxicity occurs.
Children age 2 and older: 15-mg/kg IV infusion (up to a maximum of 1,200 mg) every 3 weeks until disease progression or unacceptable toxicity occurs.
Released: February 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
cariprazine
Vraylar
Pharmaceutical company: AbbVie
NEW INDICATION & DOSAGE
Adjunctive therapy to antidepressants for the treatment of major depressive disorder
Adults: Initially, 1.5 mg PO once daily. May increase to 3 mg once daily on day 15 based on patient’s response and tolerability. Maximum dosage is 3 mg daily.
Released: February 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
ibrexafungerp
Brexafemme
Pharmaceutical company: Scynexis, Inc.
NEW INDICATION & DOSAGE
Reduction of incidence of recurrent vulvovaginal candidiasis
Adult and pediatric females who are postmenarchal: 300 mg (two 150 mg tablets) PO approximately 12 hours apart for 1 day for a total daily dosage of 600 mg monthly for 6 months.
Adjust-a-dose: If concomitantly used with strong CYP3A inhibitor, give one 150 mg tablet approximately 12 hours apart for 1 day for a total daily dosage of 300 mg monthly for 6 months.
Released: February 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
tocilizumab
Actemra
Pharmaceutical company: Genentech
NEW INDICATION & DOSAGE
Coronavirus disease 2019 in patients who are hospitalized, receiving systemic corticosteroids, and who require supplemental oxygen, noninvasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation
Adults: 8 mg/kg IV infusion over 60 minutes. If clinical signs or symptoms worsen or don’t improve after the first dose, one additional dose may be given at least 8 hours after the initial infusion. Maximum recommended dosage is 800 mg/infusion.
Adjust-a-dose: Don’t initiate in patients with an ANC below 1,000 per mm 3 , platelet count below 50,000 mm 3 , or ALT or AST above 10 times the upper limit of normal.
Released: February 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer