brentuximab vedotin
Adcetris
Pharmaceutical company: Seagen, Inc.
NEW INDICATION & DOSAGE
Previously untreated high-risk classical Hodgkin lymphoma, in combination with doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide
Children age 2 and older: 1.8 mg/kg IV over 30 minutes every 3 weeks until a maximum of 5 doses, disease progression, or unacceptable toxicity. Maximum dose is 180 mg. Give granulocyte colony stimulating factor beginning with cycle 1.
Adjust-a-dose: Refer to prescribing information for chemotherapy agents for additional information.
Released: January 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
cemiplimab-rwlc
Libtayo
Pharmaceutical company: Regeneron
NEW INDICATION & DOSAGE
Locally advanced or metastatic non–small-cell lung cancer with no EGFR, ALK or ROS1 aberrations as first-line treatment in combination with platinum‐based chemotherapy
Adults: 350-mg IV infusion over 30 minutes every 3 weeks until disease progression or unacceptable toxicity occurs.
Adjust-a-dose: Refer to prescribing information for chemotherapy agents for additional information.
Released: January 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
cobimetinib
Cotellic
Pharmaceutical company: Genentech, Inc.
NEW INDICATION & DOSAGE
Monotherapy for histiocytic neoplasm
Adults: 60 mg PO once daily for the first 21 days of a 28-day cycle until disease progression or unacceptable toxicity.
Adjust-a-dose: Refer to the manufacturer’s instructions for toxicity-related dosage adjustments. If concurrent short-term (14 days or less) use of a moderate CYP3A inhibitor is unavoidable in patients taking cobimetinib 60 mg, decrease cobimetinib dosage to 20 mg daily. Resume pervious dosage after inhibitor is discontinued. Use an alternative to the CYP3A inhibitor in patients taking less than 60 mg.
Released: January 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer
dulaglutide
Trulicity
Pharmaceutical company: Lilly
NEW INDICATION & DOSAGE
Adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes
Children age 10 and older: 0.75 mg subcut one weekly. If after at least 4 weeks additional glycemic control is needed, may increase dosage to the maximum of 1.5 mg weekly.
Released: January 2023
Nursing Drug Handbook
© 2023 Wolters Kluwer