Coffee-Linked Metabolites Tied to Incident Chronic Kidney Disease

Associations identified for glycochenodeoxycholate, O-methylcatechol sulfate, and 3-methyl catechol sulfate

FRIDAY, Nov. 5, 2021 (HealthDay News) -- Three metabolites that have been identified as associated with coffee consumption are associated with incident chronic kidney disease (CKD), according to a study published online Nov. 4 in the Clinical Journal of the American Society of Nephrology.

William J. He, from Johns Hopkins University in Baltimore, and colleagues identified serum metabolites associated with coffee consumption in two subsamples of the Atherosclerosis Risk in Communities study (ARIC; 3,811 individuals). The associations were replicated in the Bogalusa Heart Study (BHS; 1,043 individuals). The prospective associations between metabolites with significant associations with coffee in both cohorts and incident CKD in ARIC were examined.

The researchers identified 41 metabolites that were associated with coffee consumption in a meta-analysis of the two subsamples of ARIC; of these, 20 were replicated in BHS. In ARIC, three of these 20 coffee-associated metabolites were associated with incident CKD (glycochenodeoxycholate, O-methylcatechol sulfate, and 3-methyl catechol sulfate). Glycochenodeoxycholate may contribute to favorable kidney health outcomes associated with coffee consumption, while O-methylcatechol sulfate and 3-methyl catechol sulfate may represent potential harmful aspects of coffee on kidney health.

"It would have been interesting to see whether the results of He et al. were attenuated when adjusting for self-reported coffee or other diet sources of polyphenols," write the authors of an accompanying editorial. "Integrating these data types should provide a better understanding of the role coffee and other diet factors play in the development of CKD or other diseases."

Several study authors disclosed financial ties to the biopharmaceutical and nutrition industries. One author from the editorial disclosed ties to the pharmaceutical and nutrition industries and reports patents and inventions with Polyphenolics.

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