Success More Than 50 Percent for Second Child With Fertility Treatment

Chances range from 51 to 88 percent depending on use of frozen versus fresh embryos

FRIDAY, May 29, 2020 (HealthDay News) -- Women have a good chance of having a second child with the help of assisted reproductive technology (ART), according to a study published online May 8 in Human Reproduction.

Repon C. Paul, from the University of New South Wales in Sydney, and colleagues evaluated success rates for women returning to ART treatment for a second ART-conceived child. The analysis included 35,290 women who began autologous ART treatment and achieved their first treatment-dependent live birth from treatment performed from January 2009 through December 2013, with follow-up through 2015.

The researchers found that among the women who had their first ART-conceived live birth, 43 percent returned to treatment. Compared with women who underwent a new ovarian stimulation cycle, live birth rates (LBRs) were consistently better in women who recommenced treatment with a previously frozen embryo. The cumulative LBR after six cycles was between 60.9 percent (conservative) and 88.1 percent (optimal) for women who recommenced treatment with a frozen embryo versus between 50.5 and 69.8 percent for those who underwent a new ovarian stimulation cycle. For women ≥35 years, who waited at least three years before returning to treatment or who required either a higher number of ovarian stimulation cycles or double embryo transfer to achieve their first child, the adjusted odds of a second ART-conceived live birth decreased.

"These age-specific success rates can facilitate individualized counseling for the large number of patients hoping to have a second child using ART treatment," the authors write.

Two authors disclosed financial ties to the pharmaceutical industry.

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