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A theoretical model was developed and tested to explain the effects of learned helplessness, self-esteem, and depression on the health practices of homeless women. Data were collected from a sample of 122 homeless women recruited from six shelters. Structural equation analysis was used to evaluate the model. Analysis revealed a goodness-of-fit index of .98, indicating a good fit of the model with the data. Overall, the variables in the model accounted for 14% to 21% of the variance in the health practices of homeless women.