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  1. Aschenbrenner, Diane S. MS, RN


* Hydroxyprogesterone caproate (Makena) is the first drug approved to prevent preterm labor.


* Hydroxyprogesterone caproate is given weekly by injection to women who've had at least one premature birth.


* It's intended for use only in singleton pregnancies.


* Injection-site reactions are the most common adverse effect; others are hives, nausea, and diarrhea.