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  1. Aschenbrenner, Diane S. MS, RN


* The newest monoclonal antibody, ipilimumab (Yervoy), is a targeted therapy for late-stage (metastatic) melanoma and is the first drug shown to prolong life in patients with this condition.


* The drug's most common adverse effects include fatigue, diarrhea, pruritus, rash, and colitis.


* Ipilimumab can have serious and even life-threatening immune-mediated adverse effects, such as enterocolitis, hepatitis, dermatitis, neuropathy, and endocrinopathy.