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  1. Younger, Mary Elizabeth M. PhD, CRNP
  2. Aro, Loris RN
  3. Blouin, William MSN, ARNP, CPNP
  4. Duff, Carla MSN, CPNP, CCRP
  5. Epland, Kristin B. MSN, FNP
  6. Murphy, Elyse BSN, RN
  7. Sedlak, Debra CPNP
  8. Nurse Advisory Committee Immune Deficiency Foundation


Immunoglobulin (Ig) replacement therapy, given as regular infusions of pooled human Ig, is the recognized treatment of humoral immunodeficiencies characterized by hypogammaglobulinemia and impaired antibody responses. It is a safe, effective therapy when delivered by nurses who have been educated to oversee and/or provide these infusions. Guidelines for administration have been developed by the Immune Deficiency Foundation Nurse Advisory Committee to provide a framework and guidance to those nurses administering this therapy.