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canagliflozin, dapagliflozin, empagliflozin, sodium-glucose cotransporter-2 inhibitors, type 2 diabetes mellitus



  1. Novak, Lucia M. MSN, ANP-BC, BC-ADM, CDTC
  2. Kruger, Davida F. MSN, APN-BC, BC-ADM


Abstract: Sodium-glucose cotransporter-2 inhibitors have a unique mechanism of action in the kidneys that causes glucosuria, which lowers plasma glucose. They are also associated with reduced body weight and BP, and a low incidence of hypoglycemia. This article reviews the pharmacologic profiles and clinical implications of canagliflozin, dapagliflozin, and empagliflozin.