The best age for one-time HIV screening is 25 years. The optimal age for a one-time routine HIV screening for adolescents or young adults without known HIV risk factors is 25 years, according to a model-based analysis published in the January Journal of Adolescent Health. The Centers for Disease Control and Prevention currently recommends HIV screening at least once between ages 13 and 64. Among new HIV diagnoses, 22% occur in adolescents and young adults. However, screening rates in this age group are low, and half of 13-to-24-year-olds living with HIV are unaware of their HIV status. Screening at age 25, in addition to current screening practices, would capture the peak incidence of HIV in young people, which occurs between ages 22 and 25.