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  1. Bryant, Rosalind RN-CS, MN, PNP


Several antineoplastic drugs in clinical use may cause hypersensitivity reactions (HSRs) that range from an occasional individual reaction to a significant HSR. Asparaginase preparations have a high incidence of invoking HSRs. The use of an HSR protocol may minimize symptoms experienced by the patient and ensure rapid implementation of life-saving measures when reactions occur. The article will define HSRs, review occurrences, and include a protocol developed to minimize reactions to asparaginase preparations.