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literature review, scleroderma, ulcer, wound healing



  1. Wagner, Keith D. MD, MS
  2. Woolridge, Kate MD
  3. Group, Ashley MD


ABSTRACT: Digital ulcers are a serious complication in 50% of patients with scleroderma. These ulcers have the potential to resist conventional therapies. There have been several reviews of scleroderma care over the last 5 years, but there are new developments in this field that advance clinician knowledge. This review provides an overview of previous digital ulcer management and a concise summary of new peer-reviewed literature on the topic since 2015 to provide guidance to practitioners and researchers seeking well-supported and novel/off-label therapies to consider.