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  1. Mazzuco, Adriana PhD
  2. Souza, Aline Soares PhD
  3. Goulart, Cassia da Luz
  4. Medeiros, Wladimir Musetti PhD
  5. Sperandio, Priscila Abreu PhD
  6. Alencar, Maria Clara Noman PhD
  7. Arbex, Flavio Ferlin PhD
  8. Neder, Jose Alberto PhD
  9. Arena, Ross PhD
  10. Borghi-Silva, Audrey PhD


Purpose: Oxygen uptake () recovery kinetics appears to have considerable value in the assessment of functional capacity in both heart failure (HF) and chronic obstructive pulmonary disease (COPD). Noninvasive positive pressure ventilation (NIPPV) may benefit cardiopulmonary interactions during exercise. However, assessment during the exercise recovery phase is unclear. The purpose of this investigation was to explore the effects of NIPPV on


Methods: Nineteen males (10 HF/9 age- and left ventricular ejection fraction-matched HF-COPD) underwent 2 high-intensity CLE tests at 80% of peak work rate to the limit of tolerance (Tlim), receiving either sham ventilation or NIPPV.


Results: Despite greater recovery kinetics on sham, HF-COPD patients presented with a faster exponential time constant [tau] (76.4 +/- 14.0 sec vs 62.8 +/- 15.2 sec, P < .05) and mean response time (MRT) (86.1 +/- 19.1 sec vs 68.8 +/- 12.0 sec, P < .05) with NIPPV and greater [DELTA]NIPPV-sham ([tau]: 5.6 +/- 19.5 vs -25.2 +/- 22.4, P < .05; MRT: 4.1 +/- 32.2 vs -26.0 +/- 19.2, P < .05) compared with HF. There was no difference regarding Tlim between sham and NIPPV in both groups (P < .05).


Conclusion: Our results suggest that NIPPV accelerated the recovery kinetics following high-intensity CLE to a greater extent in patients with coexisting HF and COPD compared with HF alone. NIPPV should be considered when the objective is to apply high-intensity interval exercise training as an adjunct intervention during a cardiopulmonary rehabilitation program.