Keywords

Crohn's, endothelin-1, endothelin antagonists, ulcerative colitis

Authors

1. Angerio, Allan D. PhD
2. Bufalino, Dominick
3. Bresnick, Melissa
4. Bell, Christine
5. Brill, Sarah

Abstract

Inflammatory bowel disease (IBD) appears to be an inappropriate response to an antigen that leads to chronic inflammation rather than repair. This review looks at the role of endothelin-1 (ET-1) as a proinflammatory agent in IBD. ET-1 antagonists in animal models reduce the incidence and severity of IBD. These antagonists may be useful for treatment of IBD in humans.