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  1. Huddleston, Roseann RN, CRNI(R), OCN
  2. Berkheimer, Carol RN, BSN
  3. Landis, Sandra RN
  4. Houck, Dereen RN, BSN, OCN
  5. Proctor, Ann RN, OCN
  6. Whiteford, Joan RN, BSN


Nurses working in the outpatient ambulatory setting treat patients with multiple infusion drug regimens. Patients can have allergic reactions to infusions ranging from very mild to life-threatening. The reaction and the subsequent treatment measures can be very disconcerting to the patients and to the visitors in the infusion area. The nursing team described in this article took a proactive approach to minimize infusion reactions in the authors' facility, thereby ensuring the safety of other patients. Staff members examined the performance improvement data, conducted a retrospective study, and collaborated with the primary physician providers to develop rechallenge protocols for patients receiving paclitaxel and carboplatin regimens.