CAN YOU IDENTIFY these medications for neurologic disorders? To find out, match each brand name in Section I with its generic name in Section II.

Section I

______ 1. Sunosi (Jazz Pharmaceuticals, Inc.)

______ 2. Dayvigo (Eisai, Inc.)

______ 3. Wakix (Harmony Biosciences)

Section II

a. pitolisant. This medication is used to improve wakefulness in adults with excessive daytime sleepiness or cataplexy associated with narcolepsy. The dosage is titrated over 3 weeks to a maximum recommended dose of 35.6 mg/day if needed. Teach patients to take it upon awakening. Because this drug may prolong the QT interval, it should not be used with other drugs that increase the QT interval or given to patients with or at risk for prolonged QT interval.

b. lemborexant. This orexin receptor antagonist is prescribed to treat insomnia characterized by difficulties with sleep onset and/or sleep maintenance. Teach patients to take it at least 7 hours before the planned time of awakening and tell them that time to sleep onset may be delayed if they take the drug with or soon after a meal. Possible adverse reactions include sleep paralysis, complex sleep behaviors such as sleepwalking, and depression and/or suicidal ideation.

c. solriamfetol. This dopamine and norepinephrine reuptake inhibitor is prescribed to improve wakefulness in adults with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea (OSA). It is not indicated to treat the underlying airway obstruction in OSA. Because this drug may increase BP and heart rate, assess heart rate and BP before initiating treatment and monitor these vital signs periodically throughout treatment. This drug should be avoided in patients with unstable cardiovascular disease.

Answers: 1c, 2b, 3a