1. Ferland, A

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Background and Aims:

C-reactive protein (CRP) is a marker of inflammation and growing evidence suggests that CRP might play an additive role to predict future cardiovascular events in subjects with or without established cardiovascular disease (CVD) or type 2 diabetes. Moreover, regular exercise is well known to offer protection against all-cause mortality, primarily by protection against CVD and type 2 diabetes mellitus as well as lowering impact on CRP levels. Of note, the impact of an acute exercise on CRP concentrations has not been evaluated yet.


Methods and Materials:

The purpose of this study was to evaluate the impact of an acute aerobic exercise on CRP levels in relation to a meal taken before the exercise session. Sixty minutes of exercise was performed at 60% of the subject's peak oxygen uptake (VO2peak) on 3 different occasions, in a random order: 1) 2 hours following a standardized breakfast high in sucrose (HSB) (G: 59%; F: 27%; P: 14%; 452 kcal), 2) high in fat (HFB) (G: 26%; F: 60%; P: 14%; 461 kcal) and, 3) in the fasted state (FS). Ten sedentary diabetic men (mean of age; 55 +/- 13 years, weight; 92.0 +/- 16.5 kg, height; 175 +/- 7 cm and BMI; 29.8 +/- 5.3 kg/m2) performed all 3-exercise sessions. None of the subjects used insulin, and 5 subjects were treated with oral hypoglycemic agents and 5 only with the diet. Blood samples were obtained at rest, after the exercise (60 min), and during the recovery period (90 min). Peak oxygen uptake (VO2peak) was evaluated with a incremental protocol executed on a cycle ergometer, following a warm-up of 1 minute at 15 watts and 2 minutes at 30 watts, the workload was thereafter increased at 15 watts/min until exhaustion.



An increment in plasma CRP was observed at 60 min (P = .007) and returned to the baseline values into the recovery period (P = .3 at 90 min) in the HSB situation. Plasma CRP levels raised following 60 min of aerobic exercise during the HFB situation and remain higher in the recovery period (P = .03 at 90 min) compared to the baseline. However, exercise had no significant impact on plasma CRP levels in the FS situation.



Acute exercise may have various inflammatory impact dependent of the energetic composition of the meal taken before exercise. High sucrose meal might raise CRP levels for a shorter time than high a fat meal. Moreover, exercise performed in the fasted state had no effect on plasma CRP levels.


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