Buy this Article for $10.95

Have a coupon or promotional code? Enter it here:

When you buy this you'll get access to the ePub version, a downloadable PDF, and the ability to print the full article.


  1. Karim, Refaat B. MD, PhD
  2. Brito, Beatriz L.R. MD
  3. Dutrieux, Richard P. MD
  4. Lassance, Fernanda P. PhD
  5. Hage, J. Joris MD, PhD


OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing.


METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, >= 3 months; surface area, >= 1 cm2). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing.


RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing.


CONCLUSION: MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.