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The occurrence of myalgia following statin treatment may be associated with impaired calcium homeostasis, and may indicate an increased risk for malignant hyperthermia for patients receiving halogenated anesthetics. Researchers performed the halothane-caffeine contracture test on muscle biopsy specimens from nine patients. All patients had experienced post-statin muscle pain; none had previously suffered adverse reactions to volatile anesthetics. Abnormal results were found in seven patients, and two patients tested positive for both halothane and caffeine. Researchers conclude that statin treatment should be very carefully considered when dealing with patients who are especially susceptible to malignant hyperthermia, and suggest that creatine kinase levels be assessed before statins are administered.




Douglas D. Statin intolerance may signal malignant hyperthermia risk. Reuters Health. Available at: Accessed December 13, 2006.