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  1. Namey, Marie RN, MSN, MSCN
  2. Halper, June MSCN, ANP, FAAN
  3. O'Leary, Shirley RN, MSCN
  4. Beavin, Jill RN, BSN, MSCN
  5. Bishop, Cynthia RN, BSN, MSCN


Infusion nurses are uniquely positioned to play a vital role in the early identification and management of infusion and hypersensitivity reactions during the administration of biologic therapies. This article reviews the current evidence regarding reactions related to the administration of monoclonal antibodies, namely, natalizumab, a humanized monoclonal antibody against the cellular adhesion molecule [alpha]4-integrin, in patients with multiple sclerosis. In addition to differentiating between infusion and hypersensitivity reactions, the article presents general guidelines for the management of these reactions and provides case studies to better illustrate the use of appropriate interventions.