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Duration - 6:24

Physiology Fundamentals: Third Spacing

In healthy patients, most fluids are confined in three spaces of the body: the intravascular space (in the blood vessels), the intracellular space (in the cells), or the interstitial spaces. The interstitial spaces are the small spaces between cells that are not contained within blood vessels. In normal situations, fluid moves between all three spaces to maintain fluid balance. Third-spacing occurs when too much fluid moves from the intravascular space into the interstitial or “third” space.

Reference:
Holcomb, S. (2009). Topics in Progressive Care: Third-Spacing: When Body Fluids Shifts. Nursing in Critical Care, 4(2). doi: 10.1097/01.NURSE.0000325345.22694.44

Duration - 11:37

Physiology Fundamentals: Sepsis

One of the most important points to remember about sepsis is that it should be treated as a life-threatening medical emergency. In this podcast, Megan Giovanelli Doble, MSN, CRNP, FNP-C, AGACNP-C reviews the basics of sepsis and discusses the latest recommendations on managing patients with sepsis at the bedside.

References:
Levy, M.M., Evans, L.E., & Rhodes, A. (2018). The Surviving Sepsis Campaign Bundle: 2018
Update. Critical Care Medicine, 46(6), 997-1000. doi.org/10.1097/CCM.0000000000003119
 
Rhodes, A., Evans, L., Alhazzani, W., Levy, M., Antonelli, M., Ferrer, R., . . . Dellinger, R. (2017). Surviving
Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016. Critical Care Medicine, 486-452. doi:10.1097/CCM.0000000000002255
 
Singer, M., Deutschman, C.S., Seymour, C.,…Angus, D.C. (2016). The Third International Consensus
Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8), 801-810. doi:10.1001/jama.2016.0287