Authors

  1. Yang, Chuan
  2. Weng, Huan
  3. Chen, Lihong
  4. Yang, Haiyun
  5. Luo, Guangming
  6. Mai, Lifang
  7. Jin, Guoshu
  8. Yan, Li

Abstract

PURPOSE: The purpose of this study was to investigate mean values and cut-point of transcutaneous oxygen pressure (TcPO2) measurement in patients with diabetic foot ulcers.

 

DESIGN: Prospective, descriptive study.

 

SUBJECTS AND SETTING: Sixty-one patients with diabetes mellitus and foot ulcers comprised the sample. The research setting was Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China.

 

METHODS: Participants underwent transcutaneous oxygen (TcPO2) measurement at the dorsum of foot. Patients were classified into 3 groups according to clinical outcomes: (1) ulcers healed with intact skin group, (2) ulcer improved, and (3) ulcer failed to improve. TcPO2 was assessed and cut-points for predicting diabetic foot ulcer healing were calculated.

 

RESULTS: Thirty-six patients healed with intact skin, 8 experienced improvement, and 17 showed no improvement. Mean TcPO2 levels were significantly higher (P< .001) in healed ulcers with intact skin (32 +/- 10 mmHg) when compared to the improvement group (30 +/- 7 mmHg) and the nonhealing group (15 +/- 12 mmHg). All patients with TcPO2<= 10 mmHg failed to heal or experienced deterioration in their foot ulcers. In contrast, all patients with TcPO2>= 40 mmHg achieved wound closure. Measurement of TcPO2 in the supine position revealed a cut-point value of 25 mmHg as the best threshold for predicting diabetic foot ulcer healing; the area under the curve using this cut-point was 0.838 (95% confidence interval = 0.700-0.976). The sensitivity, specificity, positive predictive value, and negative predictive value for TxPO2 were 88.6%, 82.4%, 90.7%, and 72.2%, respectively.

 

CONCLUSION: TcPO2>= 40 mmHg was associated with diabetic foot ulcer healing, but a TcPO2<= 10 mmHg was associated with failure of wound healing. We found that a cut-point of 25 mmHg was most predictive of diabetic foot ulcer healing.