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Number of endoscopies performed not increasing, despite increased prevalence

Cardiometabolic Derangement ID'd in Overweight School Children

Higher levels of fasting glucose, insulin, HOMA-IR, triglycerides, ALT and lower levels of HDL-C seen in overweight school-aged children

DDW: Gallstone Disease May Predict Pancreatic Cancer Incidence

Gallstone presentation may be a missed opportunity for earlier diagnosis

DDW: Antibiotics Up Risk of Older-Onset Inflammatory Bowel Disease

Findings regardless of antibiotic class and with a dose-response relationship

Long-Term Mortality Rates Elevated for Adolescent, Young Adult Leukemia Survivors

Survival for adolescent and young adult leukemia survivors remained below general population at up to 30 years of follow-up

Cessation Program in Cancer Clinics May Reach More Tobacco Smokers

Low-burden, point-of-care program may increase access to and impact of treatment to assist tobacco cessation

50-µg mRNA-1273 Safe, Effective for Children Aged 6 to 11 Years

Estimated vaccine efficacy with two doses was 88.0 percent against COVID-19 at a time when delta was dominant circulating variant

Slight Increase Reported in Lung Cancer, Brain Tumors With Wildfire Exposure

Individuals exposed to wildfire within 50 km of residential locations in past 10 years had slightly higher incidence

Intervention Can Cut Risk for Mobility Disability in Seniors

Reduced incidence of mobility disability seen in older adults with physical frailty and sarcopenia receiving multicomponent intervention

Number of Mesothelioma Deaths Up Among Women From 1999 to 2020

However, age-adjusted death rate per 1 million women decreased significantly, from 4.83 to 4.15 from 1999 to 2020

Rapid Recovery Seen With More Frequent Dialysis in SNFs

Rapid recovery associated with reduced mortality and fewer hospitalizations

Most Patients Have Positive Views About AI in Medicine

However, concern expressed relating to unintended consequences, including misdiagnosis, privacy breaches, less time with clinicians

'Tragic Milestone': One Million American Lives Lost to COVID-19

President Biden has ordered U.S. flags to be flown at half-staff in honor of those lost

Lenacapavir Reduces Viral Load in Multidrug-Resistant HIV-1 Infection

Reduction in viral load from baseline greater with lenacapavir versus placebo among those with multidrug-resistant HIV-1 infection

Digital Breas​t Tomosynthesis Tool Can Help Predict Breast Cancer

DBT-based risk model can predict cancer after a negative screening exam, with high discriminative performance for one-year risk

TXA Seems Safe for Surgery in High-Risk Patients With IT Hip Fracture

No increased risk for mortality or thromboembolic complications seen with use of tranexamic acid among high-risk patients, entire cohort

Previous Myocardial Injury Tied to Worse COVID-19 Outcomes

Significant but weaker associations with selected adverse outcomes seen for preexisting hypertension, diabetes, and ischemic heart disease

FDA Moves to Ease Nationwide Shortage of Baby Formula

The agency's latest moves should help ease the dire situation many mothers face

Lack of Asthma Control More Likely With COVID-19-Related Anxiety

Second study shows most parents of children with food allergy report unchanged or decreased food allergy-specific anxiety during pandemic

Ban of Indoor Tanning Beds Would Reduce Cancers, Cut Costs

Intervention would yield net monetary benefit of £10.6 million and net health benefit of 530 QALYs

Subcutaneous Implantable Defibrillators Cut Lead-Related Complications

Risk for major lead-related complications much lower with subcutaneous ICD versus transvenous ICD

Recent Cancer Treatment Linked to Worse COVID-19 Outcomes

However, a history of cancer more than one year before COVID-19 diagnosis not tied to increased mortality or hospitalization

Company Hid Problems With COVID-19 Vaccines From FDA

Nearly 400 million doses of vaccine made by Emergent had to be destroyed 'due to poor quality control'

Mailed At-Home Disposal Kits Up Opioid Disposal Rates

Mailed kits are a potential low-cost, scalable solution, the authors say

Hearing, Vision Impairment Up Odds of Cognitive Decline in Seniors

Odds of cognitive impairment increased more than eightfold for seniors with dual sensory impairment

Gut Dysbiosis Identified in Women With Recurrent UTI

Gut microbiome of women with a history of recurrent UTI depleted in microbial richness, butyrate-producing bacteria

Serious Neurologic Manifestations Tied to Worse COVID-19 Outcomes

Encephalopathy was the most common serious neurologic manifestation, occurring in 10.2 percent of adults hospitalized with COVID-19

PFAS, Phthalate Biomarkers Linked to Bone Mineral Density in Teens

Each doubling of serum perfluorooctanoate, overall PFAS/phthalate mixture linked to lower areal BMD in male adolescents

Hypertensive Disorders of Pregnancy Tied to Increased CVD Risk Later in Life

Established CVD risk factors account for 57 and 84 percent of the increased rate of CVD for preeclampsia, gestational HTN

Medicare Policy Changes Tied to Drop in Hospice Use for Dementia

Immediate and lasting reductions seen in the share of patients receiving hospice care with Alzheimer disease, related dementia code

Stronger School Lunch Standards May Help Cut Child Obesity

Change in BMI trajectory observed for low-income elementary students following implementation of the Healthy, Hunger-Free Kids Act of 2010

Colonoscopy Before Age 50 May Cut Colorectal Cancer Risk in Women

Reduced risk seen with earlier initiation of endoscopy, including lower risk for colorectal cancer diagnosed in women before 55 years of age

New-Onset Depression Common During Surgical Internship Year

Among surgical interns with no depression at baseline, 32 percent had high enough scores on mood surveys to be considered depressed

CDC Investigating 109 Cases of Severe Hepatitis Among Children

Majority of patients, who were otherwise healthy, recovered fully from their illness

COVID-19 Drug Paxlovid Might Also Fight Long COVID

Series of case reports shows some success with Paxlovid in treating patients with long COVID

Virus Found in Pig Heart Transplanted Into Man Who Later Died

Patient had been recovering fairly well from the transplant but then developed symptoms similar to an infection

2010 to 2017 Saw Increase in Uterine Cancer Mortality Rates

Mortality rates increased 1.8 percent for uterine cancer overall, 2.7 percent for nonendometrioid carcinoma

Rate of Major Complications Low With Living Donor Nephrectomy

Incidence of major complications after hand-assisted laparoscopic living donor nephrectomy low at 2.5 percent

Incidence, Mortality of Subsequent Primary Cancers Up for AYA Survivors

Five-year survivors of adolescent and young adult cancers at higher risk for developing, dying from a new primary cancer

2008 to 2017 Saw Payment, Geographical Shifts in Gender-Affirming Surgery

Findings coincided with state and federal policy changes favorable to gender-affirming surgery

Alcohol Use Disorder Deaths Up During the Pandemic

Greatest increases seen among younger persons aged 25 to 44 years

Use of Proton Beam Therapy for Newly Diagnosed Cancer on the Rise

Uptake of proton beam therapy for cancer treatment varies by clinical indication

FDA Limits Use of J&J COVID-19 Vaccine Due to Blood Clot Risk

With safer two-dose vaccines such as Pfizer and Moderna widely available, the one-dose J&J shot should be limited

Rotating Night Shifts May Hamper Healthy Aging

Findings seen in large sample of U.S. female nurses followed for 24 years

Orteronel Misses Goal in Metastatic Hormone-Sensitive Prostate Cancer

Significant improvement seen in progression-free survival, but not overall survival, with addition of orteronel to androgen deprivation therapy

Physicians Accept Remote Auscultation Alternative for Quarantined Patients

Remote digital auscultation of heart and lungs acceptable alternative to standard physical examination for COVID-19 patients in quarantine wards

AI Model Predicts Response to Spinal Cord Stimulation for Chronic Pain

Combined unsupervised (clustering), supervised (classification) machine learning technique used to develop predictive model

Asthma in Adults May Raise Risk for Subsequent Obesity

Higher risk seen for those with nonatopic disease, longer disease duration, as well as those taking oral corticosteroids

Treatment, Outcomes for AMI Patients Compared in Six Countries

Proportion of patients admitted with STEMI who received PCI in hospital in 2017 ranged from 36.9 percent in England to 78.6 percent in Canada

30.0 Million People of All Ages Uninsured in U.S. in 2021

For adults aged 18 to 64 years, 13.5 percent were uninsured, 21.7 percent had public coverage, 66.6 percent had private coverage

Women, People of Color Wait Longer to See ED Doctor for Chest Pain

Among young adults presenting to ED with chest pain, men were seen more quickly and were more likely to be admitted

HTN Not Detected Earlier With Self-Monitoring of BP in Pregnancy

Second study shows no improvement in mean systolic BP with self-monitoring versus usual care for chronic or gestational HTN

Only One in Five Parents Plan to Get COVID-19 Vaccine for Children Under 5 When Available

27 percent said they would 'definitely not' get their child vaccinated, 11 percent said they would do so only if required

Children's Mental Health Impacted by Adult COVID-19 Vaccination Rates

Stress surrounding the pandemic declined in U.S. children after vaccinations were rolled out for adults

Hospital Costs for Firearm Injuries Vary Widely by Region

Hospital costs for firearm injuries in the United States totaled $7.8 billion over 10 years; government insurance programs covered 42 percent of the costs

Medication Errors Reported Frequently by Home Care Service Nurses

Increased odds of not making medication-related errors found for nurses who had attended training within last two years versus longer period

Polygenic Risk Score for OA Predicts Risk for Hip, Knee Replacement

Participants with high PRS had increased risk for joint replacement; stronger association seen with hip replacement for women versus men

Factors ID'd for Failure of Nonoperative Treatment of Pediatric Appendicitis

Higher patient-reported pain level at presentation linked to increased risk for in-hospital treatment failure

Hypersensitivity Reactions to Gadolinium-Based Contrast Agents Studied

History of HSR to iodinated contrast media linked to increased risk for HSR to gadolinium-based contrast agent

Three More Children Have Died of Mysterious Liver Disease

Nearly 170 children in 11 countries have been diagnosed with acute hepatitis in recent months

Sun Protection Misinformation Still Common

Yet, six in 10 U.S. adults give themselves high marks for sun protection

FDA Warns of Counterfeit Home COVID-19 Test Kits

Two fakes the FDA knows of are counterfeit Flowflex COVID-19 test kits and iHealth Antigen Rapid Test Kits

Decrease in Youth Smoking Menthol Cigarettes After Cigarette Ban

Decrease in percentage of youth smokers who reported smoking menthol cigarettes from February to August 2020 in England

Response to CAR-T Cell Therapy Similar for Minority Patients

Progression-free and overall survival similar for minority, nonminority patients receiving CAR-T cell therapy for non-Hodgkin lymphoma

Assessment Scale Scores That Identify Light Sedation Examined

Scores best linked to ability to follow at least three commands were 4 on Sedation-Agitation Scale, −1 on Richmond Agitation-Sedation Scale

Effect of HF-Spinal Cord Stimulation on Chronic Pain Varies by Sex

Sex-specific differences observed for efficacy of high-frequency, low-frequency spinal cord stimulation for chronic pain

Male Urinary Symptoms May Indicate Mortality Risk Over Time

Findings for severity of symptoms such as incontinence and frequent nighttime urination, regardless of bothersomeness

Fatty Tissue Transfer Benefits Arthritic Finger Joints

Minimally invasive procedure associated with significant improvements of osteoarthritis symptoms

Opioid Mortality Rates Up for American Indian/Alaska Natives

1999 to 2019 saw increase in mortality rates for opioid-only and opioids in combination with other substances

Emphysema on CT Linked to Increased Risk for Lung Cancer

Pooled odds ratios for lung cancer increased with emphysema severity, and were higher for visual versus quantitative assessments on chest CT

Statistical Shape Modeling of US Images Predicts Hip Dysplasia in Infants

Statistical shape modeling of ultrasound images of stable dysplastic hips in infants predicts which hips will develop to normal, remain dysplastic

1.3 Million Smokers May Quit if U.S. Bans Menthol Cigarettes

Findings based on the impact seen following Canada's ban

Affirmative Action Bans Cut Percent of Underrepresented Med Students

Percentage of students from underrepresented racial and ethnic groups reduced with state affirmative action bans

Almost 30 Percent of COVID-19 Patients Develop 'Long COVID'

Factors independently associated with PASC include hospitalization for COVID-19, having diabetes, and higher BMI

AYA Solid Organ Recipients Need Support After Transfer to Adult Care

Successful retention in adult health care linked to more improved clinical outcomes, but decreases in appointment attendance seen over time

AI Tool May Help Predict Risk for Pancreatic Ductal Adenocarcinoma

Model uses features in computed tomography scans of the abdomen to help identify those at high risk for developing PDAC

Black, Hispanic Race/Ethnicity Linked to Intraoperative Occult Hypoxemia

Prevalence of intraoperative occult hypoxemia in 92 to 100 percent Spo₂ range higher in Black and Hispanic versus White patients

Artificial Intelligence Cuts Miss Rate for Colonoscopies

Adenoma miss rate drops by half for both proximal and distal colon lesions

Alabama Cases of Acute Hepatitis in Children Show Link to Viruses: CDC

Three of the nine patients in Alabama were so ill that they developed liver failure, and two needed liver transplants

New Omicron Subvariant Causing COVID-19 Spike in South Africa

Number of daily cases reported by the country has shot up from just a few hundred a few weeks ago to just over 6,000

Racial Differences Seen for Use of Proton Beam Therapy

Disparities greatest most recently and for cancers for which PBT is the recommended radiation therapy modality

Hypertensive Disorders of Pregnancy Prevalence Up From 2017 to 2019

Prevalence of pregnancy-associated hypertension and chronic hypertension increased among delivery hospitalizations

Sexual Minority Students Perceive Medical School Less Favorably

Bisexual, lesbian, or gay students have less favorable perceptions of the medical school learning environment, are more likely to report burnout

Migraine May Raise Risk for Burning Mouth Syndrome

Burning mouth syndrome is characterized by an intraoral burning sensation without a known cause

Link Between GI Issues, Internalizing Symptoms Studied in Autism

Best-fitting model in path analysis suggests bidirectional relationship between GI issues, internalizing symptoms in children with ASD

Dapagliflozin Well Tolerated in COVID-19 Patients, Regardless of eGFR

Effects of dapagliflozin on primary and secondary outcomes consistent for those with eGFR <60 and ≥60 mL/min per 1.73 m²

Racial Differences Seen for Joint Replacement Care and Outcomes

Differences seen across the continuum of care for knee, hip total joint arthroplasty for osteoarthritis

FDA Proposes Ban on Menthol Cigarettes, Flavored Cigars

Research has shown that menthol cigarettes are harder to quit than traditional tobacco products

Moderna Asks FDA to Authorize Its COVID-19 Vaccine for Children Under 6

Preliminary analysis indicates vaccine efficacy of 51 percent among children younger than 2 years and 37 percent among children 2 to 5 years

E.U. Says Europe Out of 'Emergency' Phase of Pandemic

Announcement is not binding and national governments within the European Union will still be able to set their own public health policies

Medicare Advantage Plans Often Deny Coverage for Eligible, Necessary Care: Report

About 28 million older Americans have Medicare Advantage plans

Having MS May Impact Cancer Screening, Diagnosis

Patients with multiple sclerosis and breast cancer less likely to have screen-detected breast cancer

Hospital Outcomes Worse With Suboptimal Treatment of Hypothyroidism

Patients with clinical hypothyroidism and a high prehospitalization TSH level had longer length of stay, increased risk for readmission

Vaccination Cuts Severe COVID-19 Risk in Heart Transplant Patients

COVID-19 vaccination is not associated with heart transplant-specific adverse events

Consider COVID Vax History When Assessing Adenopathy on Mammo

Axillary lymphadenopathy more likely within 14 days after vaccination; persistent axillary lymphadenopathy seen up to 43 weeks later

Weight Loss and Lifestyle Program Cuts Severity of Sleep Apnea

Change in apnea-hypopnea index greater for men receiving eight-week weight loss and lifestyle intervention in addition to usual care

Successful Intubations Up With Nasal High-Flow Therapy in Neonates

Higher rate of successful intubation on the first try, without physiological instability in the infant, seen with use of nasal high-flow therapy

Pfizer Seeks FDA Approval of COVID-19 Boosters for Children Ages 5 to 11

Initial two-dose series of the Pfizer vaccine was authorized for that age group in October

Surgery No Better for Wrist Fracture in Older Adults

Surgical treatment not superior to nonsurgical treatment for patient-rated wrist function at 24 months in adults aged 60 years and older

Providers, Patients Differ in Satisfaction With Anesthesia for Eye Surgery

Provider satisfaction is not a good predictor of patient satisfaction with anesthesia during ocular surgery

Antibiotic Use in Under 2s May Reduce Antibody Response to Vaccines

Possible negative association of history of antibiotic prescriptions with vaccine-induced immunity seen in young children

Racial Disparity Seen in Use of Epidural Blood Patches for Postdural Headaches

White patients more likely than Black, Hispanic, other race patients to receive patch sooner

Myocarditis, Pericarditis Risk Highest After Second COVID-19 Vaccine Dose

In large cohort, there were 5.55 excess events per 100,000 vaccinees after BNT162b2 and 18.39 after mRNA-1273

Food Insecurity Tied to Delayed, Forgone Medical Care

Food insecurity during the pandemic disproportionately affected non-White and low-income individuals

Risk for Guillain-Barré Syndrome Up After Ad.26.COV2.S Vaccination

Adjusted rate ratio of 20.56 found in head-to-head comparison of Ad.26.COV2.S with mRNA COVID-19 vaccines

Systemic Corticosteroids Tied to Vaso-Occlusive Episodes in Sickle Cell

Association seen among children and adults with sickle cell disease; association lower for those exposed to hydroxyurea

Continued Monitoring Needed for Anti-VEGF Therapy in Macular Edema

Substantial improvement observed through month 12, which persisted through month 60, but lessened with fewer treatments

Amputation Risk Up for Black, Rural Residents With Diabetic Foot Ulcers

Risk for major leg amputation or death increased compared with overall cohort of adult Medicare patients hospitalized with diabetic foot ulcers

Asthma, Atopy Risks Up in Offspring Born Via Infertility Treatment

Long-term follow-up of children shows increased asthma/allergy risk, independent of parental history of asthma and atopy

American Association for Cancer Research, April 8-13

The American Association for Cancer Research Annual Meeting

WHO Says Acute Hepatitis Cases in Children Now Reported in 11 Countries

Among 169 reported cases, at least one child has died; 17 children needed liver transplants

No Increased Risk for Appendicitis Reported With mRNA COVID-19 Vaccination

Findings from nationwide study in Denmark show no increased risk in association with vaccination or SARS-CoV-2 infection

Direct Provider Feedback Cuts Emergency Department Opioid Rx Rates

Intervention includes personalized feedback to clinicians and an electronic dashboard for peer comparison

Living Guideline Updated for Drug Treatment of COVID-19

Tenth version recommends nirmatrelvir/ritonavir in patients with confirmed COVID-19 who have highest risk for hospitalization

Vaccination Coverage in Kindergarteners Dropped in 2020 to 2021

3.9 percent of kindergarteners who did not have vaccine exemptions were not up to date for MMR in 2020 to 2021

Endoscopic Drainage Better for Necrotizing Pancreatitis

Rate of fistula formation and mortality lower with endoscopic drainage versus other surgical drainage methods

Vitamin D Level, Race/Ethnicity Tied to Breast Cancer Risk

Sufficient circulating vitamin D concentration linked to lower risk for breast cancer in Hispanic/Latina women

Pelvic Fixation May Not Be Needed With Cerebral Palsy Scoliosis

Indications ID'd for excluding the pelvis in children with CP scoliosis treated with growth-friendly implants

Patient-Reported Outcomes + Wearable Data Predict Postop Adverse Events

Findings seen among women with gynecologic cancers followed for four weeks

Male Teens With Sickle Cell Disease Unaware of Related Fertility Issues

Authors say educational materials and fertility testing options are needed

Drug Interaction Checkers Could Have Caught Adverse Events

More than three-quarters of COVID-19-associated drug-drug interactions could have been identified

Philadelphia Lifts Indoor Mask Mandate Enacted Four Days Ago

City's Board of Health voted during a Thursday night meeting to rescind the mandate

Adding Tislelizumab to Chemo Slows Advanced Nasopharyngeal Cancer

Progression-free survival prolonged with tislelizumab + chemotherapy versus chemotherapy alone in recurrent/metastatic NPC

Guideline Issued for Preventing SSI After Major Extremity Trauma

AAOS developed 14 strong and moderate-strength recommendations to decrease surgical site infections after major extremity trauma

Development of a Clinical Polygenic Risk Score Assay Described

Physician- and patient-oriented informational materials developed to support decision-making about polygenic risk scores

NSAIDs May Interfere With Efficacy of Bisphosphonates

No reduction in osteoporotic fracture risk seen among women receiving concomitant clodronate and NSAIDs

Guidelines Updated for Barrett Esophagus Diagnosis, Management

Guideline revised to synthesize current best practices in the management of Barrett esophagus

Inhaled Nitric Oxide Tied to Improved P/F Ratio in COVID-19 With ARDS

Improvement in mean P/F ratio with no reported toxicity observed among patients hospitalized with COVID-19 and mild-to-moderate ARDS

Mitapivat Superior to Placebo for Pyruvate Kinase Deficiency

Early, sustained, clinically significant hemoglobin response seen in 40 percent of patients receiving mitapivat versus none in the placebo group

Upper Airway Stimulation Effective in Teens With Down Syndrome, OSA

73.2 percent of patients had AHI of less than 10 events/hour at 12 months; improvement also seen in quality of life

COVID-19-Linked Hospitalization Up for Children During Omicron

87 percent of 397 children hospitalized during omicron predominance unvaccinated; 34 percent of unvaccinated children were Black

Medical Financial Hardship Tied to Higher Mortality in Cancer Survivors

Health insurance coverage played critical role in this association for adults aged 64 years and younger

Sharp Spike Seen in Air Pollution Levels in Recent Years

A climate change-driven increase in wildfires may be one of the reasons for the worsening air pollution nationwide

Opioid-Related Deaths on the Rise in Ontario, Canada

A shift in the age distribution of opioid-related mortality has occurred with the highest rates now observed in younger individuals

AACR: Novel COVID-19 Vaccine Aimed at Immunocompromised Patients

CoVac-1, a peptide vaccine, induces T-cell immune responses in those with B-cell deficiencies, particularly leukemia and lymphoma patients

Sex Hormone Deficiency May Up Risk for Rotator Cuff Repair

Odds of rotator cuff repair increased for women with estrogen deficiency and for men with testosterone deficiency

Ivosidenib + Azacitidine Ups Event-Free Survival in IDH1-Mutated AML

Event-free survival significantly longer compared with placebo and azacitidine for newly diagnosed IDH1-mutated AML

Early Effectiveness Assessed for Fourth Dose of BNT162b2 Vaccine

Difference in absolute risk for three versus four doses was 180.1 and 68.8 cases per 100,000 for COVID-19-related hospitalization, severe COVID-19

Non-O Blood Type Time-Dependent Predictor of VTE in Cancer

In patients with intermediate or low thrombotic risk tumor types, non-O blood type linked to increased VTE risk

Many Medicare Beneficiaries Do Not Fill High-Price Prescriptions

Among beneficiaries without low-income subsidy, noninitiation reported in 30 percent of those with new prescriptions for anticancer drugs

Adherence to Mediterranean-Style Diet May Cut Preeclampsia Risk

Odds of preeclampsia lower with greatest level of adherence to Mediterranean-style diet; similar benefit observed for Black women

Awake Prone Positioning No Benefit for COVID-19-Linked Hypoxemia

Evidence shows worse clinical outcomes on day 5 for the intervention group versus the usual-care group

More Than One in Seven Have a Headache on Any Given Day

New review shows headache disorders are a global burden

Weight Loss Surgery Effective Regardless of Age of Teens

Patient age should not be a barrier to weight loss surgery

Major Airlines Drop Mask Mandate After Federal Judge Rules Against It

U.S. Transportation Security Administration will stop enforcing the mandate for now

Transgender, Gender-Questioning Teens Have Worse Health Outcomes

On most measures in five domains of health, transgender adolescents reported differences from cisgender adolescents

Role of Race in Calculating UTI Risk in Children Reassessed

Race as a variable in risk prediction model can be replaced by history of UTI and duration of fever without affecting accuracy

Conjunctival Swab Positivity 12.7 Percent for SARS-CoV-2 Patients

Among hospitalized patients with SARS-CoV-2, eyes with CS positivity had significantly higher conjunctival redness grade

Role of Molecular Factors in BMI, Endometrial Cancer Link Studied

Evidence of mediating role seen for fasting insulin, bioavailable testosterone, and sex-hormone binding globulin

Psychological Factors Determine Poor Prognostic Outcome in IBD

Increased rates of glucocorticoid prescription or flare, escalation, death for those with clinical activity, symptoms of a common mental disorder

Achieving Treatment Goals in T2DM Can Up Life Expectancy

Life expectancy gains seen with reducing HbA1c, SBP, LDL-C, and BMI among individuals with type 2 diabetes

Use of Extrapolation Common in FDA New Drug Approvals

Extrapolation of the findings from pivotal clinical trials to the approved indication most common for disease severity

Cardiovascular Mortality Down Among Dialysis Patients

Greater declines seen for myocardial infarction, stroke, and pulmonary embolism among dialysis patients than general population

Acetaminophen Label Changes Not Linked to Accidental OD Admission

Monthly rates of hospital admission for accidental acetaminophen overdose unchanged over study period

PDE5 Inhibitors Prescribed for Men on Oral Nitrates for IHD

Among men with ischemic heart disease, coprescription of nitrates and PDE5 inhibitors not linked to increased risk for cardiovascular events

Parathyroidectomy No Better for Mild Primary Hyperparathyroidism

No reduction seen in mortality or key morbidities, including CV events, cerebrovascular events, cancer, peripheral fractures, kidney stones

Vijoice Granted First Approval for Treatment of PROS

Real-world data show 27 percent of patients with PIK3CA-related overgrowth spectrum treated with Vijoice had radiological response at 24 weeks

Health Officials Investigate Mysterious Hepatitis Cases Among Children in U.S., U.K.

In Alabama, the state has reported nine cases of hepatitis in children aged 1 to 6 years since October 2021

Most Cancer Centers Do Not Disclose Payer-Specific Prices

Median drug price markups across centers ranged from 120 to 630 percent

Many Doctors Unaware of Benefits of E-Cigarettes for Quitting Smoking

Survey shows many doctors less likely to recommend e-cigarettes for people seeking to quit smoking

Adverse Effects Generally Mild After BNT162b2 mRNA Booster in Over 60s

Thirty percent of those aged 60 years or older receiving booster reported at least one AE; few sought medical attention

Health Supervision Discussed for Children With Down Syndrome

Guidance provided for counseling of pregnant women with prenatal diagnosis, care of the child from infancy through adolescence

Review Shows High Prevalence of Fatigue in Adults With IBD

Prevalence of fatigue varied based on definition of fatigue and disease status

Impact of Method for Assessing Occupational Pesticide Exposure Examined

Method for assessing occupational pesticide exposure seems not to influence risk estimates for prostate cancer, NHL, Parkinson disease

Blood Biomarkers May Help ID Primary CNS Lymphoma, High-Grade Glioma

Systemic inflammatory biomarkers may be useful in the differential diagnosis of primary central nervous system lymphoma, high-grade glioma

Local Interventions Can Reduce Opioid Rx After Urologic Surgery

A systematic review and meta-analysis show direct interventions have a greater impact on opioid prescribing than indirect interventions

Marketing of Shockwave Therapy for Erectile Dysfunction Raises Concerns

Techniques, costs, and provider credentials in biggest U.S. cities vary widely