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Recent studies support a genetic contribution to smoking cessation. A study examining twins reported that 40% to 60% of the differences in successful smoking cessation are genetic. Dopamine receptor activity also relates to smoking cessation. A study in 2007 found a decrease in dopamine receptor density and high dopamine levels correlated with poor ability to learn from errors. Unsuccessful smoking cessation in people with this genotype may relate to a genetic inability to learn from negative outcomes. As we learn more and more about genetic variants, we can tailor recommendations and treatments to the genetic information relevant to our patients. See the source note by Beals to read the details of the study.


Source: Beals J. Using genetics of smoking behavior to optimize selection of cessation techniques. Medscape genomic medicine: genomics in practice. Medscape Nurses. Available at Accessed July 16, 2010.


Submitted by: Robin E. Pattillo, PhD, RN, CNL, News Editor