Lippincott Nursing Pocket Card - March 2024

Acute Kidney Injury

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Acute Kidney Injury

Formerly known as acute renal failure, acute kidney injury (AKI) is a reversible rapid reduction in glomerular filtration rate (GFR) or kidney function, resulting in an increase in serum blood urea nitrogen (BUN), creatinine, and metabolic waste products (Okusa & Rosner, 2023). If left untreated, AKI can lead to reduced urine output, fluid retention, volume overload, and ultimately irreversible loss of kidney cells and nephrons leading to chronic kidney disease.

Definition (Kellum & Lameire, 2012)

The Kidney Disease: Improving Global Outcomes (KDIGO) organization defines AKI as any of the following:
  • Increase in serum creatinine (SCr) by greater than or equal to 0.3 mg/dL (25.6 µmol/L) within 48 hours
  • Increase in SCr greater than or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days
  • Urine volume less than 0.5 mL/kg/hour for 6 hours
 
Classifications of Acute Kidney Injury
(Lippincott Advisor, 2024)
  Prerenal Intrarenal
(Intinsic) 
Postrenal
Pathophysiology Decreased blood flow to kidneys (decreased renal perfusion) Structural injury that causes vessel constriction within the kidney Blockage along the urinary tract obstructing urine outflow from the kidney
Causes 
  • Absolute decrease in circulating volume (Banasik, 2022)
    • vomiting, diarrhea
    • hemorrhage
    • burns
    • dehydration
  • Relative decrease in circulating volume
    • Systemic vasodilation and hypotension caused by sepsis, anaphylaxis, anesthesia, drug overdose
    • Third spacing and edema
    • Decreased cardiac output
  • Coagulation defect
  • Leukemia, lymphoma
  • Renal calculi
  • Emboli
  • Prostate enlargement
  • Genetic anatomic narrowing
  • Intra-abdominal tumors
  • Urinary tract strictures
  • Kinked or obstructed indwelling urinary catheters
 

Contrast-induced AKI (CI-AKI) (Kellum & Lameire, 2012)

CI-AKI [which may also be referred to as contrast-induced nephropathy (CIN)] may occur in patients who receive iodinated radiocontrast for procedures. Patients should be screened for risk factors such as impaired renal function, advanced age, diabetes, hypertension, congestive heart failure, chronic kidney disease, volume depletion, hemodynamic instability, concurrent nephrotoxic medication use and use of large volume and/or high osmolality contrast agents. To minimize risk, consider these strategies:
  • Consider alternative methods of imaging studies that do not require the use of contrast.
  • Use low dose iso-osmolar or low-osmolar contrast medium through an intravenous (IV) route and the lowest dose possible.
  • Begin IV fluids (isotonic sodium chloride or sodium bicarbonate) at least one hour before administration of contrast media and continue for 3 to 6 hours after administration to achieve urine output greater than 150 mL/hour in 6 hours. For patients at increased risk of developing CI-AKI, do not rely on oral hydration alone.
  • Withhold potentially nephrotoxic medications prior to contrast administration.

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Signs and Symptoms

AKI may not produce signs or symptoms until other organs are affected (Dihn, 2020). Signs and symptoms depend on the cause or complications of AKI.
 

Potential Signs and Symptoms of AKI (Lippincott Advisor, 2024) 
Shortness of breath Tachycardia Arrhythmias           
Nausea Hypertension Muscle cramps
Vomiting Weakness Seizures
Edema (abdomen, extremities) Fatigue Oliguria or nonoliguria

Diagnosis (Lippincott Advisor, 2024)

Laboratory Tests
  • Electrolytes: sodium, potassium, calcium, chloride, phosphorus, bicarbonate
  • Blood glucose
  • Albumin
  • Blood urea nitrogen (BUN) and creatinine
  • pH to detect degree of acid-base imbalance
  • Urinalysis
  • Complete blood count
Imaging
  • Ultrasound of kidneys and perirenal structures – detects kidney tissue damage, kidney stones, urinary tract obstruction, or other abnormalities
  • Computed tomography (CT) scan
  • Renal angiography – examines the blood vessels 
Diagnostic Procedures
  • Electrocardiography (ECG) to assess for arrhythmias related to electrolyte imbalance
  • Kidney biopsy for AKI with no clear etiology; can test for malignancy, vasculitis, nephrotic syndrome and glomerular disease

Stages of Acute Kidney Injury

Stages of AKI
(Kellem & Lameire, 2012; Palevsky, 2023) 
Stage CLINICAL MANIFESTATIONS
1 Any of the following:
  • SCr increased 1.5 – 1.9 times baseline
  • SCr increased greater than or equal to 0.3 mg/dL (26.5 µmol/L)
  • Urine output reduced to less than 0.5 mL/kg/hour for 6 – 12 hours
 2  Any of the following:
  • SCr increased 2.0 – 2.9 times baseline
  • Urine output reduced to less than 0.5 mL/kg/hour for 12 hours or more
3 Any of the following:
  • SCr increased 3.0 times baseline
  • SCr increased greater than or equal to 4.0 mg/dL (353.6 µmol/L)
  • Urine output reduced to less than 0.3 mL/kg/hour for 24 hours or more
  • Anuria for 12 hours or more
  • Initiation of renal replacement therapy
  • In patients less than 18 years, decrease in estimated GFR to less than 35 mL/min per 1.73m2

Complications (Okusa & Rosner, 2023; Mishra et al., 2022)

The following complications require immediate renal replacement therapy RRT/hemodialysis.
  • Fluid overload resistant to medical therapy and causing cardiopulmonary compromise
  • Severe Hyperkalemia
    • For any serum potassium greater than 6.5 mEq/L
    • Hyperkalemia associated with cardiac arrhythmias or muscle weakness
    • Hyperkalemia greater than 5.5 mEq/L associated with tissue breakdown or significant gastrointestinal bleeding
  • Uremic complications uncontrolled with medical therapy such as pericarditis, seizure, or unexplained change in mental status
  • Severe metabolic acidosis (pH less than 7.1) uncontrolled with medical therapy
  • Acute poisoning with dialyzable poisons and toxins  (i.e., metformin, methanol, ethylene glycol)

Treatment

The goal of therapy is to prevent life-threatening complications and limit further damage to the kidneys (Dihn, 2020). Treatment of AKI is mainly supportive, to preserve volume homeostasis and correct biochemical abnormalities.
  • Treat the underlying cause.
    • Manage hypotension; administer vasopressor to improve renal perfusion and achieve hemodynamic targets
    • Correct volume depletion in patients with vomiting, diarrhea, hypotension, tachycardia, or oliguria
      • Avoid fluid therapy in patients with pulmonary edema or anuria.
      • Administer 1-3 liters crystalloids individualized to correct volume deficit, followed by maintenance isotonic fluids at 75 mL/hour for volume responsive patients.
    • Urology and/or interventional radiology consultation for patients with hydronephrosis due to urinary tract obstruction.
  • Prioritize glycemic control and nutritional support.
    • Target plasma glucose between 110 and 149 mg/dL.
    • Restrict salt intake.
    • Low potassium, low phosphate diet.
    • Recommend high-calorie diet; start enteral feeding as soon as possible to decrease risk of stress ulcer, gastrointestinal bleeding, or hemorrhage.
  • Administer medications.
    • All medications should be reviewed, and dose adjusted based on GFR.
    • Diuretics are recommended only to manage volume overload (i.e., 80-100 mg IV furosemide) in patients who are not anuric; unless the patient requires fluid overload management, diuretics are not recommended to treat AKI.
    • Vasodilators do not show improvement for AKI patients; dopamine, fenoldopam, and/or natriuretic peptides are not recommended as treatment to improve kidney function.
    • Replenish electrolytes and treat acid-base imbalance.
    • The following medications can worsen AKI. Discuss discontinuing these agents with the healthcare provider.
      • Nonsteroidal anti-inflammatory drugs (NSAIDs)
      • Angiotensin-converting enzyme (ACE) inhibitors
      • Angiotensin receptor blockers (ARBs)
      • Nephrotoxins (aminoglycoside antibiotics, piperacillin-tazobactam, amphotericin B, tenofovir, nephrotoxic chemotherapy)
  • Institute renal replacement therapy (RRT) as ordered.  
    • RRT is indicated immediately for life-threatening changes in fluid, electrolyte, and acid-base balance.
    • For patients with volume overload who have anuria for more than 24 hours, who fail to respond to diuretics, or whose response to diuretics is not enough to avoid worsening hypervolemia, RRT is also indicated.
    • Types:
      • Hemodialysis (intermittent) is recommended for patients that can tolerate a rapid removal of toxins.
      • Continuous renal replacement therapy (CRRT) is recommended for hemodynamically unstable patients.
      • Peritoneal dialysis is rarely used for AKI.
    • The recommended dialysate buffer solution is bicarbonate to correct acidosis, reduce lactate levels and improve hemodynamic stability.
    • Anticoagulant therapy is recommended to prevent clotting of the filter.
      • For intermittent RRT with low risk for bleeding, use unfractionated or low-molecular weight heparin.
      • For CRRT with bleeding risk, regional citrate anticoagulation is recommended; if citrate is contraindicated, use heparin.
      • If heparin-induced thrombocytopenia (HIT) develops, discontinue all heparin and use a direct thrombin inhibitor, or Factor Xa.
  • Surgery
    • Insertion of vascular access port as needed for dialysis.
      • Choice of access is uncuffed, non-tunneled catheter
      • Choice of vein in order of preference: right jugular vein, femoral vein, left jugular vein and subclavian vein
    • A nephrostomy tube or ureteral stent may be needed to relieve obstruction
    • Kidney transplant for ESRD

Nursing Interventions

  • Monitor vital signs including pulse oximetry.
  • Perform daily weights.
  • Insert an indwelling bladder catheter to monitor urine output.
  • Calculate intake and output each shift or more frequently in ICU.
  • Assess lung sounds.
  • Monitor level of consciousness and perform neurologic examination.
  • Assess for edema.
  • Keep head of bed elevated, unless contraindicated.
  • Administer IV fluids as ordered to patients with AKI due to prerenal factors such as dehydration.
  • Ensure fluid restriction and/or administer diuretics as ordered for patients with volume overload.
  • Maintain continuous cardiac monitoring; assess for rhythm changes that may signal hyperkalemia (bradycardia, peaked T waves).
  • Encourage a low sodium, low potassium diet.
References
Banasik, J. L. (2022). Pathophysiology (7th ed.). Elsevier - Evolve. https://pageburstls.elsevier.com/books/9780323825498
 
Dinh N. (2020). Acute kidney injury: Challenges and opportunities. The Nurse practitioner45(4), 48–54. https://doi.org/10.1097/01.NPR.0000657324.33611.12

Kellum, J. A. and Lameire, N. (2012, March). KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements, Volume 2, supplement 1https://kdigo.org/guidelines/acute-kidney-injury/

Lippincott Advisor (2024, January 28). Teaching about diseases and conditions: Kidney injury (acute). Lippincott Advisor. https://advisor.lww.com/lna/document.do?bid=31&did=1092377&searchTerm=acute%20kidney%20injury&hits=kidney,injury,acute,kidneys,acutely,injuries

Mishra, R. C., Sodhi, K., Prakash, K. C., Tyagi, N., Chanchalani, G., Annigeri, R. A., Govil, D., Savio, R. D., Subbarayan, B., Arora, N., Chatterjee, R., Chacko, J., Khasne, R. W., Chakravarthi, R. M., George, N., Ahmed, A., Javeri, Y., Chhallani, A. K., Khanikar, R. G., Margabandhu, S., … Gopal, P. (2022). ISCCM Guidelines on Acute Kidney Injury and Renal Replacement Therapy. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine26(Suppl 2), S13–S42. https://doi.org/10.5005/jp-journals-10071-24109

Okusa, M.D. & Rosner, M.H. (2023, November 7). Overview of the management of acute kidney injury (AKI) in adults. UpToDate. https://www.uptodate.com/contents/overview-of-the-management-of-acute-kidney-injury-aki-in-adults

Palevsky, P.M. (2023, January 31). Definition and staging criteria of acute kidney injury in adults. UpToDate. https://www.uptodate.com/contents/definition-and-staging-criteria-of-acute-kidney-injury-in-adults