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  1. Aschenbrenner, Diane S. MS, RN


* Denosumab has been approved under the trade name Xgeva for use in patients with metastasized cancer to help prevent bone-related events.


* Clinical trials found denosumab to be superior to zoledronic acid in delaying the onset of such events in patients with metastatic breast or prostate cancer.


* Serious adverse effects of denosumab include hypocalcemia and osteonecrosis of the jaw.