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  1. Aschenbrenner, Diane S. MS, RN


* Duloxetine (Cymbalta), an antidepressant, is now approved for the treatment of chronic musculoskeletal pain.


* The drug can have serious adverse effects, including liver damage, allergic reactions, pneumonia, and suicidal thoughts and behavior, but these are rare.


* Adverse effects more often seen are nausea, dry mouth, insomnia, drowsiness, constipation, fatigue, and dizziness.