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depression, major depressive disorder, pharmacogenetics



  1. Krauter, Roseanne R. BS, RN, FNP
  2. Cook, Sarah S. DNP, RN-CS


Depression is a chronic disease seen in many healthcare settings. Current pharmacological treatment options are successful in two-thirds of patients. One CYP450 enzyme, CYP2D6, is responsible for the metabolism of 30% of all drugs including many antidepressants. Phenotypes of metabolizer status affect antidepressant treatment outcomes and adverse drug reactions.