1. Nishihara, Yutaka PhD
  2. Kajiura, Takumi PhD
  3. Katsuhiro, Yokota
  4. Kobayashi, Hiroyoshi MD, PhD
  5. Okubo, Takashi MD, PhD


Comparative efficacy study data showed that skin preparations formulated with more than 0.5% chlorhexidine gluconate (CHG) in alcohol produced significant reductions in microbial populations at the inguinal, abdominal, and antecubital sites at each sample time (P < .05) relative to baseline, and there were no significant differences statistically, including persistent effects within 24 hours (P > .05). It would be reasonable to expect that a 1% CHG-ethanol skin preparation (with >0.5% GHC in alcohol) could be chosen in Japan that would perform well and have promising potential for catheter preparation/maintenance preparation with consideration for recommendation of the Centers for Disease Control and Prevention's guideline dssuei in 2011.