1. Ritti-Dias, Raphael Mendes PhD
  2. Li, Ji MS
  3. Hollabaugh, Kimberly M. MS
  4. Stoner, Julie A. PhD
  5. Montgomery, Polly S. MS
  6. Gardner, Andrew W. PhD


PURPOSE: To investigate the association between oxygen uptake (



O2) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD).


METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath



O2 was obtained to assess



O2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded.


RESULTS: Using univariate analyses, higher values of tau ([[tau]], ie, slowed



O2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age <=66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to



O2 kinetics. Using multiple regression procedures, the identified predictors of slowed



O2 kinetics were female gender (4.76 [95% CI: 1.49-8.03] seconds; P = .0049), non-Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age <=66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015).


CONCLUSIONS: In PAD patients, slowed



O2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment.