Infection control practices are at the forefront of education and compliance monitoring. A university-funded grant allowed faculty and instructional designers to create an experience that increased student awareness, application, and appreciation of infection-control concepts. Computer-based instruction modules are used to provide content, and students participate in a simulation that allows them to apply their newly learned skills in a realistic, immersive environment with a biosphere used to visually depict infectious spread. Student feedback suggests the usefulness of this methodology as a teaching strategy that reinforces evidence-based practice, critical thinking, and clinical judgments.