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Diabetes Prevention Program, Diabetes Prevention Study, genetic and environmental interactions, impaired glucose tolerance, type 2 diabetes mellitus



  1. Quinn, Laurie PhD, RN


Type 2 diabetes mellitus (DM), characterized by insulin resistance and a [beta]-cell secretory defect, appears to result from a number of gene and environmental interactions. There are marked differences in the phenotypic expression of type 2 DM with individuals exhibiting varying levels of insulin resistance and impairments in insulin secretion. Study results indicate that a number of healthy lifestyle behaviors, such as increased physical activity and reduced intake of dietary fat, are associated with decreased development of type 2 DM. This article explores the genetic and environmental factors associated with the development of type 2 DM along with the role of lifestyle modifications in the prevention of this disease.