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  1. Lookinland, Sandra PhD, RN
  2. Beckstrand, Renea L. PhD, RN, CCRN


The effectiveness and safety of hormone replacement therapy (HRT) have been studied since the 1980s. However, much of the available evidence was contradictory, and practitioners were uncertain how to counsel peri- and postmenopausal patients. In this article, recent evidence, both for and against use of HRT in peri- and postmenopausal patients, is compared to past studies with recommendations for practice.