1. Salcido, Richard "Sal" MD, EdD

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As described in this month's continuing medical education article on page 534, pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease with a unique clinical presentation manifesting in chronic nonhealing wounds with significant pain and loss of quality of life.1 Given the precarious clinical manifestations of PG and its ability to mimic a severe bacterial infection, necrotizing infections, granulomatous disease, vasculitis, primary or metastatic tumors, and even factitious ulceration, it has been called the great imitator and even the "great marauder."2

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Aside from being elusive and difficult to diagnose, PG can be incited, activated, or spread through a process of pathergy.3 Pathergy is a skin condition in which a minor trauma such as a bump or bruise leads to the development of skin lesions or ulcers that may be resistant to healing. It can also lead to ulcerations at the site of surgical incisions.4


Although PG is not common, it is an instructive model that we can use to gain a holistic view (viewing the whole as more than the sum of its parts) of a complicated disease process resulting in chronic wounds. Dermatologic changes can be the first sign of an underlying medical condition, and the skin can act as a window5 to a patient's general health, guiding practitioners to a diagnosis.6 Patients may already have a preexisting diagnosis and go on to develop skin changes as part of multisystem disease.7 Categorized among the inflammatory dermatoses, PG is one of those diseases that herald underlying multisystem diseases or even a recurring preexisting comorbid condition, including rheumatologic, gastrointestinal, renal, and endocrine-metabolic disorders; internal malignancy (paraneoplastic skin changes)8; and/or hematologic cancers.


Any inflammatory or immune response associated with a given disease entity may result in a skin ulceration at a distant site that is static or even migratory. In PG, there is a propensity for lower-extremity ulceration. However, upper extremities and in some cases the abdominal wall, breast tissue, and other distant sites develop ulceration separate from the primary site or disease process. The etiology, pathergy, or triggering event is often unknown and remains an exclusionary diagnosis. The final standard pathway, however, is chronic inflammation as a result of an immune response.


In the management of PG, the clinician must be mindful of the multisystem approach, as highlighted in the continuing medical education article. While the treatment armamentarium is significantly focused on controlling PG with systemic and topical anti-inflammatory drugs, immunosuppressives, and antibiotics, it is important to consider that these patients may already be on therapeutic regimens for inciting comorbid diseases that triggered the predilection or risk for PG in the first place. Therefore, an interprofessional team including a clinical pharmacologist and pain management specialist is essential to manage the potential drug-drug, drug-disease, and drug-age interactions for patient safety, treatment efficacy, and quality consideration for harm/benefit and intention to treat.


Partnering with the patient is the "sine qua non" of what the patient wants and needs. Patients with PG and its complications require a focused interprofessional rehabilitation plan that takes into account the entire life span.1 As we all know, "Medicine has added years to life, but rehabilitation adds life to years."8




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2. Ma G, Jones G, MacKay G. Pyoderma gangrenosum: a great marauder. Ann Plast Surg 2002;48(5):546-52. [Context Link]


3. Steenbrugge F, Raaijmaakers M, Caekebeke P, Van Landuyt K. Pyoderma gangrenosum following trauma of the knee: a case of pathergy and review of orthopaedic cases. Injury 2011;42(4):421-3. [Context Link]


4. Rapini RP, Bolognia JL, Jorizzo JL. Dermatology: 2-Volume Set. St Louis, MO: Mosby; 2007. [Context Link]


5. Salcido RS. Finding a window into the skin. Adv Skin Wound Care 2002;15(3):100. [Context Link]


6. Lamb RC. Skin manifestations of systemic disease. Medicine 2017;45(7):399-404. [Context Link]


7. Silva JA, Mesquita Kde C, Igreja AC, et al. Paraneoplastic cutaneous manifestations: concepts and updates. An Bras Dermatol 2013;88(1):9-22. [Context Link]


8. Vasudevan S. Multidisciplinary Management of Chronic Pain. New York, NY: Springer International Publishing; 2015. [Context Link]