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  1. Olson, Karin RN, PhD
  2. Rennie, Robert P. PhD
  3. Hanson, John MSc
  4. Ryan, Mary BScN
  5. Gilpin, Jean BScMLS
  6. Falsetti, Maria BScMLS
  7. Heffner, Thea BScMLS
  8. Gaudet, Shirley BScN, CIC


This study tested whether central venous catheter (CVC)-related sepsis could be reduced by removing a hypothesized reservoir for pathogens, the CVC exit site dressing. Seventy-eight individuals with cancer, stratified for gender (37 men and 41 women) and transplant status, with newly inserted CVCs were recruited and randomly assigned to receive either a gauze dressing or no dressing, once their catheter insertion site had healed (3 weeks). Because there was no difference in CVC-related septic episodes based on gender or transplant status, the stratification was not maintained for remaining analyses. Although there was no significant difference in CVC-related septic episodes (P = .28) or rehospitalization rates (P = .41) because of CVC-related sepsis between the dressing and no-dressing group, individuals in the dressing group developed CVC-related sepsis sooner (P = .02) than did individuals in the no-dressing group.