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Brugada electrocardiogram, elderly, sudden cardiac death, women



  1. Yeh, Sherri Shih-Fan MD
  2. Chen, Ching-Yu Julius MD
  3. Wu, I-Chien MD, PhD
  4. Hsu, Chih-Cheng MD, PhD
  5. Chen, Tzu-Yu PhD
  6. Tseng, Wei-Ting PhD
  7. Tang, Feng-Cheng MD, PhD
  8. Wang, Chi-Chung MD, PhD
  9. Juan, Chung-Chou MD, PhD
  10. Chiu, Hou-Chang MD, PhD
  11. Lo, Huey-Ming MD, PhD
  12. Yang, Dun-Hui MD
  13. Juang, Jyh-Ming Jimmy MD, PhD
  14. Hsiung, Chao Agnes PhD


Background: Brugada syndrome is a disorder associated with sudden cardiac death and characterized by an abnormal electrocardiogram (ECG). Previous studies were predominantly conducted in men, and the data on long-term prognosis are limited. Information about women, especially elderly women, is lacking.


Objective: The aim of this study was to investigate the long-term prognosis of the Brugada ECG pattern in elderly women.


Method: We investigated the 10-year prognosis of the Brugada ECG pattern in elderly women in a nationwide community-based population in Taiwan. Community-dwelling women older than 55 years were prospectively recruited from December 2008 to March 2013 by a stratified random sampling method. All enrolled individuals were followed up annually until April 2019, and the cause of death was documented by citizen death records.


Results: Among 2597 women, 60 (2.31%) had a Brugada-type ECG, and this prevalence was higher than the mean global prevalence of 0.23%. One woman had a type 1 ECG (0.04%), whereas 15 (0.58%) and 44 (1.70%) women had type 2 and type 3 ECG patterns, respectively. Cox survival analysis revealed that all-cause mortality and cardiac mortality were similar in the individuals with and without a Brugada-type ECG during a mean follow-up of 96.1 +/- 20.5 months.


Conclusions: Our findings suggest that Brugada ECG patterns are not infrequent in elderly women but are not associated with increased risk of mortality in long-term follow-up; these findings may help reduce unnecessary anxiety for physicians, nurses, allied health caregivers, and patients.