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amniotic membrane, burn wound, donor site, petrolatum gauze, split-thickness skin graft, wound healing



  1. Vaheb, Mojtaba MD
  2. Kohestani, Bahareh Mohajer MD
  3. Karrabi, Maryam MD
  4. Khosrojerdi, Maryam MSc, RN
  5. Khajeh, Mahtab MD
  6. Shahrestanaki, Ehsan MSc
  7. Sahebkar, Mohammad MSc


OBJECTIVE: To evaluate the effect of amniotic membrane (AM) at split-thickness skin graft (STSG) donor sites.


METHODS: This double-blind randomized controlled trial was conducted on 35 eligible participants referred to the burn unit of Vasei Hospital of Sabzevar, Iran, during 2017 and 2018. Each STSG donor site was divided into two sides, and the respective halves were covered with either a dried AM or petrolatum gauze (control). Outcomes were evaluated on postprocedure days 10, 20, and 30 using the Vancouver Scar Scale.


RESULTS: The mean age of the patients was 39.4 +/- 13.97 years, and 62.8% (n = 22) were male. There was no statistically significant difference in wound healing rate on day 10 (P = .261), 20 (P = .214), or 30 (P = .187) between groups. The intervention group had significantly better epithelialization than the control group on day 10 (investigator 1, 1.62 +/- 0.59 vs 1.40 +/- 0.88 [P = .009); investigator 2, 1.22 +/- 0.84 vs 0.91 +/- 0.85 [P = .003]), as well as pain reduction (P < .001 during the follow-up period). However, there was no statistically significant difference between groups in terms of pigmentation or vascularization (P > .05).


CONCLUSIONS: Findings suggest that the use of AM is not superior to petrolatum gauze in terms of STSG healing rate; however, AM achieved better pain reduction and epithelialization on day 10.