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anesthetics, elastomeric pain relief pump, LA, LAST, local anesthetics, local anesthetic systemic toxicity, opioid alternatives, pain management



  1. Schneider, Melissa A. DNP, RN-BC, ONC, CNRN
  2. Howard, Katrina A. BSN, RN, NE-BC


Abstract: Local or regional anesthetics are becoming more common pain management options for patients, especially considering concerns regarding opioid use disorders. Though mostly safe, these interventions may carry serious risks such as local anesthetic systemic toxicity (LAST). This article discusses LAST and the importance of recognizing its signs and symptoms.