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The use of topical corticosteroids during pregnancy does not appear to be associated with infants being small for their gestational age or having low birth weight. In a propensity score-matched cohort study published online May 5 in JAMA Dermatology, researchers compared outcomes in 60,497 pregnancies in which the mother was exposed to topical corticosteroids to those in a matched cohort of 241,986 pregnancies with no corticosteroid exposure. There was no clinically significant increased risk of infants who were small for their gestational age or at low birth weight regardless of potency or amount of topical corticosteroid used. However, the researchers could not rule out a slight increased risk with potent to very potent topical corticosteroids in large amounts, though it is unlikely to be of clinical significance. The researchers note that residual confounding may have affected the results, as it was not possible to determine what underlying conditions were being treated with the corticosteroids, a factor that could affect the outcomes.