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  1. Aschenbrenner, Diane S. MS, APRN, BC


* The FDA now requires a black box warning on the labeling of all drugs containing propoxyphene stating that overdose with the mild opioid analgesic can be fatal.


* The warning also indicates that taking propoxyphene together with strong CYP3A4 inhibitors may enhance propoxyphene plasma levels.


* A medication guide has been developed to alert patients to the hazards of propoxyphene overdosing and other adverse effects of the drug.