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  1. Pierce, Janet D. PhD, APRN, CCRN, FAAN
  2. Shen, Qiuhua PhD, APRN, RN
  3. Thimmesch, Amanda BA


There is still much debate over the optimal fluid to use for resuscitation. Different studies have indicated either crystalloid or colloid is the ideal intravenous solution to administer, based on mortality or various physiological parameters. Older studies found differences between crystalloids and colloids. However, with the evolving science of fluid administration, more recent studies have shown no differences in patient outcomes. This review article will provide an overview of these substances and discuss the advantages, disadvantages, and implications for giving crystalloids and colloids in clinical practice.