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keloid, platelet-rich plasma, superficial photon X-ray radiation, surgical incision



  1. Jones, Michael E. MD
  2. Hardy, Cherrell BSN, RN
  3. Ridgway, Julie BSN, RN


OBJECTIVE: The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment.


DESIGN: Retrospective.


SETTING: Plastic surgery office-based outpatient setting in New York City.


PATIENTS: Forty patients with 44 keloid scars requiring surgical excision.


INTERVENTIONS: Keloid scars were treated using surgical excision, platelet-rich plasma, and postoperative in-office superficial photon X-ray radiation therapy. Intralesional triamcinolone injections were administered once to 4 patients with poor results on scar scale assessment. Patient follow-up visits ranged from 3 to 11 months to assess for evidence of recurrence and adverse effects.


MAIN OUTCOME MEASURE(S): For the purpose of this study, recurrence was defined as any sign of extraordinary erythema, induration, and hypertrophy beyond the site of excision.


MAIN RESULTS: In the 16 keloids treated with 2 fractions, there was no evidence of recurrence. One of 25 keloids treated with 3 fractions demonstrated evidence of recurrence. One of 3 keloids treated with a single fraction displayed signs of recurrence. Postirradiation hyperpigmentation was noted in all patients.


CONCLUSIONS: Surgical excision combined with platelet-rich plasma and postoperative in-office superficial radiation therapy achieved a 95.5% nonrecurrence rate at 1- to 3-month follow-up. This protocol appears to be a safe and viable option in the management of keloids and merits further randomized controlled study of its comparative efficacy.