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culture of safety, medication safety, nursing, nursing care, nursing history, patient safety



  1. Kowalski, Sonya L. MSN, RN, ACNS-BC
  2. Anthony, Maureen PhD, RN


Background: In its 1999 report To Err Is Human: Building a Safer Health System, the Institute of Medicine (IOM) suggested that between 44,000 and 98,000 Americans die annually as a result of medical errors. The report urged health care institutions to break the silence surrounding such errors and to implement changes that would promote a culture of safety.


Objective: Our aim in conducting this content analysis of AJN articles was to explore the nurse's historical and contemporary role in promoting patient safety. We chose to focus on AJN because, as the oldest continuously published nursing journal, it provided a unique opportunity for us to view trends in nursing practice over more than 100 years.


Methods: We reviewed all AJN tables of contents from 1900 through 2015, identifying for inclusion articles with titles that suggested a focus on nursing care, patient safety, or clinical content. We then read and analyzed each of the final 1,086 articles over a period of nine months.


Findings: Our content analysis indicates that the early articles (from 1900 through 1920) focused on such safety measures as asepsis and the newly understood germ theory. In the 1930s, articles proposed methods for preventing medication errors and encouraged the development of written procedures to standardize care. During World War II, nurse authors identified improved patient survival rates with the use of "shock wards" and recovery rooms. The 1950s saw the emergence of progressive patient care initiatives, through which patients were assigned to various levels of care (intensive, intermediate, self, long-term, or home care) based on patient acuity. The 1960s brought increasingly complex equipment and medication regimens, which created safety problems. Hospital-acquired infections were recognized. Unit-dose medication was instituted in the 1970s. In the next two decades, medication and nursing-procedure safety were emphasized. From 2000 to 2015, articles looked beyond human performance as causes of health care errors to systemic factors, such as poor communication, patient-nurse ratios, provider skill mix, disruptive or inappropriate provider behavior, shift work, and long working hours.


Conclusions: Emphasis on patient safety increased as patient care became more complex. As nurses developed a professional identity, they often put a spotlight on safety concerns and solutions. The IOM report, which encouraged research focused on systemic solutions to errors, was instrumental in furthering the very culture of safety that the nursing profession had championed.


Article Content

In response to research suggesting that 44,000 to 98,000 U.S. patients die each year as a result of medical errors, the Institute of Medicine (IOM) recognized a need for comprehensive health care delivery reform.1 Its 1999 report To Err Is Human: Building a Safer Health System provided the impetus for breaking the silence surrounding health care errors in order to ensure that safety is built into the processes of care.1 This report was followed in 2004 by the Joint Commission's National Patient Safety Goals,2 and a year after that by the Quality and Safety Education for Nurses initiative.3 Because the IOM estimate of annual deaths resulting from medical errors was based on data collected between 1984 and 1992, James sought to provide an update in 2013.4 Based on medical record evidence collected between 2002 and 2008 within broad hospital populations, and applying a different mode of analysis, James estimated that more than 400,000 premature deaths each year were attributable to preventable adverse events. There continues to be much debate about how best to define, measure, and prevent deaths due to medical errors.

Figure. All photos a... - Click to enlarge in new window All photos are from the

In order to explore the historical and contemporary role of the nurse in promoting patient safety, we performed a content analysis of 1,086 articles published in AJN from its inception in October 1900 through December 2015. We chose to focus on AJN because, as the oldest continuously published nursing journal, it provided a unique opportunity for us to view trends in nursing practice related to patient care and safety over more than 100 years.



We used the JSTOR database to access all issues of AJN from 1900 through 2007 and the Ovid database to access all issues from 2008 through 2015. We reviewed the table of contents in each issue, excluding feature articles with titles suggesting a nonclinical focus. We each independently read and analyzed articles with titles that suggested a clinical focus for patient safety content and met to compare notes, identifying trends, categories, and themes. This process continued for more than nine months. When all clinical articles published from 1900 through 2015 had been analyzed, the data were clustered into intervals of 10, 15, or 20 years, depending on the amount of data and the themes that emerged in each era.



1900-1919. From the earliest articles in this period, it is clear that nurses played an important role in patient safety. In 1908, an article by a physician on the duties of nurses in managing home-based surgeries emphasized sponge counts as a critically important nursing responsibility: "When the abdomen is about to be closed, she should count her sponges, and this should be done deliberately and several times in order that there be absolutely no question."5 Decubitus ulcers and hypostatic pneumonia were widely recognized as complications of prolonged bed rest, and the nurse's role in preventing these complications through frequent position changes was well documented. As an RN author explained in 1908, a nurse needed to have knowledge that went well beyond assessing and documenting vital signs6:

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1900-1919

"Not only must she be fully trained to care for patients who are doing well[horizontal ellipsis], but she must know the danger and complications likely to arise and be able to guard against them, and report the earliest symptoms of such changes, and should emergencies arise be able to do the right thing, at the right time, till the doctor arrives."


In this era preceding the discovery of antibiotics, safety in nursing care focused largely on the newly understood germ theory. Maintaining cleanliness and asepsis was critical in preventing contagion. A nurse writing in 1906 advised colleagues caring for a patient in a private home to hang a sheet over the door of the sick room. "This is done[horizontal ellipsis] to prevent any germs from following the draught outward when the door is opened."7 A physician author described the role of the nurse as follows8:


"She is taught to make her hands sterile whenever they are to come in contact with abraded surfaces so that infection by carelessness or ignorance may not be conveyed by her. She is also taught to prevent the spread of disease-bearing microbes from patients with diphtheria, scarlet fever, pneumonia, and the numerous avenues by which sickness may be conveyed from sick to well."


While prevention of contagion was a prevalent theme, the analysis of articles from these two decades revealed little about nursing practices concerning other aspects of patient safety. For example, the use of hot water bottles9-11 and restraints12, 13 were often discussed, with no mention of precautions to prevent injuries. In a 1910 article, a physician and nurse explained hydrotherapy, a practice commonly used to treat psychiatric ailments.14 The treatment required the patient to be immersed in bathwater, "without removal except for cleaning the tubs," for periods "varying from a day to two or three months."14 Water temperatures were generally kept at 98[degrees]F to 100[degrees]F. While the article described the physical properties of the tubs and rooms, there was no discussion of precautions to prevent accidental drowning or bacterial infection, or any explicit mention of the risk of scalding.


During this period, little was written about fall prevention. A physician who authored an article titled "Medical Gymnastics in Locomotor Ataxia" devoted only a single sentence to the subject, stating that "at all times" the patient should "be well guarded from falls and injury."15 As was typical in this era, an article on delirium described various manifestations of the condition and warned the reader that the patient might get out of bed and fall.12 Little of the article, however, was devoted to nursing care. The only advice the author offered the reader was to fasten the patient "under a restraining sheet."12


An alarming article published in 1909 described the "baking oven" used to treat rheumatism, nephritis, and pelvic congestion.16 The patient, wrapped in a blanket, was placed in the oven at temperatures of 200[degrees]F to 250[degrees]F for 45 minutes to an hour. The only safety precautions described were as follows: "A nurse remains with the patient, and the pulse is watched, but is not recorded unless so ordered. Stimulants are at hand in a nearby medicine closet."16


When analyzing these early writings, it is necessary to understand the prevailing conventions of the time. Most hospital units were open rooms in which all patients could be easily seen and attempts to get out of bed would be readily noticed. In addition, for the segment of the population that could afford it, much nursing care was delivered in the home by private duty nurses who cared for a single patient at a time, decreasing the risk of falls and accidental injury.


Because nurses were not yet recognized as independent professionals with expertise that was distinct from and complementary to that of physicians, many articles were written by physicians, who focused on pathophysiology and symptomatology rather than nursing care. References were rarely cited. Even the articles written by nurses failed to emphasize the role of the nurse in patient care. Furthermore, data on adverse outcomes were yet to be collected in an organized manner that could inform practice.


1920-1929. Over the next decade, articles continued to highlight knowledge and new technology, still tending to focus on its proper use and application rather than on the associated nursing care and safety precautions. An article introducing electrotherapy-a technology that used an electric current to treat a variety of conditions, including "constipation, paralysis,[horizontal ellipsis] a sluggish liver, a badly functionating [sic] kidney, or an inflamed appendix"-noted that the heat generated by the current could damage tissues, but did not discuss how to prevent injury.17 An article describing a heating apparatus for IV solutions discussed the advantages it offered both the patient and the nurse, but included no precautions.18 An article on applying hot surgical dressings, which were boiled for 30 minutes before being applied directly to a wound, failed to mention the possibility of burns.19 "A Simple Method of Procuring Blood for Diagnosis from Infants" not only neglected to describe safety measures to take when puncturing the anterior fontanel to sample blood from the sinus route, but denied that the procedure carried any risk of infection, perforation, or shock, stating, "The method is so simple that even an inexperienced operator does not hesitate to try it."20

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1920-1929

The field of psychiatric nursing was growing during this time and many articles focused on this emerging specialty area. "Nursing the Mental Patient" was typical in that it discussed the need for psychiatric nurses, as well as their desirable qualities (tact, diplomacy, and cheerfulness), but made little reference to patient safety other than to say, "A harsh word spoken in a moment of exasperation, or a thoughtless laugh in the presence of a sensitive patient, does incalculable injury."21 Private duty nursing was a common topic, but as with articles on hospital nursing, content focused on disease processes and symptoms rather than on patient care and safety.


Insulin, which would later be identified by the Joint Commission as a "high-alert" medication,22 was discovered as a lifesaving treatment for type 1 diabetes in 1921. The propensity of insulin to induce hypoglycemia was quickly recognized, and "The Treatment of Diabetes with the Aid of Insulin" advised nurses to teach patients about balancing food and insulin intake.23 After being admitted to the hospital, the author noted, the patient's "basal metabolism is determined and a diet calculated which will meet his caloric needs, afford him sufficient protein, and in which the proportion of fat to carbohydrates will not be unduly high."23 The article then discussed measures nurses could take to prevent hypoglycemia, including ensuring that insulin is not administered "too far in advance of the meal" and that the meal is "served on time," reducing the insulin dose if the patient is vomiting or has diarrhea, reporting to the physician if the patient doesn't eat the food served after insulin has been administered, and revisiting the patient's diet and dosage in the presence of weight changes.


Other signs that patient safety was moving to the forefront of nursing literature included the first mention of side rails in the January 1924 issue, which featured two photos of beds for "helpless patients."24 The November 1924 issue introduced the idea of a unit manual or "ward standard book."25 Although ensuring "patient safety" wasn't explicitly included in the book's stated purpose, it was implied, as the concept was said to have "evolved in connection with the movement for increased efficiency and standardization in hospital management, including care of patients."25 A 1926 article by Russell highlighted the American Hospital Association standards for hospital furniture and suggested the use of low beds (18 to 20 inches from the floor) for patients at risk for falling.26 A 1928 article on tonsillectomies advised nurses to add methylene blue to cocaine so that it would be distinguishable from Novocaine.27 The first article we found that was devoted entirely to safety was on the topic of preventing electrical accidents, such as shocks and fires.28 Unlike the 1910 article on hydrotherapy, a 1929 article on the same treatment included a section devoted to patient safety that advised such nursing actions as frequently checking the water temperature, never leaving the patient unattended, keeping the patient well hydrated, and lowering the water temperature if the patient has a fever.29


1930-1939. Many articles of the 1930s continued to neglect patient safety and often imparted erroneous information. An article on caring for an elderly patient with numerous conditions that predispose to injury (a fractured hip, emaciation, fragile skin, and frequent confusion) included no discussion of preventing falls or other injuries.30 The 1935 article "Analgesia in Obstetrics" urged the use of paraldehyde in childbirth to provide "the complete relief of suffering from the very onset of labor, throughout its entire course, and for several hours following delivery," claiming that the drug had been "definitely demonstrated" to have no "untoward effects upon either mother or baby,"31 a statement we now know to be untrue.

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1930-1939

This decade did, however, bring increased attention to the importance of medication administration safety. By 1933, drug administration errors were recognized as a big problem, and AJN published its first article on the subject.32 The author had surveyed 30 schools of nursing about the steps they required students to take in order to prevent errors when administering medication. The steps that received the most responses were to read the medication labels three times, use medication tickets to indicate doses, permit no interruptions while medications were being poured or administered, and identify patients by name before administering medication.32


A 1939 article suggested additional methods for preventing medication errors, such as exclusive use of either the metric or apothecary system-"and preferably the metric"-at all hospitals, consistent use of either trade names or "official" (generic) names or both; use of name cards on patient beds; exclusive use of white (not colored) medication cards; and use of a record (separate from the patient's medical record) for all medication orders on which nurses indicate administration of a drug with a check mark, a time stamp, and their signature in order to prevent double dosing.33 The nurse author pointed out that physicians' illegible handwriting and failure to cooperate with nurses who question unusual dosages are frequent contributors to medication errors.


The dangers inherent in insulin administration were covered in more detail than in the previous decade. In 1938, Taylor urged nurses to read insulin orders twice, have "a head nurse or supervisor check the vial of insulin and syringe containing the dosage," and "read with care the unit strength per cubic centimeter of the particular vial of insulin,[horizontal ellipsis] understand[ing] that U-20 represents 20 units of insulin per cubic centimeter and[horizontal ellipsis] that U-80 [is] insulin of four times greater strength."34 (In 1938, insulin was available in four strengths: U-20, U-40, U-80, and U-100.) An article on oxygen therapy discussed potential dangers related to the fact that it "very actively support[s] combustion" and, in high concentrations, may damage lung tissue, particularly when delivered in areas at or near sea level.35 The use of radium to treat various cancers had increased, and an article explaining the treatment discussed precautions that should be taken to protect both patients and health care providers.36 This decade also brought awareness of the role nurses play in recognizing digitalis toxicity37 and sulphanilamide toxicity.38


In 1939, the article "Safety in Hospitals" was devoted entirely to safety of both patients and hospital personnel.39 This one-page article discussed a wide range of potential dangers, including defective electric appliances, hospital furniture, and assistive devices; poor lighting; burns from hot water bottles and overheated electric pads; and slippery bathtubs. The author further maintained that it was necessary "to educate the hospital personnel to be safety-minded, by use of bulletin boards, posters[horizontal ellipsis] and meetings for discussing safety."39


1940-1949. In the 1940s nurses were active inventors of safety equipment and protocols, and AJN invited them to share their inventions with readers. Rich described an "inhalation screen" that protected small children from heat sources used in steam inhalation treatments, allowing the nurse to leave the child unrestrained and not requiring the nurse to keep constant watch at the bedside.40 Graves discussed policies and procedures pediatric nurses could employ to prevent falls, choking, smothering, burns, and medication errors.41 Martin analyzed the types of accidents that occurred most frequently in a children's hospital and developed a prevention program that included "clinics, conferences, and a class on accidents."42 Foot supports were used to promote proper alignment in pediatric patients with polio and patients using respirators, who were confined to bed rest for long periods. In a 1947 article, Irene described the materials required to make the foot supports and provided directions for assembly and use.43 McQuaid wrote about a new system nurses developed and implemented to "assure uniform, consistent use" of the card file system, thereby reducing errors in patient care and strengthening the effectiveness of the file.44 Hofmann and colleagues described what may have been the first specialty bed used in nursing practice: a sawdust bed designed to prevent pressure sores in emaciated and incontinent patients.45

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1940-1949

Nurses caring for World War II casualties recognized that patient survival required close observation and rapid intervention. As Setzler explained in a 1944 article, "Seconds count in the saving of lives of these men and just as rapidly are lives lost by delayed treatment."46 Equipment, personnel, and logistical needs along with priority procedures were detailed for rapid treatment in "shock wards." "Shock carts" were developed to transport needed equipment to the bedside to speed emergency care. In 1946, Welch recommended the medications and equipment that should stock the cart and where each of the items should be located.47 An increase in the number of patients having surgery and the obstacles to safe care when patients were returned immediately to the unit led to the creation of recovery rooms in hospitals throughout the country.48 Having a space, equipment, and staff dedicated to the care of postoperative patients improved both safety and efficiency. Nurses supported the use of postoperative recovery rooms to prevent "a stormy postoperative convalescence."49 Hurlburt and Oscadal credited the establishment of an obstetric recovery room with reducing deaths related to postpartum hemorrhage and shock.50


The war introduced new safety concerns, as nurses joined the military, leaving fewer available to care for patients at home. Richardson detailed the disaster plans implemented at a Connecticut hospital and the procedures developed for safely treating patients with explosion injuries, whose clothing may contain dangerous chemicals.51 The chief medical officer of the Office of Civilian Defense wrote about the expanded Volunteer Nurse's Aide Corps, the purpose of which was "to maintain professional nursing standards, conserve nursing resources, and safeguard the health of the people in this period of national peril."52 Nurses were cautioned that "in the handling of gas casualties,[horizontal ellipsis] to do the wrong thing may be more serious than to do nothing."53 For such patients, first responders were advised, "Do not attempt artificial respiration [as it] may do more harm than good, and even cause sudden death."53 In light of the nursing shortages, Barrett proposed that nurses simplify nursing procedures to increase patient safety, eliminating "from our nursing procedures those aspects which are nonessential to the patient's welfare and comfort."54 As nurse shortages continued after the war, nurses were encouraged to assess alternate staffing practices for safety55, 56 and to participate in hospital licensure to improve quality and safety of patient care.57


By the 1940s, fires had become a significant safety issue, with multiple hospital fires occurring daily. Ruth in 1946 and Pellenz in 1949 wrote about the role of nurses in fire prevention, fire control, and patient evacuation.58, 59 One in five of the fires were attributed to smoking and careless use of matches; other common causes included defective wiring, short circuits, misuse of electrical equipment, improper storage of combustible materials, and use of such therapeutic equipment as oxygen tents and heating pads.58 The 1949 fire at Saint Anthony's Hospital in Effingham, Illinois, which killed 74 people, occurred three months following publication of the Pellenz article. McCurdie and Livingstone described methods for preventing and controlling anesthesia explosions, such as eliminating high-static bedclothes in the operating rooms, testing the conductivity of shoes worn by all operating room personnel, and safely storing and transporting combustible materials.60, 61


1950-1959. Many 1950s articles emphasized rapid intervention for high-risk patients as a safety priority. As in the previous decade, they praised the lifesaving potential of well-staffed and well-stocked surgical recovery rooms,62, 63 as well as the Air Force "crash wards" and hospital annexes, which were located near landing fields in order to provide rapid treatment to accident victims.64 This decade introduced progressive patient care initiatives, through which, based on "their over-all medical and nursing needs," patients were assigned to intensive care, intermediate care, self-care, long-term care, or home care-each offering different services within different settings and with varying staffing patterns-but the only patient outcome discussed was patient satisfaction.65

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1950-1959

The 1950s saw a growing recognition that specialized care for premature infants could reduce the high mortality rates in this population. Losty and colleagues described the initiation of a New York City transport service developed to provide safe and rapid transportation of premature infants to centers with specially trained medical and nursing personnel.66 They described the planning; the necessary equipment; the responsibilities of the transport personnel; and the favorable responses of nurses, parents, and physicians. For nursing students completing their pediatric rotations, Latham promoted an educational program that emphasized safety for hospitalized children.67 The program provided care guidelines that addressed the different precautions nurses should take depending on the child's developmental stage.


In 1950, Press reported that "[n]ext to cardiovascular disease and cancer, accidents kill more people in our nation than any other cause" and urged nurses to promote accident prevention within hospitals, industrial sites, schools, and homes.68 Hospital accident prevention targets included patient falls, unsafe use of bed rails, hot water bottle burns, operating room fires and explosions, electrical equipment accidents, and radiation exposure.68-74 Safety information reprinted from other journals was also embedded within articles, such as a boxed advisory on sponge count procedures75 and a boxed declaration of X-ray safety.76


In 1953, Hall described patient information plates that could reduce transcription errors.77 The importance of positively identifying patients before administering any treatment or procedure, which had been discussed in the 1930s, was reinforced in this era.69, 78 Byrne urged nurses to ask patients to state their names before administering medication. Her study, however, found that "[i]n spite of the emphasis we placed on this factor, [there was] an increase in the number of errors."79 For medications seen as posing the greatest risks to patients-barbiturates, opioids, sedatives, weight loss medications, intramuscular injections, IV medications, and blood products-specific safety precautions were proposed, including establishing legal and procedural controls for dispensation, discriminate use, and proper technique in preparation and administration.80-86


Articles in the 1950s discussed psychiatric safety in greater detail than in the 1920s, promoting communication techniques that protected both patients and nurses and describing appropriate nurse-patient relationships.87-89 An AJN news item alerted nurses to a study of patients who had previously attempted suicide, which concluded that for those whose prior suicide attempts were considered "serious," certain psychiatric diagnoses, including manic-depressive disorder and dementia, were risk factors for future attempts and warranted patient hospitalization.90 Self-inflicted injury was identified as an uncommon but preventable hospital occurrence.73


In-service educational programs were provided for nurses in such specialty areas as neurology to increase patient safety and nurse satisfaction.91


Educational programs were used to help nurses "keep up with the continuous changes in nursing and related fields, to understand the policies, philosophy, and working environment of the particular organization or institution, and to provide better care to patients."92


1960-1969. With the increasing complexity of medication regimens and the introduction of such hospital equipment as adjustable beds and hydraulic lifts, the 1960s prompted more specific mentions of patient safety within nursing articles. Kaplan and Bernheim cautioned readers about the potential dangers associated with Sengstaken tubes used to treat bleeding esophageal varices.93

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1960-1969

In this period, fall prevention received more attention, though it was often still cursory in nature. For example, an article on postoperative ambulation had only a single sentence implying the risk of falls: "Elderly patients need additional assistance to prevent accidents and to help re-establish self-confidence."94 On the other hand, a literature review called "Why Old People Fall" summarized the physiologic reasons older adults are more likely to fall and included practical suggestions for preventing falls both in the hospital and in the home.95 Specifically, it suggested that nurses supervise or assist older patients with standing, ambulation, and power-building exercises; teach older patients that hyperextension of the neck can cause them to lose equilibrium; advise them not to sit up, stand up, or turn too quickly; teach them not to turn on the heel, but to walk in a small circle to make a turn; and instruct patients at discharge that they should remove scatter rugs from their home, avoid slippery floors and doorsills, keep their home well lit, and use assistive devices if necessary.95


An article on caring for patients with Meniere's disease suggested that these patients should have side rails on their beds, be advised not to get up and walk without assistance while hospitalized, keep an uncluttered home environment, and have a lamp at the bedside.96


Burns from hot water bottles were a common source of litigation in this decade. An AJN column of this period, The Law and the Nurse, warned nurses that they could be held liable for such injuries.97, 98


The 1960s brought an emerging understanding of the risks of hospital-acquired infections. Authors advocated against bladder catheterization for urinary incontinence99 and routine orders to catheterize postoperative patients.100 Suddarth recommended individual dressing packs to prevent wound infections, and Hall advocated for antibiotic stewardship to prevent microbial resistance.101, 102 Streeter and colleagues described a retrospective surveillance program that became a proactive, nurse-led infection control and prevention program.103


Despite these advances, the term "patient safety" was not specifically mentioned in the 1960-1962 American Nurses Association (ANA) platform.104 Articles about potentially dangerous treatments, such as home oxygen,105 or the care of patients with potentially dangerous conditions, such as alcoholism,106 suicidal ideation,107 and visual spatial neglect,108 continued to appear, though some were less solution-oriented than others, seeking to shed light on innovations or underrecognized conditions, rather than to focus specifically on safety precautions.


1970-1979. The increasing complexity of pharmacologic interventions led Levine to recognize the inadequacies of "the medication procedure" nurses are taught, which she described as "a ritual, complete with the powerful emotions which attend ritualistic behavior."109 Although the "five rights" (right drug, right dose, right route, right time, right patient) were well known, Levine noted that it was commonplace for the wrong drug to be administered in the wrong dose, by the wrong route, and at the wrong time to the wrong patient. The article called for comprehensive reform of medication delivery, using a team approach that involved a nurse, a physician, and a pharmacist and emphasized the availability of nurse-oriented resource materials. In the 1970s, medication safety was also addressed in articles focused on warfarin interactions,110 the transition to U-100 insulin,111 lidocaine toxicity,112 and the benefits of unit-dose medication systems.113

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1970-1979

An article on stroke discussed such interventions as bed rest, side rails, and restraints or presence of a family member to avoid use of restraints.114 Trought warned of potentially dangerous equipment used in patient care, provided examples of related hazards, and advised nurses to develop procedures for reporting defective or malfunctioning equipment.115


Intermittent positive pressure breathing treatments, at one time a standard part of care, became controversial in the 1970s as their potential to cause a pneumothorax was recognized. Nurses were advised to use safer methods to deliver aerosolized drugs, such as hand nebulizers, and to help patients mobilize secretions by using mucolytic aerosols and expectorants, providing sufficient hydration, and encouraging patients to practice coughing and deep breathing.116 Articles continued to remind nurses that urinary catheters could be sources of nosocomial infections117, 118 and that cuffed endotracheal tubes could cause tracheal necrosis.119 Several articles were devoted to safe administration of IV therapy and the dangers of stopcock contamination.120-122


Despite these strides, there were many missed opportunities to emphasize patient safety and nursing care. An article on perceptual defects in hemiplegia explained that such defects can be both puzzling to others and dangerous. The authors described nursing care and offered readers a number of strategies for providing patients an environment more conducive to success, stimulation, and safety in dressing and moving.123 Morris and Rhodes wrote about the care of confused patients.124 The article did not discuss how to protect disoriented, delusional, or psychotic patients from self-injury, but rather focused on how to differentiate functional from organic confusion-a distinction that can help nurses prevent some patients from becoming increasingly confused and others from being restrained unnecessarily or from receiving inappropriate medication. Reminiscent of articles from earlier in the century, a 1973 article about depression was authored by a physician and a psychologist. While it made no specific recommendations for keeping depressed patients safe, its purpose was to help nurses recognize the signs and symptoms of depression, so patients could receive proper care.125


1980-1989. In the 1980s, health care communities became increasingly aware of the need to focus on accident prevention. Discussing the results of a retrospective analysis of four-and-a-half years of nurse-initiated incident reports at a 629-bed teaching hospital, Lynn noted that accidents could be categorized either as falls or as "patient-inherent," procedure-related, or equipment-related incidents.126 In addition, accidents were found to occur most frequently between the hours of 8:30 am and 1 pm and during the summer months when staff turnover was highest. Diagnoses associated with the highest risk of accidents included neurologic disorders; chronic debilitating disorders, such as anemia, pulmonary or heart disease, or immunosuppressant disorder; and cancer, especially if metastatic or at an advanced stage. Physical, mental, and sensory status impairments were also found to increase the risk of accidents. Safety precautions, such as using nonskid footwear and bed brakes, and planning patient rounds to meet patient needs, were recommended.126 Focusing on the reduction of sensory deficits on safety, Bozian and Clark suggested reducing background noise, supplying reading material in large print, having door frames painted in vivid colors, keeping traffic patterns clear, and encouraging physical activity and balance exercises.127

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1980-1989

Medication safety also remained a priority in this decade. The unit-dose system was gradually implemented, initially to reduce nursing time, medication waste, and costs to patients, though it was soon found to reduce medication errors and transcription errors on medication tickets because it required physician orders to be double-checked by both nurses and pharmacists. A 1980 overview by Palmer identified some distribution problems built into its increasingly widespread use and the potential for mistakes resulting from nurse frustration with these problems and their subsequent workarounds, and called on nurses to communicate the difficulties in order to make the system workable and safe.128 In 1982, AJN introduced the column Nurses' Drug Alert in an editorial by Mary B. Mallison.129, 130 The column was intended to alert nurses "to important clinical developments in current drug usage."130


Medication errors were known to cause patient harm and nursing liability. System processes and similar packaging of drugs available in multiple dosages contributed to errors. In the column The Legal Side, Cushing addressed some of the legal hazards nurses may face in connection with such errors, advising nurses that they could reduce drug errors by avoiding rote administration, knowing appropriate dosages, identifying and reporting system problems, and including patients in medication administration procedures.131


Transcription processes were also identified as a source of medication errors. Cushing cautioned nurses that they may be held liable for failing to challenge an incorrect order; clarify an incomplete order; or review all order transcriptions for accuracy, consistency, and sequence.132


Cushing used legal issues to promote patient safety in other nursing practice areas as well. She warned that nurses were liable if they failed to communicate or act on critical information that resulted in patient harm and encouraged nurses to anticipate possible safety hazards based on patients' conditions.133


Equipment and procedural errors were frequent article topics. Ostrow and O'Rourke discussed how to prevent air embolism in central venous catheters and how to respond if an embolism occurs.134, 135 Brosnan and colleagues authored a continuing education article on reducing stopcock contamination and associated sepsis.136 McFadden described how to determine the need for suctioning, and thereby reduce respiratory compromise, in intubated neonates.137


In the early 1980s, a study commissioned by the U.S. Food and Drug Administration (FDA) found that accidental disconnections of breathing tubes from ventilators, which may be fatal if not quickly discovered and remedied, were common and rarely reported events.138 An AJN article by Janowski discussed the FDA's interim report, which recommended equipment and alarm modification, dissemination of the findings among nurses, and increased institutional data collection regarding the circumstances surrounding disconnections.138


Articles addressed the potential for serious injury associated with arterial access procedures, outlining measures for monitoring such procedures and intervening to preserve function and life if complications arose.139 Irwin and Openbrier discussed complications associated with nutritional support of patients receiving mechanical ventilation, advising nurses that they can often prevent aspiration pneumonia by passing nasoenteric feeding tubes beyond the pylorus, confirming tube placement by X-ray or fluoroscopy, avoiding excessive stomach filling, and keeping the patient's head elevated.140


Since safety data on the reuse of disposable devices were scarce, Radany and colleagues recommended against the reuse of critical invasive devices, suggesting that nurses convene an interdisciplinary committee to investigate complications associated with the practice and prepare guidelines.141 Other safety topics covered in this era included protecting vulnerable patients from shock when using electrical equipment142 and using bed alarms to reduce restraint use.143


1990-1999. The prevention of medication errors became the focus of a monthly AJN column, Med Errors, beginning in October 1993. The column covered numerous reasons such errors occur, including use of chemical names rather than generic names,144 interruptions during medication administration,145 failure to clarify questionable orders,146 the use of trailing zeros,147-149 look-alike and sound-alike medications,150, 151 failure to educate patients on their medications,152-154 and the admission of patients with the same name to the same room.155 The column also provided medication safety tips, such as confirming the "five rights" and reading labels three times,156 and explored technologic solutions to prevent errors, such as using electronic medication administration records,157 using systems theory to refine policies and procedures,158 and communicating equivalent doses when prescribing prodrug formulations.159

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 1990-1999

Various authors drew attention to the structural and process changes of the 1990s, which reduced the number of RNs at the bedside, increased patient and family complaints, worsened nurse-sensitive outcomes, and reduced perceived quality of care.160, 161 When delegation to unlicensed assistive personnel emerged as a factor in patient safety, Parkman emphasized the "four rights of delegation"-delegating the right task to the right person, using the right communication (clear and concise, specifying both the objective and the expectations), and providing the right feedback.162 Nurses were encouraged to know the skill levels of the personnel to whom they delegated tasks,163 to recognize the dangers associated with inappropriate delegation, and to prevent employers from making staffing changes that encouraged inappropriate delegation.164 The ANA developed nurse staffing principles that called for health care organizations to define unit intensity based on the number of patients within the unit levels of intensity, environmental architecture and geography, available technology, and competency of the care providers, and to gather data on the relationship between staffing and patient outcome.165 Articles encouraged institutions to improve patient safety and quality of care by investigating the causes of errors, rather than blaming individuals.166


In the late 1990s, reducing the use of patient restraints emerged as a nursing priority. In order to improve patient safety, the Joint Commission, then known as the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), required nurses to try alternatives before restraining patients,167 and revised the standards for restraint use in nonpsychiatric patients.168


2000-2015. In the 2000s, articles on patient safety began to focus less on human performance and more on such systemic factors as poor communication among health care workers, patient-nurse ratios, nurse skill mix, disruptive or inappropriate provider behavior, shift work, and long working hours.169-172 To address safety issues, articles proposed new health information technology, standards for interprofessional communication, use of standardized patient assessment tools and checklists, and simulation as an educational tool.169, 173-176 Throughout these 15 years, four columns with a patient safety focus appeared in various issues: Med Errors, Practice Errors, Health and Safety, and Safety Monitor.

Box. Summary of Find... - Click to enlarge in new window Summary of Findings: 2000-2015

In 2001, Talerico and Capezuti critically examined the use of side rails through the years and dispelled myths regarding their usefulness as safety devices.177 Illustrations depicted several ways patients may become entrapped by side rails and injured, even fatally. The authors included a decision tree to guide nurses in selecting alternative safety equipment.


In 2003, Clarke and Aiken suggested that the medical performance measure "failure to rescue" could be used to evaluate nursing care.170 The authors proposed that this measure, which refers to the failure to prevent patient deaths from complications, emphasizes the need for surveillance (assessing and recognizing complications) and timely action (anticipating complications and mobilizing a care team when they occur). The authors pointed out that lower nurse-patient ratios were consistently linked with high failure-to-rescue rates.


Durkin discussed establishing rapid response teams as a means of getting caregivers to the bedside quickly.178 Although hospitals had used "code blue" teams for many years, they were summoned only after patients experienced a cardiac or respiratory arrest. The goal of rapid response teams was to intervene before these devastating and often irreversible events occurred.


Analyses of medication errors continued to focus on systemic factors and to move away from placing blame on individuals. The executive summary of a symposium on safe medication administration identified barriers to medication safety in research, education, policy, practice, and administration.179 Changes in Medicare reimbursement for several preventable hospital-acquired conditions resulted in improved safety efforts for preventable "never" events.180 Roark described an FDA proposal that would require drug manufacturers to place bar codes on all prescription and over-the-counter medications used in hospitals-a method that had drastically reduced medication errors when instituted previously in Veterans Health Adminstration hospitals.174


Articles recommended medication reconciliation as a way to reduce medication errors that occur during transition periods (admission to the hospital, transfer to another unit, discharge to home)181, 182 and the use of care bundles (multiintervention protocols) to remedy problems commonly associated with specific physiologic conditions. AJN published articles on care bundles that addressed ventilator-associated pneumonia,183 sepsis,184 central line-associated bloodstream infections,185 and even socioeconomic barriers to treatment.186



Before the discovery of antibiotics, the only tools available to halt the spread of disease were asepsis, isolation, and cleanliness. As a result, attention to infectious diseases was a central focus of AJN articles in the journal's first decades. In the early 20th century, when nurses were not yet recognized as having an independent professional identity distinct from that of physicians, articles were often written by physicians and adhered to a medical model, emphasizing symptoms and diagnoses rather than nursing care. Perhaps as a result, medical procedures were often instituted with no apparent recognition of safety threats.


The increasing complexity of nursing procedures, equipment, and medication regimens; a growing sense of independent professional identity; and various pressures exerted by World War II emerged as driving forces in the development of safety protocols and the recognition of rapid intervention as key to patient survival. Today's nurses continue to recognize the importance of rapid intervention through the use of emergency protocols, rapid response teams, and guidelines that expedite lifesaving interventions. The Centers for Medicare and Medicaid Services supports the ability of nurses to enter orders into the computerized electronic health record in accordance with state, local, and professional guidelines to promote early treatment and reduce delays.187


A shortage of nurses at the bedside during and after World War II resulted in an increased use of unlicensed assistive personnel. Nurses came to recognize the dangers associated with inappropriate delegation, prompting the ANA to develop safe staffing principles and to call on health care organizations to use a wider range of metrics to define unit intensity levels. In 1999, legislation passed in California gave rise to the movement to implement minimum nurse-patient staffing ratios. Since that time, the debate on how to determine and ensure safe nurse staffing has become a national conversation, with bills introduced at the federal level.172 The resistance of health care facilities to follow safe staffing principles remains an issue for nurses today. In response, Senator Jeff Merkley (D-OR) and Representatives Lois Capps (D-CA) and David Joyce (R-OH) introduced into Congress the ANA-supported Registered Nurse Safe Staffing Act, which would require all hospitals participating in Medicare to establish RN staffing plans, using a committee composed primarily of direct care nurses.188, 189


Specialized nursing education and in-service programs were identified as fundamental to patient safety in the 1950s. The importance of ongoing nursing education continues today. In its 2010 report, The Future of Nursing: Leading Change, Advancing Health, the IOM has called for educational pathways that would enable licensed RNs who have a diploma or associate's degree to obtain a baccalaureate, and for residency programs for nurses who have completed prelicensure or advanced practice degree programs or are transitioning into a new clinical practice area.190 The IOM further called on schools of nursing to double the number of nurses with doctoral degrees by the year 2020.187 The IOM holds that "[a]ll health care organizations and schools of nursing should foster a culture of lifelong learning and provide resources for interprofessional continuing competency programs."190


Throughout the years, numerous authors recommended instituting safety measures, including better methods for identifying patients before intervention, increased accountability when administering such high-alert medications as insulin, and improved caregiver comunication, which were subsequently recommended in the JCAHO Patient Safety Goals 2003.191 In fact, the 1939 recommendation by nurses to hold meetings to discuss hospital safety and safety education39 may have been an early attempt to promote interprofessional collaboration, a current safety recommendation of the IOM.190


The goal of the 1999 IOM To Err Is Human report was to break the cycle of inaction with regard to patient safety. The report was successful in fostering the recognition that errors were often due to systemic factors rather than the actions of individuals. Articles published between 2000 and 2015 focused on the systemic factors that affect patient safety and proposed systemic solutions. History teaches us the importance of implementing recognized solutions in a timely manner. As key stakeholders with the power to advance proven safety measures, nurses must encourage the necessary changes through education and leadership.


Limitations. This content analysis was limited in that all articles were published in a single journal. Articles with important safety information would certainly have been published in other nursing journals as well, but AJN is the oldest continuously published nursing journal and, as such, provides a lens through which to view trends in patient care and safety. One strength of the analysis is that both the search for relevant articles and the article analyses were conducted independently by the two authors.



Our content analysis of articles published in AJN revealed that patient safety was a primary goal of nursing from the journal's inception in 1900. However, the recognition of safety threats and the response of nurses changed over time. Three major themes related to patient safety were repeated throughout the 115 years covered in this analysis: infection prevention, medication safety, and response to new technology. Over the past several decades, processes and procedures to improve patient safety have been recommended but have not been universally adopted, despite substantial supportive evidence. The IOM highlighted patient safety as a serious public health issue in 1999. Although efforts have been made to improve patient safety since that time, the work "has progressed at a rate much slower than anticipated."192 Reflecting on the historical and contemporary role of the nurse in promoting patient safety and overcoming barriers to the implementation of safety measures may inspire nurses to take action that improves patient safety today.




1. Kohn LT To err is human: building a safer health system. Washington, DC: National Academy Press; 2000. [Context Link]


2. 2004 JCAHO National Patient Safety Goals approved Jt Comm Perspect 2003 23 9 1, 3 [Context Link]


3. QSEN Institute QSEN project overview: the evolution of the Quality and Safety Education for Nurses (QSEN) initiative. Cleveland, OH: Frances Payne Bolton School of Nursing, Case Western Reserve University; 2014. [Context Link]


4. James JT A new, evidence-based estimate of patient harms associated with hospital care J Patient Saf 2013 9 3 122-8 [Context Link]


5. Smith RR The duties of the nurse in the management of major operations in private homes Am J Nurs 1908 8 11 880-90 [Context Link]


6. Gilmour MS What a nurse should be taught Am J Nurs 1908 9 1 8-11 [Context Link]


7. Dick SM Contagious nursing in private homes Am J Nurs 1906 6 8 511-3 [Context Link]


8. Gallegher FW The nurse, the doctor, and the public Am J Nurs 1905 5 5 305-9 [Context Link]


9. Huber JB Lobar pneumonia: its causes, symptoms, prevention, and treatment Am J Nurs 1913 14 3 168-81


10. Purcell M Nursing care of the insane Am J Nurs 1911 11 6 430-3


11. Smith MD Incubator babies Am J Nurs 1911 11 10 791-4


12. Hawley EA Manifestations of delirium in the night-time Am J Nurs 1908 8 10 757-61 [Context Link]


13. Jelliffe SE Emergency care of the mentally disordered, part II Am J Nurs 1912 12 6 479-84 [Context Link]


14. Mabon W, Townsend AR Hydrotherapy as practiced in the Manhattan State Hospital Am J Nurs 1910 10 4 239-43 [Context Link]


15. Barclay HV Medical gymnastics in locomotor ataxia: the Frenkel and other exercises Am J Nurs 1913 13 6 428-36 [Context Link]


16. Ehrlicher C The baking oven Am J Nurs 1909 10 2 106 [Context Link]


17. Smith FM Electrotherapy: a new and interesting field for nurses Am J Nurs 1921 21 5 299-301 [Context Link]


18. Duchesne ML A labor-saving device Am J Nurs 1923 23 6 470-2 [Context Link]


19. Domitilla M Improved method of applying hot surgical dressings Am J Nurs 1923 24 1 12-4 [Context Link]


20. Haehnlen A A simple method of procuring blood for diagnosis from infants Am J Nurs 1921 21 11 786-8 [Context Link]


21. Hubbard LD Nursing the mental patient Am J Nurs 1927 27 3 179-81 [Context Link]


22. High-alert medications and patient safety Sentinel Event Alert 1999 11 1-3 [Context Link]


23. Brown NG The treatment of diabetes with the aid of insulin Am J Nurs 1923 24 2 82-8 [Context Link]


24. A bed for helpless patients Am J Nurs 1924 24 4 276 [Context Link]


25. Friend HLP The Ward manual Am J Nurs 1924 24 14 1111-13 [Context Link]


26. Russell MM Hospital furnishings Am J Nurs 1926 26 11 841-6 [Context Link]


27. Mithoefer W, Culberson W Concerning tonsils: facts of interest to the nurse Am J Nurs 1928 28 3 199-205 [Context Link]


28. Johnson CA Living safely with electricity Am J Nurs 1929 29 6 659-67 [Context Link]


29. Continuous bath: as given at the Cook County hospital, Chicago Am J Nurs 1929 29 2 147-8 [Context Link]


30. Holbrow JM Some problems in nursing an aged patient Am J Nurs 1931 31 2 174-5 [Context Link]


31. Rosenfield HH, Yeo C Analgesia in obstetrics Am J Nurs 1935 35 5 437-42 [Context Link]


32. Lohman EL Pouring and passing medicines Am J Nurs 1933 33 1 29-31 [Context Link]


33. Faddis MO Eliminating errors in medication Am J Nurs 1939 39 11 1217-23 [Context Link]


34. Taylor AM The diabetic patient: dangers in inexact nursing Am J Nurs 1938 38 8 866-8 [Context Link]


35. Olson LM Oxygen therapy: history, administration, and nursing aspects Am J Nurs 1933 33 3 187-96 [Context Link]


36. Cutler M The radium treatment of cancer Am J Nurs 1934 34 7 641-8 [Context Link]


37. Engen G Nursing care in heart disease Am J Nurs 1931 31 4 406-10 [Context Link]


38. Best DR Sulphanilamide and nursing care Am J Nurs 1937 37 9 950-2 [Context Link]


39. Schoofs AB Safety in hospitals Am J Nurs 1939 39 3 274 [Context Link]


40. Rich BE An inhalation screen Am J Nurs 1940 40 1 20-1 [Context Link]


41. Graves GW Accident prevention in pediatric nursing Am J Nurs 1949 49 1 28-31 [Context Link]


42. Martin ML Accidents in a children's hospital: and a plan for their control Am J Nurs 1944 44 2 155-7 [Context Link]


43. Irene BW Foot supports in polio Am J Nurs 1947 47 5 323 [Context Link]


44. McQuaid AR Our new visible card file Am J Nurs 1949 49 12 794-5 [Context Link]


45. Hofmann HM, et al Sawdust bed therapy: for the prevention and treatment of pressure sores Am J Nurs 1949 49 10 654 [Context Link]


46. Setzler L A shock ward in the ETO: shock ward setup and nursing personnel Am J Nurs 1944 44 10 935-7 [Context Link]


47. Welch EM The shock cart Am J Nurs 1946 46 12 845 [Context Link]


48. Conboy CF A recovery room Am J Nurs 1947 47 10 685-7 [Context Link]


49. Carnahan JM Recovery room for postoperative patients Am J Nurs 1949 49 9 581-2 [Context Link]


50. Hurlburt M, Oscadal JM The obstetric recovery room Am J Nurs 1949 49 3 136 [Context Link]


51. Richardson MA We prepare for disaster at Bridgeport Hospital, Bridgeport, Connecticut Am J Nurs 1941 41 8 902-3 [Context Link]


52. Baehr G The Office of Civilian Defense and professional nursing standards Am J Nurs 1941 41 12 1419-20 [Context Link]


53. Waitt AH War gas cases: first aid treatment Am J Nurs 1942 42 5 489-98 [Context Link]


54. Barrett J Simplifying nursing procedures Am J Nurs 1943 43 8 713-6 [Context Link]


55. Criteria for the assignment of the nursing aide Am J Nurs 1949 49 5 311-4 [Context Link]


56. Jones E, Ellsworth JG An experiment in team assignment Am J Nurs 1949 49 3 146-8 [Context Link]


57. Knox CM Hospital licensure and its relation to nursing Am J Nurs 1949 49 12 755 [Context Link]


58. Pellenz D Fires in hospitals and nurses' homes Am J Nurs 1949 49 1 40-2 [Context Link]


59. Ruth W Fire control Am J Nurs 1946 46 10 666-7 [Context Link]


60. Livingstone HM Administration of oxygen therapy Am J Nurs 1948 48 2 88-91 [Context Link]


61. McCurdie MH Anesthesia explosion hazards: some methods of control Am J Nurs 1941 41 3 261-4 [Context Link]


62. Leon A Postanesthetic and postoperative recovery units Am J Nurs 1952 52 4 430-2 [Context Link]


63. Matthews TB The surgical recovery room Am J Nurs 1951 51 11 669 [Context Link]


64. McIntyre E Crash ward Am J Nurs 1952 52 2 183-4 [Context Link]


65. Abdellah FG, Strachan EJ Progressive patient care Am J Nurs 1959 59 5 649-55 [Context Link]


66. Losty MA, et al A transport service for premature babies Am J Nurs 1950 50 1 10-2 [Context Link]


67. Latham HC Safe care for hospitalized children Am J Nurs 1951 51 6 403-4 [Context Link]


68. Press E Accident prevention Am J Nurs 1950 50 3 174-6 [Context Link]


69. Carnevali D, Sheldon NS How early ambulation affects nursing service Am J Nurs 1952 52 8 954-6 [Context Link]


70. Fleming JS Safety for hospital patients Am J Nurs 1953 53 4 465-7 [Context Link]


71. Griffin NL Preventing fires and explosions in the operating room Am J Nurs 1953 53 7 809-12 [Context Link]


72. Ludlam JE Bedrails: up or down? Am J Nurs 1957 57 11 1439-40 [Context Link]


73. Parrish HM, et al Accidents to patients can be prevented Am J Nurs 1958 58 5 679-82 [Context Link]


74. Stapleton EW A radioisotope clinic Am J Nurs 1959 59 2 224-7 [Context Link]


75. Sponge counts Am J Nurs 1957 57 9 1169 [Context Link]


76. X-rays declared safe Am J Nurs 1958 58 9 1277 [Context Link]


77. Hall MW Patient-information plates Am J Nurs 1953 53 2 191-2 [Context Link]


78. McKeown A, et al If you ask me. How do you make sure that patients are properly identified? Am J Nurs 1957 57 12 1596 [Context Link]


79. Byrne AK Errors in giving medication Am J Nurs 1953 53 7 829-31 [Context Link]


80. The dangers of intravenous therapy Am J Nurs 1959 59 3 369 [Context Link]


81. Frohman IP The barbiturates Am J Nurs 1954 54 4 432-4 [Context Link]


82. Grimm EL Narcotics control in the hospital Am J Nurs 1954 54 7 862-3 [Context Link]


83. Millman M Can drugs reduce weight? Am J Nurs 1955 55 3 308-9 [Context Link]


84. Newberry WB Jr Sedatives have their place, but Am J Nurs 1957 57 10 1285-6 [Context Link]


85. Rath CE The prevention and management of blood transfusion hazards Am J Nurs 1955 55 3 323-6 [Context Link]


86. Shallowhorn G Intramuscular injections Am J Nurs 1954 54 4 438-41 [Context Link]


87. Matheney RV, Topalis M Nursing care for the acutely ill psychotic patient Am J Nurs 1950 50 1 27-9 [Context Link]


88. Peplau HE Themes in nursing situations Am J Nurs 1953 53 10 1221-23 [Context Link]


89. Peplau HE Themes in nursing situations Am J Nurs 1953 53 11 1343-5 [Context Link]


90. After a suicide attempt Am J Nurs 1955 55 3 345 [Context Link]


91. Delabarre HC An in-service program in neurologic nursing Am J Nurs 1951 51 8 498-500 [Context Link]


92. Germain LD Continuing in-service education Am J Nurs 1951 51 11 670-2 [Context Link]


93. Kaplan MH, Bernheim EJ Esophageal varices Am J Nurs 1964 64 104-7 [Context Link]


94. Fisk JE Nursing care of the patient with surgery of the biliary tract Am J Nurs 1960 60 1 53-5 [Context Link]


95. Peszczynski M Why old people fall Am J Nurs 1965 65 86-8 [Context Link]


96. Quimby MA Care of patients with labyrinthine dysfunction Am J Nurs 1960 60 12 1780-1 [Context Link]


97. Hershey N The law and the nurse. Negligence Am J Nurs 1962 62 98-9 [Context Link]


98. Hershey N A nurse's liability for negligence in supervision Am J Nurs 1962 62 115-6 [Context Link]


99. Gleason AM Cerebral edema. II. Care of the patient Am J Nurs 1961 61 3 93-4 [Context Link]


100. Reams GB, Powell EJ Postoperative catheterization-yes or no? Am J Nurs 1960 60 371 [Context Link]


101. Suddarth DS Individual dressing packs Am J Nurs 1960 60 7 991-2 [Context Link]


102. Hall JW III Drug therapy in infectious diseases Am J Nurs 1961 61 2 56-60 [Context Link]


103. Streeter S, et al Hospital infection-a necessary risk? Am J Nurs 1967 67 3 526-33 [Context Link]


104. American Nurses' Association platform 1960-1962 Am J Nurs 1960 60 8 1100 [Context Link]


105. Pons ER Jr Ambulatory use of oxygen Am J Nurs 1960 60 1775-6 [Context Link]


106. Canning MG Care of alcoholic patients Am J Nurs 1965 65 11 113-4 [Context Link]


107. Umscheid T With suicidal patients; caring for is caring about Am J Nurs 1967 67 6 1230-2 [Context Link]


108. Pigott R, Brickett F Visual neglect Am J Nurs 1966 66 1 101-5 [Context Link]


109. Levine ME Breaking through the medications mystique Am J Nurs 1970 70 4 799-803 [Context Link]


110. Koprowicz DC Drug interactions with coumarin derivatives Am J Nurs 1973 73 6 1042-4 [Context Link]


111. Lawrence PA U-100 insulin: let's make the transition trouble free Am J Nurs 1973 73 9 1539 [Context Link]


112. Mattea J, Mattea E Lidocaine and procainamide toxicity during treatment of ventricular arrhythmias Am J Nurs 1976 76 9 1429-31 [Context Link]


113. Stewart DY, et al Unit-dose medication: a nursing perspective Am J Nurs 1976 76 8 1308-10 [Context Link]


114. Jacobansky AM Stroke Am J Nurs 1972 72 7 1260-3 [Context Link]


115. Trought EA Equipment hazards Am J Nurs 1973 73 5 858-62 [Context Link]


116. Rau J, Rau M To breathe or be breathed: understanding IPPB Am J Nurs 1977 77 4 613-7 [Context Link]


117. Degroot J Indwelling catheters Am J Nurs 1975 75 3 448-9 [Context Link]


118. Langford TL Nursing problem: bacteriuria and the indwelling catheter Am J Nurs 1972 72 1 113-5 [Context Link]


119. White HA Tracheostomy: care with a cuffed tube Am J Nurs 1972 72 1 75-7 [Context Link]


120. Barlock AL, et al Nursing management of adriamycin extravasation Am J Nurs 1979 79 1 94-6 [Context Link]


121. McArthur BJ, et al Stopcock contamination in an ICU Am J Nurs 1975 75 1 96-7 [Context Link]


122. Snider MA Helpful hints on I.V.'s Am J Nurs 1974 74 11 1978-81 [Context Link]


123. Burt MM Perceptual deficits in hemiplegia Am J Nurs 1970 70 5 1026-9 [Context Link]


124. Morris M, Rhodes M Guidelines for the care of confused patients Am J Nurs 1972 72 9 1630-3 [Context Link]


125. Crary WG, Crary GC Depression Am J Nurs 1973 73 3 472-5 [Context Link]


126. Lynn FH Incidents-need they be accidents? Am J Nurs 1980 80 6 1098-101 [Context Link]


127. Bozian MW, Clark HM Counteracting sensory changes in the aging Am J Nurs 1980 80 3 473-6 [Context Link]


128. Palmer DA Unit dose Am J Nurs 1980 80 11 2062-3 [Context Link]


129. Nurses' drug alert Am J Nurs 1982 82 4 631-8 [Context Link]


130. Mallison MB Editorial: a matter of priorities Am J Nurs 1982 82 4 567 [Context Link]


131. Cushing M Drug errors can be bitter pills Am J Nurs 1986 86 8 895, 899 [Context Link]


132. Cushing M Who transcribed that order? Am J Nurs 1986 86 10 1107-8 [Context Link]


133. Cushing M First, anticipate the harm Am J Nurs 1985 85 2 137-8 [Context Link]


134. O'Rourke ME Reducing the risk of venous air embolism Am J Nurs 1988 88 6 886, 890 [Context Link]


135. Ostrow LS Air embolism and central venous lines Am J Nurs 1981 81 11 2036-8 [Context Link]


136. Brosnan KM, et al Stopcock contamination Am J Nurs 1988 88 3 320-4 [Context Link]


137. McFadden R Decreasing respiratory compromise during infant suctioning Am J Nurs 1981 81 12 2158-61 [Context Link]


138. Janowski MJ Accidental disconnections from breathing systems, what FDA found-and what you can do about it Am J Nurs 1984 84 2 241-4 [Context Link]


139. Fahey VA, Finkelmeier BA Iatrogenic arterial injuries Am J Nurs 1984 84 4 448-51 [Context Link]


140. Irwin MM, Openbrier DR Feeding ventilated patients-safely Am J Nurs 1985 85 5 544-6 [Context Link]


141. Radany MH, et al Is it safe to reuse disposables? Am J Nurs 1987 87 1 35-8 [Context Link]


142. Meth IM Electrical safety in the hospital Am J Nurs 1980 80 7 1344-8 [Context Link]


143. Morton D Five years of fewer falls Am J Nurs 1989 89 2 204-5 [Context Link]


144. Davis NM Watch out for misleading chemical names Am J Nurs 1993 93 10 14 [Context Link]


145. Davis NM Concentrating on interruptions Am J Nurs 1994 94 3 14 [Context Link]


146. Davis NM Clarifying questionable orders Am J Nurs 1994 94 4 16 [Context Link]


147. Davis NM Beware of trailing zeros Am J Nurs 1994 94 6 17 [Context Link]


148. Davis NM Confusion over illegible orders Am J Nurs 1994 94 1 9 [Context Link]


149. Davis NM Decimal point dangers Am J Nurs 1994 94 1 9 [Context Link]


150. Lilley LL, Guanci R Sound-alike cephalosporins. How drugs with similar spellings and sounds can lead to serious errors Am J Nurs 1995 95 6 14 [Context Link]


151. Lilley LL, Guanci R When 'look-alikes' and 'sound-alikes' don't act alike Am J Nurs 1997 97 9 12-4 [Context Link]


152. Davis NM A well-informed patient is a valuable asset Am J Nurs 1994 94 2 16 [Context Link]


153. Davis NM More patient education tips Am J Nurs 1994 94 2 16 [Context Link]


154. Davis NM Teaching patients to prevent errors Am J Nurs 1994 94 5 17 [Context Link]


155. Ahmed DS, Hamrah PM Similar name, different diagnosis. When two patients shouldn't be in the same room Am J Nurs 1999 99 5 12 [Context Link]


156. Lilley LL, Guanci R Getting back to basics Am J Nurs 1994 94 9 15-6 [Context Link]


157. Davis NM Can computers stop errors? Am J Nurs 1994 94 12 14 [Context Link]


158. Lilley LL, Guanci R Applying systems theory Am J Nurs 1995 95 11 14-5 [Context Link]


159. Lilley LL, Guanci R Equivalence dosing Am J Nurs 1997 97 3 12 [Context Link]


160. Malone B, et al Survey reactions: a grim prognosis for health care? Am J Nurs 1996 96 11 40-4 [Context Link]


161. Shindul-Rothschild J, et al 10 keys to quality care Am J Nurs 1997 97 11 35-43 [Context Link]


162. Parkman CA Delegation: are you doing it right? Am J Nurs 1996 96 9 42-7 [Context Link]


163. Boucher MA Delegation alert! Am J Nurs 1998 98 2 26-32 [Context Link]


164. Canavan K Combating dangerous delegation Am J Nurs 1997 97 5 57-8 [Context Link]


165. Gallagher RM, et al ANA's nurse staffing principles Am J Nurs 1999 99 4 50-3 [Context Link]


166. Grant SM Who's to blame for tragic error? Am J Nurs 1999 99 9 9 [Context Link]


167. Brenner ZR, Duffy-Durnin K Toward restraint-free care Am J Nurs 1998 98 12 16F-16I [Context Link]


168. Rogers PD, Bocchino NL Restraint-free care: is it possible? Am J Nurs 1999 99 10 26-33 [Context Link]


169. Burke M, et al Communicating for better care: improving nurse-physician communication Am J Nurs 2004 104 12 40-7 [Context Link]


170. Clarke SP, Aiken LH Failure to rescue Am J Nurs 2003 103 1 42-7 [Context Link]


171. Rosenstein AH, O'Daniel M Disruptive behavior and clinical outcomes: perceptions of nurses and physicians Am J Nurs 2005 105 1 54-64 [Context Link]


172. Wallis L Nurse-patient staffing ratios Am J Nurs 2013 113 8 21-2 [Context Link]


173. Hohenhaus S, et al Enhancing patient safety during hand-offs: standardized communication and teamwork using the 'SBAR' method Am J Nurs 2006 106 8 72A-72B [Context Link]


174. Roark DC Bar codes and drug administration Am J Nurs 2004 104 1 63-6 [Context Link]


175. Shanks LC, Enlow MZ Medication calculation competency Am J Nurs 2011 111 10 67-9 [Context Link]


176. Stevens JD, et al Cultivating quality: implementing standardized reporting and safety checklists Am J Nurs 2011 111 5 48-53 [Context Link]


177. Talerico KA, Capezuti E Myths and facts about side rails Am J Nurs 2001 101 7 43-8 [Context Link]


178. Durkin SE Implementing a rapid response team Am J Nurs 2006 106 10 50-3 [Context Link]


179. Burke KG Executive summary: the State of the Science on Safe Medication Administration symposium Am J Nurs 2005 105 3 73-9 [Context Link]


180. Kurtzman ET, Buerhaus PI New Medicare payment rules: danger or opportunity for nursing? Am J Nurs 2008 108 6 30-5 [Context Link]


181. Barnsteiner JH Medication reconciliation: transfer of medication information across settings-keeping it free from error Am J Nurs 2005 105 3 Suppl 31-6 [Context Link]


182. Ketchum K, et al Medication reconciliation: verifying medication orders and clarifying discrepancies should be standard practice Am J Nurs 2005 105 11 78-85 [Context Link]


183. Kunis KA, Puntillo KA Ventilator-associated pneumonia in the ICU: its pathophysiology, risk factors, and prevention Am J Nurs 2003 103 8 64AA-64GG [Context Link]


184. Nelson DP, et al Recognizing sepsis in the adult patient Am J Nurs 2009 109 3 40-5 [Context Link]


185. Reed SM, et al Champions for central line care Am J Nurs 2014 114 9 40-8 [Context Link]


186. Bracken J Bundle up Am J Nurs 2009 109 3 11 [Context Link]


187. Emergency Nurses Association. Use of protocols in the emergency setting. Des Plaines, IL; 2015 Jul. Position statement;[Context Link]


188. American Nurses Association. ANA commends introduction of the Registered Nurse Safe Staffing Act [press release]. 2015 Apr 29. [Context Link]


189. American Nurses Association. Safe staffing. 2016. [Context Link]


190. Altman SH, et al Assessing progress on the Institute of Medicine report the future of nursing. Washington, DC: National Academies of Sciences, Engineering, Medicine 2016. [Context Link]


191. VA National Center for Patient Safety. Special edition: JCAHO patient safety goals 2003 TIPS: topics in patient safety 2002 2 5 1-10 [Context Link]


192. National Patient Safety Foundation. Free from harm: accelerating patient safety improvement fifteen years after To Err is Human. Boston; 2015.[Context Link]


For 117 additional continuing nursing education activities on safety, go to