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blue light, fungal infection, growth inhibition,



  1. Guffey, J. Stephen EdD, PT
  2. Payne, William MS, MT(ASCP)
  3. Buchanan, Ben DPT
  4. Daugherty, Jessie DPT
  5. Meurer
  6. , Logan
  7. Hensley, Patricia BS


OBJECTIVE: To determine whether a blue light (405 nm) could inhibit the growth of Trichophyton mentagrophytes without using a photosensitizing material as part of the treatment protocol.


DESIGN: Basic physiologic randomized trial using laboratory specimens (T mentagrophytes).


INTERVENTIONS/METHODS: Plated on a growth medium, T mentagrophytes were exposed to 3 to 5 administrations of blue light at 20 J/cm2 over 28 hours. Following 7 days of incubation, colony-forming units were counted and compared with nonirradiated controls.


RESULTS: The study found 3, 4, and 5 administrations of blue light produced significant inhibition of T mentagrophytes (P < .05); 4 and 5 applications produced the greatest inhibition of growth (84.7% and 93.6% kill rates, respectively).


CONCLUSIONS: The application of 405-nm light at a dose of 20 J/cm2 is an effective in vitro inhibitor of T mentagrophytes. To give results similar to those seen when a photosensitizing material is included, 3 to 5 applications of this wavelength and dose condition delivered over 28 hours is likely needed.