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acellular flowable matrix, biomaterial, cavity ulcers, diabetic foot ulcers, flowable matrix, tunnel lesions



  1. Campitiello, Ferdinando MD
  2. Mancone, Manfredi PhD, MD
  3. Della Corte, Angela PhD, MD
  4. Guerniero, Raffaella MD
  5. Canonico, Silvestro MD


OBJECTIVE: The authors aimed to explore the feasibility and safety of an advanced, acellular, flowable wound matrix (FWM) in patients with diabetes-related cavity or tunnel lesions involving deep structures.


METHODS: Patients with diabetic foot ulcers were hospitalized at the General and Geriatric Surgery Unit of the University of Campania in Naples, Italy, between March 2015 and December 2015. Twenty-three patients with tunneled or cavity ulcers were treated. The lesions were filled with the FWM. Surgical wound edges were either approximated with stitches or left to heal by secondary intention.


MAIN RESULTS: After 6 weeks, 78.26% of patients completely healed after a single application of the FWM. The healing time for all healed wounds was 30.85 +/- 12.62 days, or 26.11 +/- 5.43 days in patients for whom wound edges were approximated by stitches, and 57.66 +/- 3.05 days in the patients who healed by secondary intention (P = .01). Permanent tissue regeneration was observed in a high percentage of patients, and shorter healing time was achieved. Study authors observed a low rate of complications such as major amputation and increased hospitalization.


CONCLUSIONS: The FWM seems ideal for tunneled and cavity ulcers with irregular geometry. This new porous matrix allows closure of the lesion while reducing healing time and demolition surgery.