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Scientists have discovered that it is possible to identify people at high risk of developing acute myeloid leukemia (AML) years before diagnosis. The researchers from Wellcome Sanger Institute, European Bioinformatics Institute, and their international collaborators found that patients with AML had genetic changes in their blood years before they suddenly developed the disease.

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The study found that blood tests looking for changes in the DNA code can reveal the roots of AML in healthy people (Nature 2018; doi:10.1038/s41586-018-0317-6). Further research could allow earlier detection and monitoring of people at risk of AML in the future, and open the prospect of developing ways to reduce the likelihood of developing this cancer.


Study Details

Mainstream treatments for AML treatments have changed very little for several decades and, while some patients are cured, the majority are not. To uncover the earliest steps in the development of AML, the researchers collaborated with the European Prospective Investigation into Cancer and Nutrition (EPIC) study.


Enrollment into EPIC started in 1992 and a large number of people have been enrolled and followed up for cancer development, with lifestyle data and blood samples collected. Some of these people later developed AML and, using their stored blood samples, the researchers were able to look back in time to see which genetic changes were already present years before the disease appeared.


The scientists, including researchers from the Princess Margaret Cancer Centre in Canada and the Weizmann Institute in Israel, sequenced the stored blood DNA from 124 AML patients and compared it to that from 676 people who remained free from AML or a related cancer.


Remarkably, they discovered that many of the people who went on to develop AML had particular genetic changes that set them apart from those who did not. These changes could be used collectively to develop a predictive test for AML risk.


"Acute myeloid leukemia often appears very suddenly in patients, so we were surprised to discover that its origins are generally detectable more than 5 years before the disease develops," noted Grace Collord, MD, joint first author on the paper from the Wellcome Sanger Institute and University of Cambridge. "This provides proof-of-principle that it may be possible to develop tests to identify people at a high risk of developing AML."


The study focused on selected genes known to be associated with AML and found frequent mutations in some of these genes in many individuals, including some people who did not develop AML. However, the researchers discovered that people who were en route to developing AML had a higher number of mutations and the mutations were often present in a larger fraction of their blood cells. Furthermore, specific blood test results were subtly different in those who later developed AML.


"We needed a large number of samples to get accurate results, and this study was only possible through a collaboration with EPIC," said Moritz Gerstung, PhD, one of the senior authors on the paper from the EBI. "The generosity of the participants in sharing their data and blood samples allowed us to discover a pattern of genetic changes that is established long before AML appears, and which confers greater risk when more cells are affected by genetic change. This genetic lag may also be found in other blood cancers, and this would open new avenues for further research that could help many people in the future."


Ongoing Research

Approximately five in 100,000 people in the general population develop AML each year. This means that any predictive tests need to be highly accurate in order to minimize the risk of false-positive results.


Despite the powerful methods used in the study, further research will be needed to enhance the accuracy of predictive tests to make them robust enough to use clinically. The aim is to identify individuals at risk of AML and monitor them closely, while developing approaches for preventing leukemia development.


"Our study provides for the first time evidence that we can identify people at risk of developing AML many years before they actually develop this life-threatening disease," concluded George Vassiliou, PhD, one of the joint leaders of the project from the Wellcome Sanger Institute and the Wellcome-MRC Cambridge Stem Cell Institute, and Consultant Hematologist at Cambridge University Hospitals NHS Foundation Trust.


"We hope to build on these findings to develop robust screening tests for identifying those at risk and drive research into how to prevent or stall progression towards AML. Our aspiration is that one day AML prevention would provide a compelling alternative to treatment."


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